Provided herein are, inter alia, biological manufacturing and downstream purification processes.

A device for collecting contaminants from water samples is provided. The device includes a solid sorbent that collects and stores the contaminants from water samples. The solid sorbent is configured to allow for the preservation of the stored contaminants. The concentrations of the contaminants in the water samples are determined via analysis of the solid sorbent or via elution of the stored contaminants from the sorbent and analysis of the eluate solution.

The invention relates to a method for separating natural substance mixtures, in particular those consisting of plant extracts, and for isolating and purifying and obtaining same, by means of sequential centrifugal partition chromatography (sCPC).

A device for collecting contaminants from water samples is provided. The device includes a solid sorbent that collects and stores the contaminants from water samples. The solid sorbent is configured to allow for the preservation of the stored contaminants. The concentrations of the contaminants in the water samples are determined via analysis of the solid sorbent or via elution of the stored contaminants from the sorbent and analysis of the eluate solution.

A method for continuous exchange of material includes countercurrent contacting of a first fluid phase and a second fluid phase that are not completely miscible. The contacting is carried out in a single centrifugal partition chromatography (CPC) apparatus into which only the first and second fluid phases introduced. The apparatus includes a plurality of cells, each with a stationary phase immobilized and a mobile phase passing through the stationary phase. The following steps are carried out successively: a) the mobile phase is formed by the first fluid phase, and the stationary phase immobilized in the cells is formed by the second fluid phase; b) the mobile phase is formed by the second fluid phase, and the stationary phase immobilized in the cells is formed by the first fluid phase; c) repetition of the succession of steps a) and b) each step being carried out immediately after the preceding step.

A rotor for all systems used to circulate various single-phase or multiphase fluids, ranging from organic or non-organic solvents to CO.sub.2 in a liquid or supercritical phase in cells connected to each other by channels, the assembly being subjected to adjustable centrifugal acceleration and including precision temperature control for chemical or biochemical reactions and extractions, and purification and separation reactions and, for use in chemical and biochemical reactors. Such a rotor is formed of one or more discs stacked on top of each other, each being made up of circular sectors consisting of a circular half-sector and a circular half-sector, each being the mirror image of the other relative to the plane of the circular half-sector after they have been assembled opposite each other in a sealed manner. Their half-channels having respective links which form a link channel when the half-sectors are joined.

Provided herein are, inter alia, biological manufacturing and downstream purification processes.

An extraction cell (10) for a centrifugal partition chromatograph (20), which extraction cell (10) contains an extraction chamber (12) delimited by a cell wall (12c) and accommodates the liquid stationary phase (30á), and it has a liquid inlet opening (13b) and a liquid outlet opening (13k) serving to let in and out the liquid mobile phase (30m) to be made to flow through the extraction cell (10). The extraction cell (10) contains an extraction chamber (12) established as a tubular body, and a liquid inlet plug (16b) that includes a liquid inlet opening (13b) and a liquid outlet plug (16k) that includes a liquid outlet opening (13k), that can be attached to the extraction chamber (12) and an insert (14) through which liquids may pass is positioned in the extraction chamber (12) between the liquid inlet opening (13b) and the liquid outlet opening (13k). A further objective relates to a centrifugal partition chromatograph (20) containing such an extraction cell (10), and a method for providing such an extraction cell (10).

Provided herein are, inter alia, biological manufacturing and downstream purification processes.

The invention relates to cannabinoids and their isolation and purification and to obtaining them by means of centrifugal partition chromatography.