An electrochemical separation device includes a first electrode, a second electrode, and a cell stack including a plurality of sub-blocks each having alternating depleting compartments and concentrating compartments and each including frame and channel portions disposed between the first electrode and the second electrode. An internal seal formed of a first material is disposed between and in contact with the channel portions between adjacent sub-blocks in the cell stack and configured to prevent leakage between depleting compartments and concentrating compartments in the adjacent sub-blocks. An external seal formed of a second material having at least one material parameter different from the first material is disposed between and in contact with the frames of the adjacent sub-blocks in the cell stack and configured to prevent leakage from an internal volume of the electrochemical separation device to outside of the electrochemical separation device.

Hemofilters for in vivo filtration of blood are disclosed. The hemofilters disclosed herein provide an optimal flow of blood through the filtration channels while maintaining a pressure gradient across the filtration channel walls to enhance filtration and minimize turbulence and stagnation of blood in the hemofilter.

An example separation system includes a stack of membrane plate assemblies. An example membrane plate assembly may include membranes bonded to opposite sides of a spacer plate. The spacer plate may include a first opening in fluid communication with a region between the membranes, and a second opening in fluid communication with a region between membrane plate assemblies. Adjacent membrane plate assemblies in the stack may have alternating orientations such that bonding areas for adjacent membranes in the stack may be staggered. Accordingly, two isolated flows may be provided which may be orthogonal from one another.

Disclosed are various turbulent, corrosion-resistant heat exchangers used in desiccant air conditioning systems.

The present disclosure provides an electrodialysis stack that may be used for the treatment of an electrically conductive solution. The stack includes two electrodes (at least one is a recessed electrode), a plurality of ion-transport membranes and stack spacers. The membranes and spacers are arranged between the electrodes to define electrodialysis cell pairs. The stack includes an electrically insulated zone that extends substantially from a distribution manifold past the recessed edge of the electrode and substantially from the recessed electrode to the opposite electrode for a distance that is about 8% to 100% of the total distance between the electrodes. The overlap distance that the electrically insulated zone extends past the recessed edge of the electrode is calculated as:

distance in cm=(0.062 cm.sup.?1)*(exp(?60/total cp)*(area in cm.sup.2 of the manifold ducts of the concentrated stream at the recessed edge)+/?10%.

Systems and methods for single-pass, countercurrent diafiltration of a fluid feed are provided. The systems and methods operate to reduce impact on the biologic product, reduce use of diafiltration buffer and reduce equipment size compared to traditional systems.

A humidifier for transferring water vapor from a first gas stream to a second gas stream in a fuel cell system has a stack of thin plates joined together at their edges by planar sealing surfaces, with water permeable membranes between the plates. Each plate defines a gas flow passage along its top and bottom surfaces, with an inlet and outlet defined along edges of the plate, and a flow field extending between the inlet and outlet openings. Inlet and outlet passages connect the inlet and outlet openings to the flow field, with the planar sealing surfaces including bridging portions extending across these passages. Support structures are provided throughout the flow field to support the membrane and diffusion medium layer(s). Each support structure comprises a porous material which is sufficiently porous to permit gas flow through the flow field.

An electrochemical separation device includes a first electrode, a second electrode, and a cell stack including a plurality of sub-blocks each having alternating depleting compartments and concentrating compartments and each including frame and channel portions disposed between the first electrode and the second electrode. An internal seal formed of a first material is disposed between and in contact with the channel portions between adjacent sub-blocks in the cell stack and configured to prevent leakage between depleting compartments and concentrating compartments in the adjacent sub-blocks. An external seal formed of a second material having at least one material parameter different from the first material is disposed between and in contact with the frames of the adjacent sub-blocks in the cell stack and configured to prevent leakage from an internal volume of the electrochemical separation device to outside of the electrochemical separation device.

A stack plate of a stack plate device of a humidifier includes inlay parts extending along two opposing front or longitudinal ends of the stack plate, a semipermeable layer disposed on and being stabilized by the inlay parts, and a frame disposed on multiple portions of the semipermeable layer that are disposed on the inlay parts, the frame circumferentially enclosing a through-opening in the stack plate. A remaining portion of the semipermeable layer completely covers the through-opening. An outer circumferential section of the semipermeable layer and the inlay parts are overmolded by the frame. Opposing front ends of the frame define inflow and outflow regions, respectively, on a first side of the frame for a second fluid, and opposing longitudinal ends of the frame define inflow and outflow regions, respectively, on a second side of the frame for a first fluid.

Parallel plate devices for hemofiltration or hemodialysis are provided. A parallel plate device includes a parallel plate assembly having an aligned stack of stackable plate subunits, each stackable plate subunit having a through channel for blood, where the blood channels are opened up at opposite ends of the parallel plate assembly. The parallel plate assembly is configured to form filtrate/dialysate channels interleaved with the blood channels, adjacent channels being separated by a silicon nanoporous filtration membrane. A blood conduit adaptor is attached to the parallel plate assembly at each of the ends, and is configured to distribute blood to or collect blood from the blood channels. Also provided are systems and methods for using the parallel plate devices.