The present invention generally relates to microparticles and, in particular, to systems and methods for encapsulation within microparticles. In one aspect, the present invention is generally directed to microparticles containing entities therein, where the entities contain an agent that can be released from the microparticles, e.g., via diffusion. In some cases, the agent may be released from the microparticles without disruption of the microparticles. The entities may be, for instance, polymeric particles, hydrogel particles, droplets of fluid, etc. The entities may be contained within a fluid that is, in turn, encapsulated within the microparticle. The agent may be released from the entity into the fluid, and then from the fluid through the microparticle. In such fashion, the release of agent from the microparticle may be controlled, e.g., over relatively long time scales. Other embodiments of the present invention are generally directed to methods of making such microparticles, methods of using such microparticles, microfluidic devices for making such microparticles, and the like.

Disclosed herein is a gelation device for gelling capsules. The gelation device includes a tubular column having a longitudinal axis extending along an axial direction of the tubular column a bottom portion and, a head portion. The bottom portion includes a first fluid inlet for introducing a dispersed phase into the tubular column and a second fluid inlet for introducing a continuous phase into the tubular column. The head portion includes a fluid outlet for removing gelled capsules from the tubular column and a stirring device being arranged inside the tubular column. The stirring device includes one or more stirring elements which each are longitudinally arranged inside the tubular column and which are each rotatable around the longitudinal axis of the tubular column and are configured to provide for a radial mixing of the dispersed phase and the continuous phase.

Nanoscale emulsions can be made by means of condensing a liquid vapor onto another liquid. The precise size, chemical composition, and density of emulsions may be controlled through varying the experimental parameters, such as surfactant concentration, time of condensation, humidity, and temperature.

This method comprises the following steps: (i) formation of drops of a first phase in a second phase substantially immiscible with the first phase; (ii) flow, in a flow line, of the drops; (iii) recovery of a dispersion comprising drops and second phase in a container; and (iv) injection of a solution into the flow line or at the outlet of the flow line, upstream of the container, the solution comprising at least one raw material which is not or is not very compatible with step (i) and/or step (ii).

Embodiments of the present application relate to compositions bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process with large particle diameter span.

The present invention generally relates to double emulsion droplet compositions, polymer particles that can be formed from such double emulsion droplet compositions, and to methods and apparatuses for making such compositions and particles. A double emulsion generally describes larger droplets that contain smaller droplets therein. These double emulsion droplet compositions can be used to create a variety of materials including polymer particles and polymeric shells and are further useful for encapsulating a variety of species including catalyst compounds and pharmaceutical agents. The double emulsion droplet compositions disclosed herein are readily formed using planar droplet (digital) microfluidic devices without channels, and either air or an immiscible liquid as an ambient medium.

Devices, systems, and their methods of use, for generating and collecting droplets are provided. The device includes a collection region comprising a side wall canted at an angle. The invention further provides multiplex devices that increase droplet formation.

Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.

Embodiments of the present application relate to compositions bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process with large particle diameter span.

Devices, systems, and their methods of use, for generating and collecting droplets are provided. The device includes a collection region comprising a side wall canted at an angle. The invention further provides multiplex devices that increase droplet formation.