Provided herein is a method for preparing microcarrier particles, comprising the steps of allowing the dispersed phase liquid flow through a multi-hole plate at a low temperature to form liquid microspheres in a continuous phase, and enabling a synthetic polymer and/or natural biological macromolecules within the liquid microspheres to be subject to a curing reaction at a low temperature to form particles. Further provided herein are the method for preparing an emulsion and an apparatus and process system for preparing microcarrier particles, which can be used for preparing emulsions and microcarrier particles on a large scale.

The present invention relates to biocompatible microemulsion systems designed for controlled release drug delivery applications formulated with phospholipids such as lecithin (surfactant), a lipophilic additive (linker) containing 9 or more carbons in their alkyl group and hydrophilic-lipophilic balance (HLB) of 5 or less, and a surfactant-like hydrophilic additive (linker) containing between 6 to 9 carbon atoms in their alkyl tail. The combination of linkers and phospholipids produce formulations capable of delivering high concentrations of poorly soluble drugs into epithelial tissue using low surfactant concentrations, with minimum cytotoxic side effects.

The present invention generally relates to microparticles and, in particular, to systems and methods for encapsulation within microparticles. In one aspect, the present invention is generally directed to microparticles containing entities therein, where the entities contain an agent that can be released from the microparticles, e.g., via diffusion. In some cases, the agent may be released from the microparticles without disruption of the microparticles. The entities may be, for instance, polymeric particles, hydrogel particles, droplets of fluid, etc. The entities may be contained within a fluid that is, in turn, encapsulated within the microparticle. The agent may be released from the entity into the fluid, and then from the fluid through the microparticle. In such fashion, the release of agent from the microparticle may be controlled, e.g., over relatively long time scales. Other embodiments of the present invention are generally directed to methods of making such microparticles, methods of using such microparticles, microfluidic devices for making such microparticles, and the like.

An apparatus for membrane emulsification. In one embodiment, the apparatus comprises a membrane defining a plurality of apertures connecting a first phase on a first side of the membrane to a second phase on a second, different side of the membrane, such that egression of the first phase into the second phase via the plurality of apertures creates an emulsion, and wherein the membrane is an oscillating cylindrical membrane.

The present invention provides emulsions as well as compositions and methods for making the same, which are characterized by an ester component, a non-ionic surfactant component and a water component and wherein emulsification using a low or ultra-low energy method such as shaking by hand is possible to obtain a storage stable emulsion with small particle sizes.

Provided is a nano cell block module for homogenizing a solution with a high pressure. The nano cell block module for homogenizing a solution flowing through an inner part with a high pressure includes a first nano cell block 10a comprising at least two flowing passages 14a, 14b extending along a horizontal direction and guiding gaps 15a, 15b guiding the solution flowing along the at least two flowing passages 14a, 14b in a vertical direction; and a second nano cell block 10b comprising a third flowing passage 16 guiding the solution guided along the guiding gaps 15a, 15b in a horizontal direction.

A lipid nanoparticles manufacturing chip includes a first raw material supply flow path, a second raw material supply flow path, and a mixer portion connected to the first raw material supply flow path and the second raw material supply flow path and configured for mixing a first raw material supplied through the first raw material supply flow path and a second raw material supplied through the second raw material supply flow path. The mixer portion includes a first stabilizing unit, and a first mixing unit connected to the first stabilizing unit and configured for mixing the first raw material and the second raw material with each other. Mixing of the first raw material and the second raw material is performed more in the first mixing unit than in the first stabilizing unit.

Method of analysis. In the method, a microfluidic device defining a flow path extending from an inlet to an outlet may be selected. A sample-containing fluid may be introduced into the flow path via the inlet. Volumes of the sample-containing fluid may be isolated from one another on the flow path. A two-dimensional monolayer of the volumes may be imaged. The two-dimensional monolayer may be formed along the flow path between the inlet and the outlet.

The invention provides a microdroplet- or bubble-producing device that does not require separate through-holes for different liquid droplet/air bubble-producing flow channels. The droplet-producing flow channels are configured in a three-dimensional manner unlike in a conventional device where they are configured in a two-dimensional plane, and therefore the flow channels can be provided in a more high-density configuration than the prior art. In the microdroplet/bubble-producing device comprising slit(s) and the row of the plurality of microflow channels, the slit(s) is/are a continuous phase supply slit, a dispersion phase supply slit and a discharge slit, the plurality of microflow channels are configured so that the ends of the slit(s) and the two supply ports on both sides or the supply port and discharge port on either side are mutually connected, and at the sites of connection between the microflow channels and the slit(s), the dispersion phase undergoes shear with the continuous phase flow as the driving force, producing droplets or air bubbles of the dispersion phase, which are recovered from the discharge port.

Disclosed is an ultrasonically-enhanced continuous and large-scale production method for nano-formulations. Specifically disclosed is a preparation system for continuous production of nano-formulations, comprising (a) a first pipe, (b) a second pipe, (f) an ultrasonic device, (c) a combined pipe and (e) a (fluid) outlet thereof. The first pipe and the second pipe are connected to the combined pipe. A first phase solution enters the combined pipe through a first pipe outlet, and a second phase solution enters the combined pipe through a second pipe outlet. The ultrasonic device acts on the part or the whole of the combined pipe. The first phase solution and the second phase solution are turbulently mixed in the combined pipe to form a combined phase, and flow out through the outlet of the combined pipe.