Device for the mixing of polymethylmethacrylate bone cement and for storing a monomer liquid and a cement powder as starting components of the bone cement, comprising a cartridge having an internal space closed on one side by a mobile dispensing plunger; a monomer container for a monomer liquid and/or a connector for attachment of a monomer container which can be opened in the device so that the monomer liquid flows from the monomer container into the device; and a connecting conduit through which the monomer liquid can be guided into the internal space of the cartridge; having a pumping plunger that can be shifted axially in the hollow cylinder arranged in the hollow cylinder, which can be used to push monomer liquid from the hollow cylinder through the connecting conduit into the internal space of the cartridge by actuating the pumping plunger.

A metering and mixing device contains a multichamber cartridge and a cartridge holder having a reception container for the multichamber cartridge and a compressed air connection and a connection for an application device. The reception container has an internal tube arranged coaxially to the walls of the cartridge holder and equipped with static mixing elements. The multichamber cartridge contains an upper portion having a directional valve, a middle portion configured as a tubular empty space surrounded by at least two chambers arranged tubularly in the direction of the longitudinal axis of the cartridge, and a lower portion having a piston for each chamber. The multichamber cartridge is arranged in the cartridge holder such that the inner wall of the inner tube of the multichamber cartridge bears, leak-tight, against the outer wall of the tube of the cartridge holder.

A system for use in combining two part preparations, such as bone cement, can include a chamber for intermixing liquid and powder components, a container, a vacuum channel, and a filter. The mixing chamber can be configured to hold a non-liquid, polymer powder component of a bone cement. The container can be configured to hold a liquid component of the bone cement. The vacuum channel can direct a partial vacuum to draw the liquid component from the container into the non-liquid component in the mixing chamber to intermix the components and to thereby provide a settable bone cement.

A fluid path set includes a first fluid line having a proximal end fluidly connectable to a source of a first fluid and a second fluid line having a proximal end fluidly connectable to a source of a second fluid. A flow mixing device is in fluid communication with distal ends of the first and second fluid lines. The flow mixing device includes a housing, a first fluid port provided for receiving the first fluid, and a second fluid port for receiving the second fluid. A mixing chamber is disposed within the housing and is in fluid communication with the first and second fluid ports. A third fluid port in fluid communication with the mixing chamber for discharging a mixed solution of the first and second fluids. A turbulent flow inducing member is disposed within the mixing chamber for promoting turbulent mixing of the first and second fluids.

The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.

A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.

An apparatus and system for preparing a hair coloring includes as graduated syringe and a container filled with a pigmented hair dye. The container includes an air-tight chamber and an opening, and also includes an engagement mechanism for installing the container on a rack for support. An air-tight reclosing seal at the opening allows the syringe to engage the air-tight reclosing seal, and extract the hair dye from the air-tight chamber. When the syringe is disengaged from the container, the air-tight reclosing seal closes off the air-tight chamber and permitting a known quantity of the hair dye to be withdrawn from the container into the syringe, allowing an accurate and repeatable quantity of hair dye to be dispensed from the container.

An infusion system for sonothrombolysis treatment uses a syringe loaded with a microbubble solution and operated by a syringe pump to deliver the microbubble solution to a subject during sonothrombolysis treatment. To prevent the stratification of the microbubble solution in the barrel of the syringe during treatment, the barrel also contains a plurality of magnetic beads which are agitated into semi-random patterns of motion in the syringe chamber during the procedure. The magnetic beads are moved by magnetic attraction and repulsion from the moving magnets of a magnetic stirrer mounted in proximity to the syringe during treatment.

A device and/or method stores, mixes, and applies polymethylmethacrylate bone cement, wherein the device and/or method comprising a first container for a first pasty component, a dispensing plunger that is arranged such that it can be shifted in the first container and serves for extruding the content of the first container through a dispensing tube opposite from the dispensing plunger. The dispensing tube can be rotated and shifted in longitudinal direction through a feed-through in a side of the first container opposite from the dispensing plunger. A mixing facility is arranged in the first container, is secured to the dispensing tube, and is movable in the first container by moving the dispensing tube. At least one second container for at least one second component is arranged on the first container, whereby the internal space of the at least one second container is closed with respect to the internal space of the first container by means of a closure, which is openable. The at least one second container is limited, on the side opposite from the closure, by a dosing plunger, and whereby at least one limiting surface of the first container is formed by a mobile volume compensation element.

A device for mixing bone cement material, the device comprising a mixing body having a chamber, and wherein the mixing body has an open end; a lid arranged to be fitted to the open end; means for mixing bone cement material in the chamber, the means for mixing comprising a rod extending through the lid and into the chamber, wherein the rod has a frangible portion; said lid comprising a cap moveable to a first position covering the frangible portion of the rod, and to a second position revealing the frangible portion.