The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: ##STR00001##
wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, n.sub.1, m, p Z.sub.1, Z.sub.2, and Z.sub.3 are as described in the specification. The invention also relates to compounds of formula (I) which are antagonists of the motilin receptor and are useful in the treatment of disorders associated with this receptor and with or with motility dysfunction.

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One). ##STR00001##

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One).

##STR00001##

Systems and methods related to the formation of a reaction product on a surface are generally provided. The systems and methods described herein may allow for collection of the retention of a fluid by a surface in a relatively high amount. Such systems and methods may be useful in various applications including, for example, agriculture. In some embodiments, the systems and methods enhance water retention on hydrophobic surfaces of plants. Advantageously, the methods described herein may, in some cases, result in the formation of reaction products on a surface that serve to prevent fluids from being removed from the surface. Advantageously, the systems and methods described herein may suppress the adverse effects of natural conditions such as high surface energies and wind.

Systems and methods related to the formation of a reaction product on a surface are generally provided. The systems and methods described herein may allow for collection of the retention of a fluid by a surface in a relatively high amount. Such systems and methods may be useful in various applications including, for example, agriculture. In some embodiments, the systems and methods enhance water retention on hydrophobic surfaces of plants. Advantageously, the methods described herein may, in some cases, result in the formation of reaction products on a surface that serve to prevent fluids from being removed from the surface. Advantageously, the systems and methods described herein may suppress the adverse effects of natural conditions such as high surface energies and wind.

Described herein are orodispersible films comprising a film forming hydrophobic polymer, a disintegrant, a plasticizer and a stabilizer.

Embodiments of the present disclosure relate to compositions for controlling pests, the compositions including a pyrone in combination with a pyrethroid, a neonicotinoid, an organophosphate, and/or an enzyme inhibitor. Also provided herein are methods of making and using the compositions for controlling pests, such as insects, arachnids, and larvae.

Embodiments of the present disclosure relate to compositions for controlling pests, the compositions including a pyrone in combination with a pyrethroid, a neonicotinoid, an organophosphate, and/or an enzyme inhibitor. Also provided herein are methods of making and using the compositions for controlling pests, such as insects, arachnids, and larvae.