A configurable cryogenic storage device has a freezer and a rack carrier positioned inside of the freezer. The freezer includes a bearing and a drive shaft though the freezer, the drive shaft being coupled to the rack carrier inside the freezer and adapted to be coupled to a motor assembly. The rack carrier rests on the bearing in a manual rotation configuration and hangs from the drive shaft when the motor is connected. Coupling the drive shaft to the motor assembly lifts the rack carrier and decouples the bearing and enables automated rotation of the rack carrier by the motor. The rack carrier includes rack-mounting features holding a plurality of sample storage racks. The sample storage racks hang from the rack carrier and the rack-mounting features precisely position the end of each sample storage rack.

The invention relates to a device for monitoring the temperature of a cryopreserved biological sample, comprising a sample container (1) having a receiving space (2) for receiving a biological sample (6) and a cover (3) for closing the receiving space. The device also comprises a chamber arranged inside the sample container, in particular in the receiving space and/or in the cover, the interior (12; 22; 32; 42) of which is not fluidically connected to the receiving space (2) and is only partially filled with at least one indicator substance (7) having a melting temperature in the region between 20 C. and 140 C. The invention also relates to a method for monitoring the temperature of cryopreserved samples, comprising the following steps: providing a device (10; 20; 30; 40) for 12b temperature monitoring; freezing the indicator sub stance/s, wherein the at least one chamber can be placed in a first position during the freezing of the indicator substance/s and in a second position after the freezing and when a temperature of the indicator substance/s is below the melting temperature, in which position a melting of the indicator substance/s leads to an at least partial shift and/or change in shape of the chamber filling, with the influence of the force of gravity.

The invention relates to a method for monitoring the temperature of a cryopreserved biological sample. The invention also relates to a device for monitoring the temperature of a cryopreserved biological sample. The device (10) for monitoring the temperature of a cryopreserved biological sample comprises a sample container (1) having a receiving space (2) for receiving a biological sample (6). The device also comprises at least one chamber (11) having an interior that is not fluidically connected to the receiving space (2) and is only partially filled with an indicator substance (7) with a melting temperature in a region of 20 C. to 140 C. The chamber (11) has a barrier (13) that causes the indicator substance (7) to move into a second sub-region (12b) of the chamber (11) when the indicator substance (7) in a first sub-region (12a) of the chamber is in the fluid aggregate state.

The invention relates to a device for monitoring the temperature of a cryogenically preserved biological sample. The device (10) comprises a sample container (1) having a receptacle space (2) for accommodating a biological sample (6). The device further comprises at least one chamber (11), the interior (12) of which is not fluidically connected to the receptacle space, and which is at least partially filled with an indicator substance (7) having a boiling point or sublimation temperature in a range from 10 C. to 140 C. The chamber (11) further has at least one opening via which the indicator substance (7) can escape from the interior (12) of the chamber (11) upon exceeding its boiling point or sublimation point. The invention further relates to a method for monitoring the temperature of a cryogenically preserved biological sample.

The present invention relates to a recovery assembly for a cooling agent in a cryopreservation device, the recovery assembly comprises a cone-shaped funnel assembly comprising a support for mounting the funnel assembly to an access opening of a container to be at least partially filled with a cooling agent.

The disclose provides a cell freezing kit having a device equipped with a filter, and a container having hermetic closing means, which is capable of containing the device equipped with a filter, and methods of use thereof.

The invention relates to a device for the temperature monitoring of a cryopreserved biological sample, comprising a sample container (in particular a cryotube) having a holding space for holding a biological sample and comprising at least one chamber, the interior of which is not fluidically connected to the holding space and is filled only partially with an indicator substance, the melting temperature of which lies in a range of 20 C. to 140 C. In particular, the chamber can be formed by a container that is detachably or pivotably fastened to the sample container. Alternatively, the chamber is formed by a double-walled slide-on part or the holding space of the sample container is double-walled, wherein an intermediate space between the inner wall and the outer wall is partially filled with the indicator substance.

The invention relates to a device for the temperature monitoring of a cryopreserved biological sample, comprising a sample container having an accommodating space (2) for accommodating the sample and comprising an indicating apparatus, which can be arranged on the outside of the sample container, for monitoring at least one temperature limit value. The indicating apparatus has at least one cavity, which is only partially filled with an indicating substance, the melting temperature of which lies in a range from 20 C. to 140 C. The indicating apparatus can be designed, in particular, as a cylindrical body, which can be fastened to a cryotube as a bottom part, or alternatively as a double-walled hollow cylinder, which can be slid onto an outer lateral surface of the cryotube. The indicating apparatus can also be fastened to a lateral outer wall of the sample container, e.g. as a hollow body that can be inserted into a sleeve or insertion pocket.

Automatic devices configured to perform a cryoprocedure on at least one biological sample carried by one or more carriers. The device includes a carrier holder, a container holder, a carrier driver and a container driver. The carrier holder holds the one or more carriers in an upright orientation while holding the at least one biological sample. The container holder holds two or more containers each in a predetermined location on the container holder. The carrier driver translates the carrier holder and the container driver translates the predetermined locations so as to position one of them in a position accessible to the carrier holder, so as to enable the carrier driver to submerge an active portion of each one or more carriers held by the carrier holder in a predetermined vertical depth in the position accessible to the carrier holder.

A cryogenic device for vitrifying, storing, and thawing biological materials, comprises a loading and retrieving arrangement, wherein the loading and retrieving arrangement comprises a vitrification and thawing sub-arrangement further comprising a housing having an openable door and a second carousel-shaped member rotatably disposed therewithin; the second carousel-shaped member carries containers configured for accommodating vitrifying or thawing consumables for vitrifying or thawing biological material containers to be placed into or retrieved from the cryogenic environment and at least one heater for heating the thawing consumable to a predefined temperature for complying with a given thawing protocol; the second carousel-shaped member has a side recess providing an access of the linear manipulator to the receptacles carried by the first carousel-shaped member; wherein the method comprises a step of linearly moving the second carousel-shaped member between first and second positions.