A method of sterilizing a prefilled syringe comprises assembling a syringe assembly and performing at least one ethylene oxide (EtO) sterilization procedure cycle. The assembling step includes inserting a tip cap at a first end of a plunger, filling a non-glass barrel with sterilization sensitive material at a second end of the barrel, and inserting the plunger into the barrel at a second end to seal the sterilization sensitive material within the barrel. The EtO sterilization procedure cycle comprises undergoing a preprocessing stage, a wash and conditioning stage, an EtO sterilization stage and a wash and post exposure stage. Upon completing the EtO sterilization procedure cycle, a resultant pH of the sterilization-sensitive material does not exceed an acceptable pH range as defined by the United States Pharmacopeia. The disclosure also discusses inserting an assembled prefilled syringe into a procedure tray prior to performing the EtO sterilization procedure cycle.

Systems and methods for filling and sealing a container can include a housing having an opening for receiving containers, a rotary assembly including mount assemblies disposed in the housing, the rotary assembly operable to rotate the of mount assemblies about a central axis, a washing station, a filling station, a steam injector, and cap setter disposed in the housing.

Described and illustrated is a method to sterilise containers or receiving flowable foods; in a filling device. The method includes evaporating a hydrogen peroxide solution in an evaporator impinging at least one container with the vaporous hydrogen peroxide in a sterilisation zone and at least partially removing the unconsumed part of the vaporous hydrogen peroxide from the sterilisation zone. The removed vaporous hydrogen peroxide is at least partially condensed in a condenser and the condensed hydrogen peroxide is supplied to the evaporator.

Described and illustrated is a method to sterilise containers or receiving flowable foods; in a filling device. The method includes evaporating a hydrogen peroxide solution in an evaporator impinging at least one container with the vaporous hydrogen peroxide in a sterilisation zone and at least partially removing the unconsumed part of the vaporous hydrogen peroxide from the sterilisation zone. The removed vaporous hydrogen peroxide is at least partially condensed in a condenser and the condensed hydrogen peroxide is supplied to the evaporator.

A method for treating open cut edges of a packaging sleeve, blank or web material of a packaging material rolled up into a roll, in particular a composite cardboard/plastics material, by applying or introducing a disinfectant-containing treatment agent to or into the outer region of the cut edges. To provide a particularly resource-efficient composite packaging and a production method required for this purpose, it is proposed that at least some of the treatment agent is not applied directly to the cut edges, but that a load carrier is loaded, which load carrier absorbs the treatment agent so that an actively sterilising atmosphere which is created then acts on the open cut edges of the packaging sleeve, blank or web material and performs the desired sterilisation. The invention also relates to a packaging material, to a combipack produced therefrom and to a container for receiving the packaging material.

A method for treating open cut edges of a packaging sleeve, blank or web material of a packaging material rolled up into a roll, in particular a composite cardboard/plastics material, by applying or introducing a disinfectant-containing treatment agent to or into the outer region of the cut edges. To provide a particularly resource-efficient composite packaging and a production method required for this purpose, it is proposed that at least some of the treatment agent is not applied directly to the cut edges, but that a load carrier is loaded, which load carrier absorbs the treatment agent so that an actively sterilising atmosphere which is created then acts on the open cut edges of the packaging sleeve, blank or web material and performs the desired sterilisation. The invention also relates to a packaging material, to a combipack produced therefrom and to a container for receiving the packaging material.

A method is described of filling and/or sealing a packaging container. The packaging container can include a packaging laminate and having a top portion and a lower portion including one or more side walls and an open base. The method can include: supporting the packaging container with the open base uppermost on a support with an upstanding portion, wherein the support engages the top portion of the packaging container and engages part of the one or more side walls via the upstanding portion of the support; and filling the packaging container via its open base and/or sealing the open base of the packaging container, wherein the support ensures dimensional stability of the packaging container during the filling and/or sealing step. A related apparatus, support and packaging container are also described.

A hydrogen peroxide sterilization device for sterilizing a medical device, the hydrogen peroxide sterilization device including a hermetic outer container, a hydrogen peroxide pouch, and a hydrogen peroxide solution in the solution chamber. The hermetic outer container includes a sterilization enclosure configured to receive the medical device. The hydrogen peroxide pouch includes a permeable membrane enclosing a solution chamber and is configured to be positioned in the sterilization enclosure of the outer container. The permeable membrane is configured to allow hydrogen peroxide vapor to diffuse from the solution chamber through the permeable membrane into the sterilization enclosure.

A peracetic acid type sterilizing composition solution containing peracetic acid, acetic acid, hydrogen peroxide and catalase enzyme, wherein said sterilizing solution has a pH in a range of 2.6 to 5.0, said catalase enzyme is contained in an amount of 0.1 to 10 μg/ml, the concentration of said peracetic acid is 500 to 10,000 ppm, and the concentration of said hydrogen peroxide is less than 500 ppm. The concentration of the hydrogen peroxide can be efficiently decreased due to the catalase enzyme that is added in small amounts thereby suppressing the bubbling caused by the addition of the catalase enzyme.

An aseptic filling machine and an aseptic filling method are provided with which a petaloid-shape bottle or an unstable bottle is filled with sterilized content and sealed with a sterilized cap in an aseptic atmosphere is discharged without a delay from an aseptic zone to a non-aseptic zone and even if the petaloid-shape bottle or the unstable bottle falls over on a discharging conveyor when being discharged from the aseptic zone to the non-aseptic zone, a stopping time of the aseptic filling machine is shortened by providing a barrier chamber into which air containing a gas of a sterilizer is supplied and a discharge portion chamber that shields discharge portions that are provided downstream of the sealing portion that fills the content into the bottle and seals the bottle with the cap.