Embodiments of the present application relate to commercial manufacturing processes for making bupivacaine multivesicular liposomes (MVLs) using independently operating dual tangential flow filtration modules.

The present invention addresses the problem of providing a water-in-oil emulsified composition having improved workability in a freezing range. This water-in-oil emulsified composition contains, as constituent fatty acids, 7-29 wt % of lauric acid and 7-19 wt % of palmitic acid, the weight ratio of stearic acid/lauric acid being 0.1-1.6, and has a hardness of 500-1500 gf at −18° C. The water-in-oil emulsified composition according to the present invention, when delivered or stored in a frozen state, can be directly and easily cut into pieces in any shape without requiring an operation such as thawing or temperature adjustment.

The present application discloses powder and aqueous formulations. These include but are not limited to water dispersible cannabinoid formulations, especially those comprising cannabidiol (CBD), cannabigerol (CBG), and cannabinol (CBN) as well as other cannabinoids. Generally, these embodiments do not include major amounts of Tetrahydrocannabinol (THC), but certain embodiments are envisioned that do contain measurable concentrations of THC. Embodiments may include one or more emulsifiers selected from the group consisting of Tween (polysorbate) 20, Tween 60, Tween 80, Span 20, Span 60, Span 80, Poloxamer 188, Vit E-TPGS (TPGS), TPGS-1000, TPGS-750-M, Solutol HS 15, PEG-40 hydrogenated castor oil, PEG-35 Castor oil, PEG-8-glyceryl capylate/caprate, PEG-32-glyceryl laurate, PEG-32-glyceryl palmitostearate, Polysorbate 85, polyglyceryl-6-dioleate, sorbitan monooleate, Capmul MCM, Maisine 35-1, glyceryl monooleate, glyceryl monolinoleate, PEG-6-glyceryl oleate, PEG-6-glyceryl linoleate, oleic acid, linoleic acid, propylene glycol monocaprylate, propylene glycol monolaurate, polyglyceryl-3 dioleate, polyglyceryl-3 diisostearate and lecithin.

The present invention relates to a process of producing a nano-Tan IIA microemulsion system comprising the following steps: (i) preparing a dispersed phase by dissolving Tan IIA in ethanol solvent in a ratio of mass of Tan IIA:volume of ethanol solvent of 8:10; (ii) preparing a carrier by heating liquid PEG (polyethylene glycol) to 60-80° C.; (iii) adding the carrier to the dispersed phase in a mass ratio of 40:60 with further heating of the dispersed phase to 40-60° C.; (iv) elmusifying by heating until the temperature reaches 100° C., adding ACRYSOL K-140 to the mixture of the carrier and dispersed phase obtained in step (iii) in a mass ratio of 40:60 with further stirring at 500-700 rpm at about 100° C. under vacuum; and (v) filtering the product by injection through a nanofilter system before filling-packing.

A method for continuously processing at least two liquid feed streams is provided. A system for continuously processing at least two liquid feed streams is also provided.

A fuel pump for a liquid fuel water injection system of a motor vehicle is provided. The fuel pump includes a low-pressure pump that mixes water from a water tank of the motor vehicle with liquid fuel from a fuel tank of the motor vehicle to a liquid fuel water emulsion and provides the liquid fuel water emulsion at a low pressure. A high-pressure pump is in fluid communication with the low-pressure pump and compresses the liquid fuel water emulsion from the low pressure to a high pressure for injecting the liquid fuel water emulsion into an internal combustion engine of the motor vehicle via an injection rail of the motor vehicle. A pump drive drives the low-pressure pump and the high-pressure pump synchronously with a pump frequency independently from an engine speed of the internal combustion engine of the motor vehicle.

The present invention relates to an apparatus for manufacturing cosmetic using instantaneous emulsification. Provided according to an aspect of the invention may be an apparatus for manufacturing cosmetic using instantaneous emulsification, which includes a housing which forms an outer appearance; an internal phase container which is replaceably coupled to the housing, and which stores internal phase fluid; an external phase container which is replaceably coupled to the housing, and which stores external phase fluid; a channel unit which generates emulsion by mixing the internal phase fluid provided from the internal phase container and the external phase fluid provided from the external phase container; and an operative unit which provides external force required to form and discharge emulsion at the channel unit by manipulation of a user.

Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.

Systems for generating stable emulsions may employ one or more liquid-liquid ejectors for mixing the oil with water through motive and suction streams to produce the emulsion as a discharge stream. One or more motive tanks may be fluidly coupled to the one or more liquid-liquid ejectors; the one or more motive tanks may supply the one or more liquid-liquid ejectors with a motive fluid. One or more suction tanks may be fluidly coupled to the one or more liquid-liquid ejectors; the one or more suction tanks may supply the one or more liquid-liquid ejectors with a suction fluid. One or more discharge tanks may be fluidly coupled to the one or more liquid-liquid ejectors; the one or more discharge tanks may collect an emulsion from the one or more liquid-liquid ejectors. Additionally, a flow line coupled to the one or more discharge tanks may feed the emulsions into a formation.

The invention comprises a method for generating a THC amended food product from a commercially available original food product, the method including the steps of: (1) receiving the original food product into a THC licensed manufacturing facility from a legal zone where THC in the original food product is illegal; (2) exposing THC, water, and an emulsifier to shear forces exceeding 50,000 sec.sup.−1 to generate a THC emulsion; and (3) adding, in the THC licensed manufacturing facility, the THC emulsion to the original food product to form a THC amended product.