Provided relates to pharmaceutically acceptable salts of conjugates including a chemotherapeutic drug and an amino acid or a derivative thereof, which are readily taken up by a target cell and reduce side effects induced by the chemotherapeutic drug. Further, the subject matter relates to pharmaceutically acceptable salts of conjugates comprising cytidine analog drugs and aspartic or glutamic acid and analogs thereof, pharmaceutical compositions including these conjugates and use thereof for the treatment of cancer or a pre-cancer condition or disorder.

The invention relates to compounds that are useful in the treatment of parkinsonism, such as parkinsonism in connection with Parkinson's disease (PD); dementia with Lewy bodies (DLB); multiple system atrophy (MSA); corticobasal degeneration (CBD); or progressive supranuclear palsy (PSP). The said compounds include in particular idoxuridine and analogs thereof as well as their metabolic precursors, such as ropidoxuridine. The invention further relates to method for identifying compounds useful for the treatment of parkinsonism, said methods comprising detecting the capability of compound to increase the amount of GPR37 in cell membranes. The invention further relates to methods for the chemical synthesis of ropidoxuridine.

The invention provides derivatives of decitabine with superior chemical stability and shelf life, with similar physiological activity. The derivatives are provided in a non-aqueous formulation, which further stabilizes the derivatives. Methods of treating one or more myelodysplastic syndromes, leukemia, or solid tumours using the formulations are described.

The present invention relates to compositions and methods of treating lysosomal storage diseases and methods of using trehalose.

Certain embodiments of the invention provide a method for breast enhancement in a female mammal (e.g., a human) in need thereof, comprising administering an effective amount of a nicotinamide adenine dinucleotide (NAD) precursor to the mammal.

The present invention provides a method for rapid, highly specific and sensitive detection and quantification of a virus by observing viral substrate binding to its host receptor protein. The invention also provides a method for rapid, highly specific and sensitive detection and quantification of a virus in an individual suspected of being infected with a virus. The invention further provides a test kit for rapid, highly specific and sensitive point-of-care detection of a virus in an individual. The viruses and their host receptor proteins that can rapidly be detected include SARS-CoV-2 and its host receptor protein ACE2. The surprisingly rapid, specific and sensitive method and kit of the invention provide a point-of care test capable of diagnosing individuals suffering from COVID-19 by observation of a color change in the assay, which color change occurs in about five minutes, and which test can be completed by a user in about 60 minutes.

Provided herein are safened herbicidal compositions for use in Brassica species susceptible to injury by halauxifen comprising (a) a herbicidally effective amount of halauxifen or an agriculturally acceptable salt or ester of thereof, and (b) one or more of (i) a herbicide[s], capable of safening the halauxifen to the Brassica species, or an agriculturally acceptable salt or ester thereof, or (ii) a herbicide safener, capable of safening the halauxifen to the Brassica species, or an agriculturally acceptable salt or ester thereof.

Provided herein are safened herbicidal compositions for use in Brassica species susceptible to injury by halauxifen comprising (a) a herbicidally effective amount of halauxifen or an agriculturally acceptable salt or ester of thereof, and (b) one or more of (i) a herbicide[s], capable of safening the halauxifen to the Brassica species, or an agriculturally acceptable salt or ester thereof, or (ii) a herbicide safener, capable of safening the halauxifen to the Brassica species, or an agriculturally acceptable salt or ester thereof.

Provided herein are safened herbicidal compositions for use in Brassica species susceptible to injury by halauxifen comprising (a) a herbicidally effective amount of halauxifen or an agriculturally acceptable salt or ester of thereof, and (b) one or more of (i) a herbicide[s], capable of safening the halauxifen to the Brassica species, or an agriculturally acceptable salt or ester thereof, or (ii) a herbicide safener, capable of safening the halauxifen to the Brassica species, or an agriculturally acceptable salt or ester thereof.

Contemplated compositions and methods employ betalains for treatment of various conditions, and especially osteoarthritis, sinusitis, contact dermatitis, acne, an allergic condition, reduced mental alertness, reduced physical strength, reduced physical endurance, and/or impaired mood.