Embodiments of the invention involve treating skin afflictions by the topical or oral use of organophosphates. By effectively reducing or eliminating the population of Demodex mites in affected skin areas and areas where Demodex mites may exist, this treatment achieves a more complete remission of clinical signs and symptoms of the skin afflictions than any previously described method. Embodiments of the invention are useful for treating skin afflictions including common acne, seborrheic dermatitis, perioral dermatitis, an acneform rash, transient acantholytic dermatosis, acne necrotica milliaris, psoriasis, steroid induced dermatitis, primary irritation dermatitis, rosacea and for diagnositic methods thereof.

Embodiments of the invention involve treating skin afflictions by the topical or oral use of organophosphates. By effectively reducing or eliminating the population of Demodex mites in affected skin areas and areas where Demodex mites may exist, this treatment achieves a more complete remission of clinical signs and symptoms of the skin afflictions than any previously described method. Embodiments of the invention are useful for treating skin afflictions including common acne, seborrheic dermatitis, perioral dermatitis, an acneform rash, transient acantholytic dermatosis, acne necrotica milliaris, psoriasis, steroid induced dermatitis, primary irritation dermatitis, rosacea and for diagnositic methods thereof.

Preparation of O,O-dimethyl phosphoramidothioate and O,O-dimethyl phosphoroamidothioate. A process of making O,O-dimethyl phosphoroamidothioate is described including reacting sulfur with PCl.sub.3 to form PSCl.sub.3, reacting the PSCl.sub.3 formed with methanol to form O-methyl phosphorodichloridothioate, and reacting the O-methyl phosphorodichloridothioate formed with methyl lye to form O,O-dimethyl phosphorochloridothioate in solution in CH.sub.2Cl.sub.2, and reacting the O,O-dimethyl phosphorochloridothioate formed with sodium hydroxide and ammonium hydroxide to form O,O-dimethyl phosphoroamidothioate in solution in CH.sub.2Cl.sub.2. Reacting the O,O-dimethyl phosphoroamidothioate formed with catalytic dimethyl sulfate to form methamidophos, and reacting the methamidophos formed with acetic anhydride to form N-(methoxy-methylsulfanylphosphoryl) acetamide is also described. Throughout the process, the O,O-dimethyl phosphorochloridothioate and the O,O-dimethyl phosphoroamidothioate formed are maintained in solution in CH.sub.2Cl.sub.2 at all times.

An agrochemical composition comprising at least one low melting active ingredient; at least one moisture sensitive active ingredient; and an additive, characterised in that said additive has a softening point or melting point lower than the melting point of said low melting active ingredient; a process for the preparation thereof, a method of use thereof and a kit comprising the same is disclosed.

An agrochemical composition comprising at least one low melting active ingredient; at least one moisture sensitive active ingredient; and an additive, characterised in that said additive has a softening point or melting point lower than the melting point of said low melting active ingredient; a process for the preparation thereof, a method of use thereof and a kit comprising the same is disclosed.

An agrochemical composition comprising at least one low melting active ingredient; at least one moisture sensitive active ingredient; and an additive, characterised in that said additive has a softening point or melting point lower than the melting point of said low melting active ingredient; a process for the preparation thereof, a method of use thereof and a kit comprising the same is disclosed.

Organophosphorus or organosulfur compounds and methods of using the compounds as cleaning agents, particle dispersants, or surfactants, or to remove, disperse or inhibit the growth of a biofilm, or inhibit the growth of, or kill a fungus or bacteria are provided.

Organophosphorus or organosulfur compounds and methods of using the compounds as cleaning agents, particle dispersants, or surfactants, or to remove, disperse or inhibit the growth of a biofilm, or inhibit the growth of, or kill a fungus or bacteria are provided.

The present disclosure relates to formulations comprising a urease inhibitor with improved stability against crystallization and/or freezing upon exposure to low temperatures, such as for example, 0 C. or below. The present disclosure also provides methods to make and use such a formulation.

The present disclosure relates to formulations comprising a urease inhibitor with improved stability against crystallization and/or freezing upon exposure to low temperatures, such as for example, 0 C. or below. The present disclosure also provides methods to make and use such a formulation.