Disclosed herein are embodiments of a polymer-functionalized particle for using in isolating and extracting solutes, such as rare earth metals, lithium, and the like. The polymer-functionalized particles exhibit strong resistance to agglomeration and degradation even in high ionic strength and/or temperature environments. A post-particle synthesis method for making the polymer-functionalized particle is disclosed, along with a magnetic separation device and that can be used in system embodiments to facilitate use and regeneration of the polymer-functionalized particles in solute extraction.

The present disclosure provides methods for purifying a recombinant AAV (rAAV) vector from a solution by affinity chromatography to produce an eluate enriched for AAV vectors (rAAV vectors).

The invention relates to upstream and/or downstream processes of selectively reducing one or more unpaired cysteines of a monoclonal antibody, whilst keeping conserved inter- and intra-molecular disulfide bonds elsewhere in the antibody intact. The invention further relates to purified antibodies obtained by the methods as described herein.

Disclosed is a method for removing factor XI (FXI) during plasma protein purification, more specifically a method for removing FXI including dialyzing and concentrating a plasma protein fraction II paste containing FXI and a plasma protein, and then removing the FXI using a ceramic-based cation exchange resin. The method for removing factor XI (FXI) can improve removal efficiency of impurities and thrombogenic substances, thereby producing stable plasma proteins with improved quality.

The present invention provides a novel process for desalting protein solutions using micropore anion and cation exchange resins. In addition, a continuous process for desalting biopharmaceutical solutions was developed. Devices for use in the process for desalting biopharmaceutical solutions were also developed.

The present disclosure provides processes and systems for dehydrating a byproduct stream in ethanol production. In one embodiment, a feed mixture is distilled with one or more distillation units to remove at least a portion of the water, and form a first byproduct stream. The first byproduct stream is contacted with a molecular sieve unit, thereby forming a product stream. The molecular sieve unit is cyclically contacted with at least a portion of the product stream to regenerate the molecular sieve unit and form one or more regenerate streams. A second byproduct stream including at least one of (1) the regenerate streams and (2) at least a portion of the fusel oil stream is contacted with a separation system, thereby forming a permeate and a retentate. At least a portion of the retentate is forwarded into the product stream.

The present disclosure relates to an onshore lithium-recovering device for a lithium ion adsorption and desorption process including a supply unit for supplying lithium-containing water in which lithium is dissolved, a composite unit, a washing unit, a desorbing liquid unit, an extract liquid unit, a pressure adjusting unit, a discharge unit, and a control unit. Therefore, the lithium adsorption means is moved onshore so it is possible to significantly reduce the plant installation cost and the operating cost as compared to the lithium recovery process that operates the conventional offshore plant.

A water softener apparatus comprises two water softener tanks one of which is always operating, valves controlling the flow of water and a flow-meter, wherein, after a set volume of water has passed through one tank, water is passed through the other tank. The apparatus uses ion-exchange tanks which may be regenerated by brine when not softening hard water. The flow-meter preferably comprises an actuator which moves in a cyclic movement in response to the flow of a set quantity of water and actuates two service valves which send pressured water signals to a drain shuttle valve. The drain shuttle valve then diverts hard water from one tank to another and initiates regeneration of the first tank. A regeneration meter terminates the alternate regeneration of the two tanks. The regeneration meter is positioned in the apparatus of a point where brine for regeneration of the two water softener components is received into the apparatus.

The present disclosure provides processes and systems for ethanol production. In one embodiment, a first beer column receives a first portion of a feed mixture including ethanol and water to form a first beer column bottom stream and a first beer column vaporous overhead stream. A beer column receives a second portion of the feed mixture. A first portion of the first beer column bottom stream is forwarded to a first beer column reboiler. A second portion of the first beer column bottom stream is forwarded to a plurality of evaporators. A condensed portion of the first beer column vaporous overhead stream is forwarded to a stripper column. The stripper column forms a feed stream, which is contacted with a separation system, thereby forming a permeate and a retentate. The permeate is forwarded directly to at least one selected from the first beer column and the stripper column.

The present invention relates to a cation exchange chromatography process for the purification of enteroviruses.