This invention relates to compositions and medical devices comprising anti-microbial active particles, for inhibiting microbial growth. This invention further provides methods of making such compositions and medical devices.

This invention relates to compositions and medical devices comprising anti-microbial active particles, for inhibiting microbial growth. This invention further provides methods of making such compositions and medical devices.

Provided is an antimicrobial photoreactive composition comprising a photocatalytic multijunction composite that is photoreactive in ordinary room lighting and comprises at least one photocatalytic heterojunction that is primarily carbon based. The composition further comprises at least one surface-coupling material, optionally at least one additive selected from a charge-transfer augmenting material, a light-capturing augmenting material, an antimicrobial augmenting material(s), or a combination thereof, and a carrier. The composition can be coupled to a surface or embedded in a cationic polymer matrix to form an antimicrobial film that is removable. Further provided is a method of disinfecting a surface comprising applying the antimicrobial photoreactive composition to a surface.

Provided is an antimicrobial photoreactive composition comprising a photocatalytic multijunction composite that is photoreactive in ordinary room lighting and comprises at least one photocatalytic heterojunction that is primarily carbon based. The composition further comprises at least one surface-coupling material, optionally at least one additive selected from a charge-transfer augmenting material, a light-capturing augmenting material, an antimicrobial augmenting material(s), or a combination thereof, and a carrier. The composition can be coupled to a surface or embedded in a cationic polymer matrix to form an antimicrobial film that is removable. Further provided is a method of disinfecting a surface comprising applying the antimicrobial photoreactive composition to a surface.

A presaturated wiping product is disclosed well suited for destroying non-enveloped viruses, including the Norovirus. The wiping composition contains a first anti-microbial agent blended with a second agent, such as a preservative. Even at very low concentrations within the wiping composition, the wiping products can completely destroy and kill non-enveloped viruses at relatively short contact times.

A presaturated wiping product is disclosed well suited for destroying non-enveloped viruses, including the Norovirus. The wiping composition contains a first anti-microbial agent blended with a second agent, such as a preservative. Even at very low concentrations within the wiping composition, the wiping products can completely destroy and kill non-enveloped viruses at relatively short contact times.

A presaturated wiping product is disclosed well suited for destroying non-enveloped viruses, including the Norovirus. The wiping composition contains a first anti-microbial agent blended with a second agent, such as a preservative. Even at very low concentrations within the wiping composition, the wiping products can completely destroy and kill non-enveloped viruses at relatively short contact times.

Topical antiseptic rubs are disclosed that reduce microorganism loading on the skin surface preventing possible infections. The FDA currently recognizes ethanol, isopropanol and benzalkonium chloride as active ingredients but further defines the actives as chronic use drugs. The present invention describes formulations and applications of a liquid compound that forms a topical polymeric skin layer consisting of a given benzalkonium chloride concentration within the matrix, which quickly reduces all bacteria including the MERS, virus types, and kills spores including the Clostridium difficile. The second skin concept, is likened to the human skin cellular function of the stratum corneum, functions as a barrier to exogenous substances, which reduces any chronic flux of benzalkonium chloride into the epidermis and reducing symptoms of constant usage. The second skin polymeric application agglomerates, traps and kills bacteria. The second skin provides for cosmetic moisturizing, barrier effects and skin softness.

Topical antiseptic rubs are disclosed that reduce microorganism loading on the skin surface preventing possible infections. The FDA currently recognizes ethanol, isopropanol and benzalkonium chloride as active ingredients but further defines the actives as chronic use drugs. The present invention describes formulations and applications of a liquid compound that forms a topical polymeric skin layer consisting of a given benzalkonium chloride concentration within the matrix, which quickly reduces all bacteria including the MERS, virus types, and kills spores including the Clostridium difficile. The second skin concept, is likened to the human skin cellular function of the stratum corneum, functions as a barrier to exogenous substances, which reduces any chronic flux of benzalkonium chloride into the epidermis and reducing symptoms of constant usage. The second skin polymeric application agglomerates, traps and kills bacteria. The second skin provides for cosmetic moisturizing, barrier effects and skin softness.

A composition and method for inducing and inflicting damage to cell membranes of microorganism by inducing changes in membrane permeability caused by polycation-induced membrane pores. The control of Clostridium difficile spores with an efficacy of 99.99% on hard surfaces is provided. The invention includes the application of an evaporation-induced self-assembly, surfactant-mediated synthesis or self-condensing polymer, which forms a film which is both flexible on the surface as a nano-polymeric coating and with refractive index yielding a transparent coating. The polymeric matrix includes various biocidal polymeric cationic quaternary salts, one being a silyl quaternary having a kinetic zeta potential to disrupt bacterial spores functions. The polymeric matrix consist of multiple small molecule biocides as well as polymerics biocide combinations not otherwise seen to develop an surface topography of peaks and troughs in the nano range to resist bacterial adhesion factors and subsequent biofilm formation. The surfactants induce self-assembly film topography.