An apparatus for supplying and dissipating heat, for carrying out reactions and for mixing and dispersing flowing media in a housing with an internal diameter for a medium and comprising internal fittings made up of a bundle of tubes with an external diameter or made up of other elongate elements oriented parallel to the longitudinal axis of the housing is provided. The apparatus includes crosspieces or crosspiece layers installed crosswise between the elongate elements. The crosspieces are inclined in relation to the longitudinal axis of the housing and are not in contact. After axially successive crosspieces, or a length, the crosspieces are installed between the tubes and turned by preferably 90°. A heat-transfer medium can flow in a co-current or counter-current mode. This results in a mixer/heat exchanger or reactor with an extremely large heat-transfer capacity and almost plug flow.

An apparatus for a dry gas scrubber includes: a cooling chamber defined by a housing having an inlet for receiving an effluent stream for treatment by the dry gas scrubber, an outlet for providing the effluent stream for treatment by the dry gas scrubber, and at least one cooling plate within the chamber, the cooling plate being thermally coupled with the housing and configured to deviate a direction of flow of the effluent stream when flowing from the inlet to the outlet. In this way, the cooling chamber is interposed between the process tool and the resin chamber of the dry gas scrubber and operates to cool the effluent stream prior to its being delivered to the resin chamber. Cooling the effluent stream in this way helps to improve the performance of the resin, even when the effluent stream is at an elevated temperature.

Systems and techniques are described for capturing target extracellular vesicles from a fluid sample. In some implementations, a microfluidic device includes a microfluidic channel where an internal surface of at least one wall of the microfluidic channel includes a plurality of grooves or ridges, or both grooves and ridges, arranged and configured to generate chaotic mixing within a fluid sample flowing through the microfluidic channel. The microfluidic device also includes a plurality of elongate flexible linker molecules, each having a molecular weight between about 1.8-4.8 kDa, where each elongate flexible linker molecule is bound at a first end to an internal surface of at least one wall of the microfluidic channel and is bound at a second end to one or more binding moieties that specifically bind to a target extracellular vesicle.

Systems and techniques are described for capturing target extracellular vesicles from a fluid sample. In some implementations, a microfluidic device includes a microfluidic channel where an internal surface of at least one wall of the microfluidic channel includes a plurality of grooves or ridges, or both grooves and ridges, arranged and configured to generate chaotic mixing within a fluid sample flowing through the microfluidic channel. The microfluidic device also includes a plurality of elongate flexible linker molecules, each having a molecular weight between about 1.8-4.8 kDa, where each elongate flexible linker molecule is bound at a first end to an internal surface of at least one wall of the microfluidic channel and is bound at a second end to one or more binding moieties that specifically bind to a target extracellular vesicle.

One or more embodiments relate to systems and methods for mixing of two or more fluids using a multi-chamber manifold. One or more embodiments relate to optimal mixing.

A decomposition chamber for an exhaust aftertreatment system includes an inlet conduit centered on an inlet conduit axis and configured to receive exhaust, a decomposition conduit coupled to the inlet conduit, an endcap coupled to the decomposition conduit, and an injector coupled to the endcap and configured to provide reductant into the decomposition conduit along an injection axis. The decomposition chamber includes a guide swirl mixer coupled to at least one of the inlet conduit or the endcap. The guide swirl mixer includes a first portion disposed within the inlet conduit, and a second portion disposed within the decomposition conduit such that the inlet conduit axis extends through the second portion. The second portion extends at least partially around the injection axis.

A decomposition chamber for an exhaust aftertreatment system includes an inlet conduit centered on an inlet conduit axis and configured to receive exhaust, a decomposition conduit coupled to the inlet conduit, an endcap coupled to the decomposition conduit, and an injector coupled to the endcap and configured to provide reductant into the decomposition conduit along an injection axis. The decomposition chamber includes a guide swirl mixer coupled to at least one of the inlet conduit or the endcap. The guide swirl mixer includes a first portion disposed within the inlet conduit, and a second portion disposed within the decomposition conduit such that the inlet conduit axis extends through the second portion. The second portion extends at least partially around the injection axis.

System and method for dispensing a flowable product are provided. The system includes a mixing chamber having a first inlet, a second inlet and an outlet. The mixing chamber of the system contains a mixing element capable of motion. The system also includes a paste located in an enclosure configured to flow into the mixing chamber via a first channel connected to the first inlet, and a flowable medium configured to flow into the mixing chamber via a second channel connected to the second inlet. The mixing chamber is configured to mix the paste and the flowable medium using the mixing element, thus, producing the flowable product that may be output via the outlet.

A static mixer is disclosed. The static mixer comprises a housing (22) defining an internal mixing cavity (36) that longitudinally extends along a central axis between an inlet (38) and an outlet (40) and is adapted for axial flow of a fluid therethrough. The static mixer also comprises a mixing element (42) disposed within the mixing cavity (36). The mixing element (42) is configured to be free from an impingement surface oriented substantially perpendicular to a main direction of fluid flow through the internal mixing cavity (36). The mixing element (42) comprises an elongated mixing blade that is oriented longitudinally within the mixing cavity (36) and comprises a nose axially oriented toward the inlet (38). The static mixer may comprise a heat-exchanging jacket integrally formed with the housing (22). An additive manufacturing system comprising the static mixer, and methods of making and using the same, are also disclosed.

A reversing flow apparatus comprising a chamber having a series of two or more sequential rings mounted on a shaft extending axially through the chamber, the rings being separated by a space, each ring comprising a circumference and one or more S-shaped members extending from a point in the circumference to another point in the circumference and across a center of the ring, the two or more sequential rings being mounted along the shaft in a twist arrangement such that at least one ring In the apparatus has its S-shaped member in a forward-facing position and at least one ring in the apparatus has its S-shaped member in a reverse-facing position.