The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.

The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.

Method and systems for measuring growth rate in plant or aquatic animal species such as embryonic or adult fish. The methods and systems utilize the measurement of NADH.sub.2 production by detecting a colorimetric and fluorescent shift when a redox indicator such as resazurin is added to a sample. The colorimetric/fluorescent shift is indicative of the reduction of the redox indicator by NADH.sub.2. The methods and systems of the present invention may be used to predict growth potential of a plant or animal, and measuring the growth rate of said plant or animal may be helpful for identifying and selecting individuals within a group that have greater growth potential. The methods and systems of the present invention may help eliminate the need for special equipment (e.g., for measuring oxygen consumption), decrease variability of measures, and minimize the effects of external factors (feeding/hormonal status).

Fish embryos may be successfully vaccinated or therapeutically treated if the therapeutic agent is injected into the yolk sac. Therapeutic agents may be directly injected or released from microspheres and enter the circulation and tissues. Injection into the yolk sac, combined with the use of carriers, allows for a continued, controlled release of therapeutic agents and processing of antigens. Fish vaccination or therapeutic treatment, selecting fish embryos post fertilization at the one-cell to eyed egg stage of develpment, and injecting the yolk sac with carriers associated with an antigen(s) or therapeutic agent(s), may be fully automated.

Fish embryos may be successfully vaccinated or therapeutically treated if the therapeutic agent is injected into the yolk sac. Therapeutic agents may be directly injected or released from microspheres and enter the circulation and tissues. Injection into the yolk sac, combined with the use of carriers, allows for a continued, controlled release of therapeutic agents and processing of antigens. Fish vaccination or therapeutic treatment, selecting fish embryos post fertilization at the one-cell to eyed egg stage of develpment, and injecting the yolk sac with carriers associated with an antigen(s) or therapeutic agent(s), may be fully automated.

A nonhuman animal cancer model is described. The animal model includes an animal of the genus Peromyscus and xenograft cancer cells implanted in the animal. Methods for utilizing the animal model can include evaluation of growth and development of cancer cells as well as evaluation of known and potential cancer treatment therapies. The animal model can be utilized to examine the efficacy of an anticancer therapy at the preclinical stage, can be utilized to screen potential cancer treatments in an individualized cancer treatment protocol, and can be utilized for identification of biomarkers associated with particular cancers and/or particular anticancer therapies, among other beneficial uses.

A nonhuman animal cancer model is described. The animal model includes an animal of the genus Peromyscus and xenograft cancer cells implanted in the animal. Methods for utilizing the animal model can include evaluation of growth and development of cancer cells as well as evaluation of known and potential cancer treatment therapies. The animal model can be utilized to examine the efficacy of an anticancer therapy at the preclinical stage, can be utilized to screen potential cancer treatments in an individualized cancer treatment protocol, and can be utilized for identification of biomarkers associated with particular cancers and/or particular anticancer therapies, among other beneficial uses.

Provided are an antibody for sexing sperms and use thereof, and more particularly, a composition for and a method of sexing sperms by using the antibody, and a method of producing an animal of a particular sex. In the present disclosure, it was confirmed that agglutination of Y chromosome sperms may be induced by treatment of the antibody, thereby easily sorting X chromosome sperms and Y chromosome sperms. Therefore, it is possible to produce a large number of customized animals of a particular sex and to selectively produce livestock of a desired sex, and therefore, it is expected to contribute to planed breeding, breeding improvement, and efficient management.

The invention relates to a method for producing chicken at a hatchery, the method comprising; incubating a batch of eggs in an incubating device during an incubating period of between about 7 to about 20 days, and then, for each egg of the batch, detecting the presence of a hatchable chicken embryo, based on the presence of a hatchable chicken embryo, dividing the batch of eggs into at least a hatchable batch portions and a not-hatchable batch portion, hatching the hatchable batch portion until hatching occurs, rearing of chicken hatched from said hatchable batch portion,
wherein the method comprises at the hatchery processing the not-hatchable batch portion into feed and administering said feed at the hatchery to hatched chickens during rearing.

The invention relates to a method for producing chicken at a hatchery, the method comprising; incubating a batch of eggs in an incubating device during an incubating period of between about 7 to about 20 days, and then, for each egg of the batch, detecting the presence of a hatchable chicken embryo, based on the presence of a hatchable chicken embryo, dividing the batch of eggs into at least a hatchable batch portions and a not-hatchable batch portion, hatching the hatchable batch portion until hatching occurs, rearing of chicken hatched from said hatchable batch portion,
wherein the method comprises at the hatchery processing the not-hatchable batch portion into feed and administering said feed at the hatchery to hatched chickens during rearing.