Novel activators of the APC complex and methods and uses of these activators are provided. In particular, the activators are used for increasing resistance to stress and/or increasing lifespan in a plant or mammalian cell, in a plant or mammalian embryo or in a plant or subject. The activators are also used for treating cancer in a subject.

Novel activators of the APC complex and methods and uses of these activators are provided. In particular, the activators are used for increasing resistance to stress and/or increasing lifespan in a plant or mammalian cell, in a plant or mammalian embryo or in a plant or subject. The activators are also used for treating cancer in a subject.

The present invention provides a method of treating a locus against pest infestation using a compound of Formula I as described herein or an agriculturally acceptable salt thereof. The present invention also provides combinations and compositions comprising the compound of Formula I or an agriculturally acceptable salt thereof and uses thereof. The present invention also provides methods of extracting the compound of Formula I from a fungus.

The present invention provides a method of treating a locus against pest infestation using a compound of Formula I as described herein or an agriculturally acceptable salt thereof. The present invention also provides combinations and compositions comprising the compound of Formula I or an agriculturally acceptable salt thereof and uses thereof. The present invention also provides methods of extracting the compound of Formula I from a fungus.

The invention provides materials and method for controlling pests, in particular, nematodes. The invention also provides compositions comprising biosurfactants as pesticides.

The invention provides materials and method for controlling pests, in particular, nematodes. The invention also provides compositions comprising biosurfactants as pesticides.

The present invention relates in general to the use of a kit or composition comprising at least one yeast and at least one bacterium, selected from the group consisting of lactobacillales, rhizobiales and bifidobacteriales, and/or comprising calcium for improving plant health, for improving plant resistance to plant pathogens, for preventing or reducing mycotoxin contamination of plant material, for improving plant resistance to a plant disease, for preventing perithecia formation of a plant pathogen on plant debris, for plant protection and/or as plant stimulant. The present invention also relates to corresponding compositions and kits and a method of applying such composition or kit to a living plant or plant debris.

The present invention relates in general to the use of a kit or composition comprising at least one yeast and at least one bacterium, selected from the group consisting of lactobacillales, rhizobiales and bifidobacteriales, and/or comprising calcium for improving plant health, for improving plant resistance to plant pathogens, for preventing or reducing mycotoxin contamination of plant material, for improving plant resistance to a plant disease, for preventing perithecia formation of a plant pathogen on plant debris, for plant protection and/or as plant stimulant. The present invention also relates to corresponding compositions and kits and a method of applying such composition or kit to a living plant or plant debris.

Methods for producing heterologous proteins are disclosed. In particular, the present disclosure provides improved methods of producing desired proteins, including multi-subunit proteins such as antibodies, with a higher yield and improved purity. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.

The present disclosure discloses a Pichia kudriavzevii and a multifunctional complex microbial inoculant and use thereof, and belongs to the technical field of bioengineering. The Pichia kudriavzevii of the present disclosure has a degrading ability of lactic acid as high as 12.69 g.Math.L.sup.−1, which is 2.04 times that of a type strain. At the same time, the strain can also metabolize ethanol and has an OD.sub.600 of 4.48 after fermentation in a sorghum juice medium at 30° C. and 200 rpm for 3 d. The Pichia kudriavzevii could completely consume 58 g.Math.L.sup.−1 of glucose in the sorghum juice medium after 60 h of fermentation and produce 13.06 g.Math.L.sup.−1 of ethanol. The Pichia kudriavzevii degrades lactic acid and can relieve a lactic acid pressure of a fermentation system and enable Saccharomyces cerevisiae to grow and metabolize to produce wine. In addition, the strain and the microbial inoculant thereof can inhibit the production of filamentous fungi and geosmin and have important use prospects for maintaining homeostasis of a fermentation system and food preservation.