Antibacterial compositions comprising at least one unsaturated fatty acid or a pharmaceutically acceptable salt thereof; at least one alpha-hydroxy acid or a pharmaceutically acceptable salt thereof; and at least one amino alcohol. The compositions have broad-spectrum antibacterial activity, including on pathogens displaying multi-drug resistance.

In one aspect, the present disclosure relates to click-functional antimicrobial molecules (including small molecules or, in some cases, macromolecules) and the construction of antimicrobial polymers such as polyurethanes, polyesters, and polyacrylates, including through the use of such molecules. In some cases, the antimicrobial click-functional molecules are based on 1,2-benzisothiazolin-3-one (BIT), trimethylguanidine or tetramethylguanidine (TMG), polyhexamethylene guanidine (PHMG), fluorine-containing molecules, or a combination thereof. For example, 1,2-benzisothiazolin-3-one (BIT) functionalized with an alkyne (BIT-Al), trimethylguanidine or tetramethylguanidine (TMG) functioned with an alkyne (TMG-Al) or dual alkynes (TMG-dAl), and/or polyhexamethylene guanidine (PHMG) functionalized with an alkyne (PHMG-Al) are described herein. Clickable antimicrobial polymers can be used to form coatings or films.

In one aspect, the present disclosure relates to click-functional antimicrobial molecules (including small molecules or, in some cases, macromolecules) and the construction of antimicrobial polymers such as polyurethanes, polyesters, and polyacrylates, including through the use of such molecules. In some cases, the antimicrobial click-functional molecules are based on 1,2-benzisothiazolin-3-one (BIT), trimethylguanidine or tetramethylguanidine (TMG), polyhexamethylene guanidine (PHMG), fluorine-containing molecules, or a combination thereof. For example, 1,2-benzisothiazolin-3-one (BIT) functionalized with an alkyne (BIT-Al), trimethylguanidine or tetramethylguanidine (TMG) functioned with an alkyne (TMG-Al) or dual alkynes (TMG-dAl), and/or polyhexamethylene guanidine (PHMG) functionalized with an alkyne (PHMG-Al) are described herein. Clickable antimicrobial polymers can be used to form coatings or films.

Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.

Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.

A topical sanitizing composition for reducing the concentration of non-enveloped viruses on the skin is provided. The topical sanitizing composition includes one or more pH adjusters, at least one carbomer, and at least about 50 wt. % of one or more C.sub.1-8 alcohols. The sanitizing composition with pH adjuster and carbomer is able to achieve at least a 3.0 log reduction in the concentration of the non-enveloped virus and in some cases passes the EN 14476 standard.

A topical sanitizing composition for reducing the concentration of non-enveloped viruses on the skin is provided. The topical sanitizing composition includes one or more pH adjusters, at least one carbomer, and at least about 50 wt. % of one or more C.sub.1-8 alcohols. The sanitizing composition with pH adjuster and carbomer is able to achieve at least a 3.0 log reduction in the concentration of the non-enveloped virus and in some cases passes the EN 14476 standard.

The present invention provides an improved process for preparing DTEA HCl from decene and cysteamine HCl by using a catalyst, solvent and a co-solvent to aid the reaction and provide low temperature stabilization of the resulting product solution.

The present invention provides an improved process for preparing DTEA HCl from decene and cysteamine HCl by using a catalyst, solvent and a co-solvent to aid the reaction and provide low temperature stabilization of the resulting product solution.

Disclosed herein is a stable, encapsulated reactive amine composition, having a particle size about 100 microns or less comprising; water soluble amine; polymeric surfactant/stabilizer; polyisocynate; and fumed silica; wherein, the reactive amine is released from the encapsulated amine in aqueous and non-aqueous environment, for use in industries such as painting, cosmetics, paper, lubricants, printing, plastics, petrochemicals etc. Further, the invention provides process for the preparation of stable microcapsule composition, without converting the water soluble amine into its salt or adduct and its characterization thereof.