A dynamic mixer for mixing a multi-component material includes a mixing rotor capable of being rotated about an axis of rotation, the mixing rotor having a coupling socket configured at an end thereof. The coupling socket has a reception space configured to receive at least a part of a polygonal shaped coupling plug of a drive shaft to transfer torque from the drive shaft to the mixing rotor. The reception space has an inner length in the direction of the axis of rotation and has an inner surface extending over the inner length and surrounding the axis of rotation.

A static mixer 10 for mixing a fluid flow having at least two components is disclosed, as well as a method for mixing first and second components with the static mixer 10. The static mixer 10 includes a mixing conduit 20 having a first inner surface 38a, a second inner surface 38b that extends from the first inner surface 38a, and a third inner surface 38c that extends from the first inner surface 38a to the second inner surface 38b. The first, second, and third inner surfaces 38a, 38b, 38c define a mixing passage receiving the fluid flow. The first and second inner surfaces 38a, 38b are offset by a first acute angle, the first and third surfaces 38a, 38c are offset by a second acute angle, and the second and third surfaces 38b, 38c are offset by a third acute angle. The static mixer 10 includes a mixing element 100 positioned in the mixing passage.

Mixing device (1) and fluid mixing method, by means of successive transfers between syringes. The mixing method comprises placing a pair of syringes (2, 3) in the mixing device (1), adjusting a variable fixing element adaptable to the pair of syringes (2, 3) and selecting and running a mixing programme, being the mixing force, the speed and the range and the number of transfers adjustable. The mixing device comprises a mobile carriage (7) longitudinally movable and fixing elements (8, 9) with an adjustable distance between them. The invention allows for the mixing or emulsifying of blood fluids with different viscosity, particularly a protein gel and a platelet-rich plasma, for the preparation of dermatological formulations, in a versatile, hygienic and effective manner.

An infusion system for sonothrombolysis treatment uses a syringe loaded with a microbubble solution and operated by a syringe pump to deliver the microbubble solution to a subject during sonothrombolysis treatment. To prevent the stratification of the microbubble solution in the barrel of the syringe during treatment, the barrel also contains a plurality of magnetic beads which are agitated into semi-random patterns of motion in the syringe chamber during the procedure. The magnetic beads are moved by magnetic attraction and repulsion from the moving magnets of a magnetic stirrer mounted in proximity to the syringe during treatment.

Delivery systems for in situ forming foam formulations are provided. The devices may include various actuation mechanisms and may entrain air into fluid formulation components in a variety of ways, including mixing with air and the addition of compressed gas.

One aspect relates to a device for the production of a bone cement dough from a monomer liquid and a cement powder comprising a cartridge with an internal space; a cartridge head with a dispensing opening; a conveying plunger that is supported in the internal space of the cartridge such that it is pushable in the direction of the dispensing opening; a dispensing plunger between the dispensing opening and the conveying plunger that is supported in the internal space of the cartridge such that it is pushable in the direction of the dispensing opening; a first hollow space, in which the cement powder is arranged; a second hollow space that is bordered by the dispensing plunger and the conveying plunger; a rear-side part of the internal space of the cartridge; and a conducting means that connects the second hollow space to the rear-side part of the internal space of the cartridge such as to bypass the conveying plunger and be permeable to the monomer liquid. The conducting means can be closed by the conveying plunger with respect to the second hollow space by shifting the conveying plunger in the direction of the dispensing plunger, and a feedthrough in the dispensing plunger that connects the first hollow space and the second hollow space such as to be permeable to the monomer liquid.

One embodiment relates to a device for the production of a bone cement dough from a monomer liquid and a cement powder comprising a cartridge with an internal space; a cartridge head with a dispensing opening; a conveying plunger that is arranged in the internal space of the cartridge and is supported in the internal space of the cartridge such that it is pushable in the direction of the dispensing opening; a dispensing plunger between the dispensing opening and the conveying plunger that is supported in the internal space of the cartridge such that it is pushable in the direction of the dispensing opening; a first hollow space, in which the cement powder is arranged; a second hollow space that is bordered by the dispensing plunger and the conveying plunger; a fluid opening that is arranged in the conveying plunger; a feedthrough that connects the first hollow space and the second hollow space to each other, and a closure means that is arranged on a rear side of the dispensing plunger. The closure means projects away from the dispensing plunger and is situated at a distance from the fluid opening. The fluid opening is closable with the closure means. The closure means is mobile in the closed fluid opening such that the fluid opening stays closed, while the conveying plunger is pushable further in the direction of the dispensing plunger.

A reagent preparation assembly includes a body and a reaction chamber adjacent the body, the reaction chamber includes a reagent therein, such as a lyophilized reagent. An access port extends into the reaction chamber, and the access port is configured to receive an instrument. A seal extends across a portion of the reaction chamber and the access port. A reconstitution assembly is movably coupled with the body. The reconstitution assembly includes a plunger, a syringe and a piston. The plunger is movably coupled with the body. The syringe is selectively engaged with the plunger. The syringe includes a solution reservoir containing a solution, and movement of the syringe pierces the seal. The piston is selectively engaged with the plunger, and the piston is movably coupled within the syringe. Movement of the piston pushes the solution into the reaction chamber.

A device for storing first and second ingredient materials, mixing the ingredient materials to form an adhesive material and dispensing the adhesive material. The device comprises: a nozzle for dispensing the third material; a first container adapted to store a first ingredient material and mix the first ingredient material with a second ingredient material; a second container disposed within the first container, and moveable between a storage position in which a second ingredient material is stored in the second container and a mixing position in which the second ingredient material is moved to the first container; a mixer that longitudinally extends into the first and second containers; a handle alternatively coupled to the mixer to mix the first and second ingredient materials or to the second container to move the second container to a dispensing position to dispense the third material. During use, the first container is rotated causing the second container to move relative to the first container and the second material to flow into the first container for mixing. After mixing, the handle is uncoupled from the mixer and coupled to the second container to dispense the third material from the nozzle. Embodiments are also described herein for a method of making the device and a method of using the device.

A device for mixing a bone material with a liquid is provided. The device comprises a chamber having a proximal end and a distal end, and the bone material disposed within the chamber, the bone material comprising a coherent mass of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with liquid from the distal end of the chamber, when the plunger is in an extended position.