The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (DVBM). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.

Included is a method and system of generating a diffused fluid using a spiral mixer comprising: injecting a first fluid into a first inlet port, generating a first fluid ribbon using a first narrow-gap slot; injecting a second fluid into a second inlet port and generating a second fluid ribbon; combining the first fluid and the second fluid ribbon into a spiraling flow around a cone feature in the mixing chamber of the first spiral mixing block, generating a combined flow of diffused fluids; dividing the combined flow in the mixing chamber of the first flow divider block, generating a divided flow of diffused fluids; combining the divided flow a mixing chamber of the final spiral mixing block, generating a final combined fluid flow in a spiraling flow around a final cone feature; and flowing the final combined fluid flow and dispensing the combined fluid flow onto a substrate.

An aftertreatment system includes an exhaust gas conduit, a mixer, and a mixing flange. The exhaust gas conduit includes an inner surface. The exhaust gas conduit has a conduit diameter d.sub.c. The mixer includes a mixer body and an upstream vane plate. The upstream vane plate has a plurality of upstream vanes. At least one of the plurality of upstream vanes is coupled to the mixer body. The mixing flange is disposed downstream of the mixer. The mixing flange includes a mixing flange opening having a mixing flange opening diameter d.sub.mf. 0.30*d.sub.cd.sub.mf0.95*d.sub.c.

An apparatus for dispersing particles in a fluid, comprising: a flow divider for receiving the fluid and for separating the fluid into a first fluid stream and a second fluid stream; first and second fluid branches for receiving the fluid streams; a branch joining section for receiving the fluid streams, the branch joining section having a collision zone for allowing the first and second fluid streams to collide; a first nozzle that is arranged in the first fluid branch; and a second nozzle is arranged in the second fluid branch, the first nozzle comprising an orifice that is followed by a fluid diverging section.

A power system including a selective reduction catalyst and an exhaust gas mixer positioned downstream thereof. The exhaust gas mixer includes an inlet opening a plurality of peripheral inlet openings and a plurality of swirler guides. The inlet opening is positioned to receive a first portion of exhaust gas exiting the SCR catalyst, while the plurality of peripheral inlet openings are positioned to receive a second portion of exhaust gas exiting the SCR catalyst. The swirler guides extend radially inwards from a respective peripheral inlet opening, so as to swirl the second portion of exhaust gas about and into the first portion of exhaust gas.

A reagent pre-loading system for a measuring device includes: a reagent admission arrangement arranged for receiving a reagent into the reagent pre-loading system; a sample admission arrangement arranged for receiving a sample fluid to be measured into the reagent pre-loading system, wherein the reagent admission arrangement and the sample admission arrangement are each arranged in selective fluid communication with a sample and reagent combination conduit for combining the sample fluid and the reagent; wherein the sample admission arrangement and the reagent admission arrangement are arranged to selectively: whilst the sample and reagent combination conduit is closed to fluid communication with the sample fluid at the sample admission arrangement, receive the reagent into the sample and reagent combination conduit so as to expel air from the sample and reagent combination conduit as the reagent is received therein and prime the sample and reagent combination conduit with the reagent.

Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (DVBM). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.

A static mixer device comprising a housing having a proximal end, a distal end, and an opening extending between the proximal and distal ends. In certain embodiments, a plurality of metal frits is positioned within the opening of the housing, each of the metal frits extending across a cross-sectional dimension of the opening and having interconnected porosity. In other embodiments, one or more mixer elements fabricated using laser additive manufacturing technology and having novel configurations are positioned within the opening of the housing. In yet other embodiments, the housing comprises multiple openings having different diameters from each other, with each opening either extending through the housing with a constant diameter or with one or more of the openings having a varying diameter.

A mixer assembly comprises a tubular housing including an exhaust gas inlet, an exhaust gas outlet, and a reductant inlet on a side of the tubular housing. An upstream mixing element is positioned within the tubular housing upstream from the reductant inlet. A downstream mixing element is positioned within the tubular housing downstream from the reductant inlet and the upstream mixing element. The upstream and downstream mixing elements at least partially define a reductant receiving mixing chamber in which the injected reductant and exhaust gas mix. A divider is positioned within the tubular housing downstream from the upstream mixing element to split the exhaust into two divided flow streams prior to exiting through the exhaust gas outlet.