Unlike other sealing devices which are internal to a bag and adhered to the bag by heat or glue the current invention is external to the bag, is not adhered to the bag by heat or glue, is free to be moved up or down the bag to remove excess air, is reusable, and can be used on one type of a bag in one instant, removed, and be used on another type of bag. Furthermore, on current sealing devices if anything comes in-between the male and female seals which go directly into each other it renders the seal ineffective, but the current invention is not disturbed at all, and in fact the bag type container becomes part of the seal.

Unlike other sealing devices which are internal to a bag and adhered to the bag by heat or glue the current invention is external to the bag, is not adhered to the bag by heat or glue, is free to be moved up or down the bag to remove excess air, is reusable, and can be used on one type of a bag in one instant, removed, and be used on another type of bag. Furthermore, on current sealing devices if anything comes in-between the male and female seals which go directly into each other it renders the seal ineffective, but the current invention is not disturbed at all, and in fact the bag type container becomes part of the seal.

Unlike other sealing devices which are internal to a bag and adhered to the bag by heat or glue the current invention is external to the bag, is not adhered to the bag by heat or glue, is free to be moved up or down the bag to remove excess air, is reusable, and can be used on one type of a bag in one instant, removed, and be used on another type of bag. Furthermore, on current sealing devices if anything comes in-between the male and female seals which go directly into each other it renders the seal ineffective, but the current invention is not disturbed at all, and in fact the bag type container becomes part of the seal.

A tamper-evident package utilizes a transparent resealable adhesive structure such as a tape or a label to cover the closure opening. Upon a first opening of the package frangible portions of the package front between adjacent disconnected arcuate cuts are torn. This results in a package which is visually tamper-evident after a first opening. A series of disconnected arcuate cuts comprising an apex and two free ends are arranged in laterally extending opposing top and bottom rows. In one case the cuts have portions of their distal free ends which overlap vertically and are parallel and aligned with the longitudinal axis of the package. The cuts are preferably centered laterally and are flanked on the right and left sides by two continuous wavy slits. One row of the cuts can comprise cup shaped cuts with a flat linear portion of each cut lying along its apex.

A tamper-evident package utilizes a transparent resealable adhesive structure such as a tape or a label to cover the closure opening. Upon a first opening of the package frangible portions of the package front between adjacent disconnected arcuate cuts are torn. This results in a package which is visually tamper-evident after a first opening. A series of disconnected arcuate cuts comprising an apex and two free ends are arranged in laterally extending opposing top and bottom rows. In one case the cuts have portions of their distal free ends which overlap vertically and are parallel and aligned with the longitudinal axis of the package. The cuts are preferably centered laterally and are flanked on the right and left sides by two continuous wavy slits. One row of the cuts can comprise cup shaped cuts with a flat linear portion of each cut lying along its apex.

The multi-chambered well dosage form and device disclosed herein can be single or multi dose capable for administration of pharmaceuticals of a range of particle sizes. The present dosage devices and systems provide for improved efficiency and patient ease of use owing to its compact size and simple design, low cost, and consistent, contamination free dosing of dry powder medicaments or other agents. The present disclosure provides a multi-chambered dosage form containing dry powder medical composition containing chamber well with an internal piercing device and one or more adjacent gas-filled chamber wells to aid the dispense of the powder contents to the user and in certain embodiments, without the requirement of an external energy sources common with active devices known in the art. Said methods, systems and devices provide increased ejection fraction and hence greater efficiency of drug delivery above that as provided by current devices.

A package material may include one or more layers of plastic laminate, a first side, a second side and a penetration area. A weakening line may extend from the penetration area and may provide an opening area in the package material. The package material may include a plastic opening device, with a first and second portion attached to the first and second side, respectively, and a material bridge penetrating through the penetration area. The second portion may cover at least partly the penetration area and may include a guiding portion extending from the penetration area adjacent to the at least one weakening line as to facilitate rupturing substantially along the at least one weakening line.

A package material may include one or more layers of plastic laminate, a first side, a second side and a penetration area. A weakening line may extend from the penetration area and may provide an opening area in the package material. The package material may include a plastic opening device, with a first and second portion attached to the first and second side, respectively, and a material bridge penetrating through the penetration area. The second portion may cover at least partly the penetration area and may include a guiding portion extending from the penetration area adjacent to the at least one weakening line as to facilitate rupturing substantially along the at least one weakening line.

Package material comprises one or more layers of plastic laminate, a first side, a second side and a penetration area (40). A weakening line (30) extends from the penetration area (40) and provides an opening area (12) in the package material. The package material comprises a plastic opening device (2), with a first and second portion (4) attached to the first and second side, respectively and a material bridge (45) penetrating through the penetration area (40). The second portion covers at least partly the penetration area and comprises a guiding portion (35, 36) extending from the penetration area (40) adjacent to the at least one weakening line (30) as to facilitate rupturing substantially along the at least one weakening line.

Package material comprises one or more layers of plastic laminate, a first side, a second side and a penetration area (40). A weakening line (30) extends from the penetration area (40) and provides an opening area (12) in the package material. The package material comprises a plastic opening device (2), with a first and second portion (4) attached to the first and second side, respectively and a material bridge (45) penetrating through the penetration area (40). The second portion covers at least partly the penetration area and comprises a guiding portion (35, 36) extending from the penetration area (40) adjacent to the at least one weakening line (30) as to facilitate rupturing substantially along the at least one weakening line.