A mixing segment for a static mixer includes inlets and outlets connected by a passage to deflect respective part flows of a material from the inlet to the outlet. Each of the outlets arranged such that an extent thereof is rotated by an angle of rotation of at least 45. A first extent of the passages gradually reduces between an inlet and a constriction of the passage, and a second extent of the passage gradually increases between the constriction and the outlet. The reduction in size of the first extent or the increase in size of the second extent is formed by two walls of the passage that are inclined with respect to one another and with respect to the longitudinal axis of the mixing segment, with at least a part of the walls inclined with respect to the longitudinal axis formed by a curved part surface.

A mixer includes a mixer housing, a mixing element and a mixer inlet section having at least two inlets at an input side and at least two outlets at an output side. The outlets are in fluid communication with the mixing element. The inlets are sealingly connected to corresponding exit openings of a cartridge. The mixer housing includes a connection device for connecting the mixer to the cartridge by rotational movement around a longitudinal axis. An engagement element is disposed at an outer surface of the mixer housing which is accessible from the outside when the mixer is connected to the cartridge. The engagement element includes an engagement surface spaced apart from the upstream end of the mixer housing in the direction of the longitudinal axis. The engagement surface points in the direction of the upstream end of the mixer housing thereby forming an undercut.

A syringe system for harvesting, mixing and emulsifying lipoaspirate and for further harvesting stromal vascular faction of adipose tissue. Stromal vascular faction contains mesenchymal stem cells, which have medically therapeutic uses. A mixing and/or emulsifying apparatus can be reciprocated in a syringe and combined with the stopper of the syringe, so that the syringe can be multi-purpose for harvesting, mixing, emulsifying, centrifuging, and transferring. This system minimizes transfers between syringes, allowing the system to remain closed and sterile.

One aspect relates to a device for producing a bone cement paste from a monomer liquid and a cement powder and for delivering the bone cement paste, the device having a cartridge with a cylindrical interior, the interior of the cartridge being closed at the front side apart from a delivery opening for discharging the bone cement paste from the interior. A delivery plunger is arranged in the interior of the cartridge and mounted so as to be pushable in the direction of the delivery opening. The cement powder is arranged in the interior of the cartridge between the delivery opening and the delivery plunger. A closure closes the delivery opening and is mounted so as to be movable relative to the delivery opening. A line element is arranged at the front side of the delivery opening and includes a closure receptacle for receiving at least part of the closure. The closure is pushable into the closure receptacle by pressure on the bone cement paste such that the delivery opening is opened, when the closure has been pushed into the closure receptacle, the line element provides a free line cross-section through which the bone cement paste is pushable out through the delivery opening and out of the device.

A device for mixing a bone material with a liquid is provided. The device comprises a chamber having a proximal end and a distal end, and the bone material disposed within the chamber, the bone material comprising a coherent mass of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with liquid from the distal end of the chamber, when the plunger is in an extended position.

Disclosed are a sample pretreatment module and a sample pretreatment method using the same. The sample pretreatment module including: a body having a chamber for accommodating a sample therein; a cap coupled to one end of the body; a dotting substrate provided to have at least some portion of it dotted with the reagent and be inserted into the chamber; a discharge tip movably coupled to the other end of the body for discharging a sample accommodated in the chamber; a permanent magnet provided to be inserted in the chamber and mix the sample by rotating owing to a magnetic force acting in accordance with a change in a magnetic field externally applied; and a moving unit movably provided in the cap and pressing the sample in the chamber according to the movement to discharge the sample to the outside.

A device for mixing and dispensing bone material is provided. The device comprises a tubular member having an interior surface configured to receive bone material and a fluid to mix the bone material disposed within the tubular member. The tubular member is flexible and has a proximal opening configured to slidably receive a plunger, and a distal opening configured to dispense a mixed bone material from the interior surface of the tubular member. The plunger is less flexible than the tubular member. Methods of mixing and dispensing bone material are also provided.

A mixing device, in particular for bone cement, in which at least two ampoules provided with a septum are pushed onto needles, in parallel to each other, for discharging the liquid.

Provided are methods and devices for dissolving solid protein compositions, such as solid compositions comprising fibrinogen, in an aqueous solvent. The methods comprise use of a closed container containing a volume of solid fibrinogen composition and a head space wherein the pressure within the headspace is sub-atmospheric. Aqueous solvent is introduced into the container while maintain the sub-atmospheric pressure, and subsequent to addition of the solvent, the size of the headspace is decreased to bring the pressure to atmospheric pressure. The devices are suitable for use in the disclosed method.

One aspect relates to a bone cement applicator having a cartridge with an interior, a cartridge head with a delivery opening, a mixing member which is movable in the interior with a mixing rod. A delivery plunger is arranged in the cartridge and is mounted in the interior and is pressable in the direction of the delivery opening. The delivery plunger rests with an outer cylindrical circumferential surface against an inner wall of the cartridge. A clamping element is arranged on the inner wall of the cartridge in the region of a back side of the interior. The clamping element projects out of the inner wall of the cartridge. The cylindrical circumferential surface of the delivery plunger is resiliently deformable by the clamping element in the direction of a central cylinder axis, such that the delivery plunger is clampable in place with the at least one clamping element on the back side of the cartridge.