Fume extract extracted by a fume-dissolution harvesting and accumulation system for accumulating in a tincture featuring at least one sonic cavitation device configured to exert cavitation effect in a solvent-fume mix, and a fume generating compartment for burning and/or vaporizing fume-releasing source-material configured to produce a portion of the fume at burning temperatures, and another portion at evaporation temperatures. Corresponding method is provided.

Microfluidic devices for use with reagents bound to microspheres for determination of the concentration of an analyte in a liquid sample are provided. The devices include two sequential mixing channels that promote rapid binding of microsphere-bound reagents with reagents in solution and a means for detecting labeled microsphere-bound reaction products. Also provided are methods for using the devices with microsphere-bound reagents to determine the concentration of an analyte in a liquid sample and to measure the binding affinity of antibody for an antigen.

The present invention relates to a fluid mixer having a fluid inlet (5), a first passage (1) which connects to the fluid inlet, a helical flow passage (2) which connects to the first flow passage, branched flow passages (4) which are branched from the helical flow passage, a second flow passage (3) to which the branched flow passages individually connect, a connection flow passage (7) which connects the first flow passage and the second flow passage, and a fluid outlet (6) which connects to the second flow passage. The branched flow passages are individually branched from different positions in the direction of flow through the helical flow passages. The branched flow passages which are branched from the helical flow passage individually connect to the second flow passage at different positions in the direction of flow through the second flow passage.

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reaction between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control. The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalized into the microcapsules.

A method includes, under control of control circuitry implementing a mixing protocol, aspirating reagents from multiple different reagent reservoirs into a cache channel. Designated amounts of the reagents are automatically aspirated from the corresponding reagent reservoirs by corresponding sippers based on the mixing protocol implemented by the control circuitry. The method also includes discharging the reagents from the cache channel into a mixing reservoir, and mixing the reagents within the mixing reservoir to form a reagent mixture.

Material flow amplifiers overcome drawbacks associated with known adverse flow conditions (e.g., surface erosion and head losses) that arise from flow of certain types of materials (e.g., fluids, slurries, particulates, flowable aggregate, and the like) through a material flow conduit. Such material flow amplifiers provide for flow of flowable material within a flow passage of a material flow conduit (e.g., a portion of a pipeline, tubing or the like) to have a cyclonic flow (i.e., vortex or swirling) profile. Advantageously, the cyclonic flow profile centralizes flow toward the central portion of the flow passage, thereby reducing magnitude of laminar flow. Such cyclonic flow profile provides a variety of other advantages as compared to a parabolic flow profile (e.g., increased flow rate, reduce inner pipeline wear, more uniform inner pipe wear, reduction in energy consumption, reduced or eliminated slugging and the like).

Disclosed cyclonic flow-inducing pumps overcome drawbacks associated with known adverse flow conditions that arise from flow of certain types of materials through a material flow conduit. Such cyclonic flow-inducing pumps provide for flow of flowable material within a flow passage of a material flow conduit (e.g., a portion of a pipeline, tubing or the like) to have a cyclonic flow (i.e., vortex or swirling) profile. Advantageously, the cyclonic flow profile centralizes flow toward the central portion of the flow passage, thereby reducing magnitude of laminar flow. Such cyclonic flow profile provides a variety of other advantages as compared to a parabolic flow profile such as, for example, increased flow rate, reduce inner pipeline wear, more uniform inner pipe wear, reduction in energy consumption, reduced or eliminated adverse considerations such as slugging.

Phosgene is mixed with an organic polyamine to produce polyisocyanate compounds. A phosgene flow is established in a conduit (15), and the organic polyamine is injected into the phosgene flow. A constricted region (4) of the conduit (15) resides downstream of the point of the polyamine injection. The presence of the constricted region (4) reduces by-product formation.

Disclosed herein is a microfluidic mixer comprising first and second input chambers, first and second flow paths, and an output chamber. According to embodiments of the present disclosure, the first input chamber and the output chamber respectively have their bottom surfaces leveled with that of the first and/or second flow paths, while the second input chamber has its bottom surface protruded below that of the first flow path. Also disclosed herein is a microfluidic system comprising the present microfluidic mixer, and a pump for introducing a first and a second fluid reactants respectively into the first and a second input chambers.