A tamper-resistant jar and lid including a jar having a tab removably coupled to the jar by at least one frangible connection. A first securement mechanism is disposed on the tab. A second securement mechanism is disposed on the lid. The second securement mechanism engages the first securement mechanism when the lid encloses the jar. The lid is inhibited from removal from the jar when the second securement mechanism engages the first securement mechanism until fracturing of the tab. The tab may include features to inhibit separation of the first and second securement mechanisms without destructively separating at least a portion of the tab from a flange of the jar, and the jar may include a pocket to receive a tab partially separated from the flange of the jar.