A system, module and method for continuous or batch single-pass countercurrent tangential chromatography are disclosed for bind/elute and negative chromatography applications. The system includes binding, washing, elution (for bind/elute), regeneration, and equilibration single-pass modules. The resin slurry flows in a continuous single pass at steady-state through each module, while corresponding buffers flow countercurrent to the slurry facilitating efficient product and impurity extraction. The module and system include retentate pumps for better process robustness and control. A resin tank configured to be reversibly isolated from the single-pass modules facilitates a closed and disposable system. The method includes receiving unpurified product solution and resin slurry, isolating the resin tank, binding product (bind/elute) or impurities (negative) to the resin slurry, washing impurities from the resin slurry, eluting and capturing pure product from the resin slurry (bind/elute), regenerating the resin slurry following elution, and providing buffer solutions to all of the single-pass steps.

A material includes a porous particle that includes a metal ion imprinted polymer. The metal ion imprinted polymer is formed from a hydrophilic co-monomer, a metal containing polymerizable compound, and a cross-linking agent. The metal containing polymerizable compound includes at least one metal chelating ligand. The metal ion imprinted polymer includes a plurality of metal ion selective binding sites. A method includes flowing brine containing a metal ion through a reactor that includes the material. The method further includes discharging the brine from the reactor, contacting the porous particles with water, and pressurizing the reactor with carbon dioxide. The carbon dioxide reacts with the adsorbed metal ions to form a metal carbonate solution. The method further includes depressurizing the reactor to precipitate metal carbonate from the metal carbonate solution and discharging the metal carbonate solution from the reactor.

Disclosed is a method for identifying the accurate number of peaks which includes a peak extraction process of extracting a number of target peaks corresponding to a number of target components to be identified, among the multiple components from a group of peaks appearing on the chromatogram, a peak identification process that assigns names of the target components to the target peaks in descending or ascending order of first retention time, based on a standard sample timetable preloaded with a relationship between the names of the target components and the corresponding first retention times, which are retention times of the target components, is stored, and a standard sample timetable updating process that updates the first retention times in the standard sample timetable, with second retention times that are measured retention times of the target peaks.

Processes, apparatuses, and systems for the production, separation and purification of radioisotopes for medical, industrial, agricultural, and energy applications are disclosed. The following operations are performed: selective adsorption of at least one radionuclide to a solid support and desorption of the at least one absorbed radionuclide by evaporation; or electrochemical separation of the at least one radionuclide by electrochemically depositing either the at least one radionuclide or the target material on a metallic electrode; or removing the target material by high temperature sublimation under vacuum or in an inert atmosphere, if the at least one radionuclide is less volatile than the target material.

Processes and apparatuses for degrading PFAS into calcium fluoride, carbon dioxide, and water. PFAS are heated and introduced to a calcium base which will degrade the PFAS. The PFAS may be in a stream that is a PFAS enriched stream formed by desorbing the PFAS from an adsorbent which removed the PFAS from a contaminant stream. The PFAS may be desorbed in the presence of the calcium base. The calcium base may be calcium hydroxide, calcium oxide, calcium carbonate, or combinations thereof.

Separation media that includes a support substrate and a plurality of separation ligands immobilized on the support substrate. The plurality of separation ligands include an affinity capable of recognizing and binding to blood type antigen recognizing domain. Methos of making the separation media and methods of using the separation media.

Methods and systems are disclosed for selectively removing naturally-occurring sugars in beverages in an effective, affordable and scalable manner.

An apparatus for removing proteins taken up in a carrier liquid, which includes a granular adsorbent for proteins. Also, a method for removing proteins taken up in a carrier liquid, with a corresponding apparatus. Further, the use of a corresponding apparatus, for extracting proteins from a liquid and more particularly from an unclarified feedstock.

Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.

A system and method that includes flowing brine containing a metal ion through a reactor that includes porous particles having metal ion imprinted polymer having selective binding sites. The system and method further include discharging the brine from the reactor, contacting the porous particles with water, and pressurizing the reactor with carbon dioxide. The carbon dioxide reacts with the adsorbed metal ions to form a metal carbonate solution, where the metal carbonate solution can then be continuously purified with ion exchange. The method can include recycling eluent from the ion exchange back into the system for re-use. The method further includes depressurizing the reactor to precipitate metal carbonate from the metal carbonate solution and discharging the metal carbonate solution from the reactor.