A system for dispensing a biocompatible reactive formulation includes a first chamber containing a first fluid having a first reactive component, a second chamber containing a second fluid having a second reactive component, and a third chamber containing a third fluid. A spray tip assembly is configured for spraying a final mixture of the first, second and third fluids. The spray tip assembly has a spray tip housing, a mixing element disposed within the spray tip housing, a mixing chamber located between the mixing element and an inner surface of the spray tip housing. The mixing element has a proximal end adjacent the proximal end of the spray tip housing and a distal end adjacent the distal end of the spray tip housing, a third fluid inlet opening at the proximal end of the mixing element, and one or more third fluid exit openings formed in the outer surface of the mixing element that are in fluid communication with the third fluid inlet opening and that extend laterally to the outer surface of the mixing element for being in fluid communication with the mixing chamber. A fluid connector is secured to the proximal end of the spray tip housing and opposes the proximal end of the mixing element. The fluid connector has first and second fluid channels in fluid communication with the mixing chamber, and a third fluid channel in fluid communication with the third fluid inlet opening of the mixing element. A pump assembly is coupled with the first, second and third chambers for simultaneously forcing the first, second and third fluids to flow through the first, second and third fluid channels of the fluid connector and into the proximal end of the spray tip housing.

To provide an emulsion preparation device capable of forming an emulsion in a chemical liquid of diverse composition and further realizing a relatively low sliding resistance. An emulsion preparation device (1) provided with a filter part (10), wherein: the filter part (10) is constructed from first and second, two mesh parts (31) and (33) and fibers (32); and the fibers (32) are loaded into a space (30) between the first mesh part (31) and the second mesh part (32).

A system for delivering to a patient a slurry which includes a fluid and a material that is non-dissolvable or immiscible in the fluid. The system includes a container adapted to contain the slurry and a supernate of the slurry, a syringe adapted to contain the slurry after dilation with the supermate, a fluid path between the syringe and the contents of the container, the fluid path including a needle at least partially disposed within the contents of the container, a plunger disposed in the syringe and adapted to create pressure in the syringe to cause a dilated slurry to flow into the syringe through the fluid path, and a fluidizing systen associated with the container and comprising a holder adapted to move the needle within the container to affect dilation of the slurry with a portion of the supernate.

A clotting serum production device including a main chamber, an inlet housing, and an outlet port. The main chamber is defined by a first end wall, a second end wall opposite to the first end wall, and a side wall extending between the first end wall and the second end wall. The inlet housing extends from the first end wall. The inlet housing includes a first inlet port, a second inlet port, and a first conduit extending between the first inlet port and a second conduit. The second conduit extends between the second inlet port and the main chamber. The inlet housing is configured to provide one-way fluid flow from the first inlet port to the second inlet port and to provide one-way fluid flow from the second inlet port to the main chamber. An outlet port is in fluid communication with the main chamber and provides fluid communication with an exterior of the clotting serum production device.

Storage and mixing systems for pasty two-component polymethyl methacrylate bone cements comprise a tubular cartridge having a cylindrical inner chamber, a cartridge head, which closes one end of the tubular cartridge at the front side, a partition that is disposed axially in the cylindrical inner chamber of the cartridge. The partition divides the cylindrical inner chamber of the cartridge bounded by the cartridge head into two cavities that are spatially separated from one another, wherein a first pasty cement component is present in the first cavity and a second pasty cement component is present in the separate second cavity. The systems further comprising two dispensing plungers axially displaceable in the two cavities of the cartridge, wherein the dispensing plungers close the two cavities on the back side of the cavities situated opposite the cartridge head, a bending device for deforming the partition, wherein the bending device is axially movable in the cartridge and is disposed, or is to be disposed, behind the dispensing plungers, as seen from the cartridge head, wherein the bending device has a deflection surface that is inclined with respect to the axis of the cartridge and pushes the partition laterally in the direction of the inside wall of the cartridge when the bending device is pushed into the cartridge.

Methods of concentrating beads in a droplet and/or loading beads on a fluidic device are provided, including among other things, a method of concentrating beads in a droplet, the method comprising: (a) providing a droplet actuator comprising: (i) an interior droplet operations volume; and (ii) a reservoir exterior to the interior volume; (iii) a droplet established in a liquid path extending from the reservoir into the interior volume; (b) providing magnetically responsive beads in the portion of the droplet which is in the reservoir; (c) magnetically attracting the magnetically responsive beads through the liquid path into the portion of the droplet which is in the interior volume; and (d) forming a droplet comprising one or more of the magnetically responsive beads in the interior volume.

A storage and mixing system for pasty two-component polymethyl methacrylate bone cements comprises a tubular cartridge with a cylindrical interior, a cartridge head that closes one end of the tubular cartridge, a partition wall axially disposed in the cylindrical interior and dividing the cylindrical interior into two spatially separate cavities, the first cavity including a first pasty cement component and the second cavity including a second pasty cement component, two delivery plungers disposed movably in the two cavities and connected via a connecting means, wherein a wedge or cone having a cutting edge on the front side thereof facing the cartridge head is disposed on the connecting means, such that said cutting edge cuts open the partition wall when the delivery pistons are advanced towards the cartridge head and the wedge or cone presses the cut open parts of the partition wall towards the inner wall of the cartridge.

A stable-foam inhalation-device cartridge for a stable-foam inhalation device which dispenses a stable foam to be consumed by a user. The cartridge is devoid of an electrical energisation component. The cartridge includes a flexible mixing chamber, first and second foam-generation elements, an expansion chamber, a partitioning element having one or more mixing members for agitating a consumable foam and a discharge element. The discharge element has an outlet opening an inlet opening and a discharge conduit which interconnects the inlet opening with the outlet opening. The discharge conduit has a longitudinal extent which locates the inlet opening at a position closer to the partitioning element than to the outlet opening.

A combination plunger, a mixing device and a mixing syringe including the same are provided. The mixing syringe includes concentric outer and inner barrels that form an outer chamber, the inner barrel having an inner chamber. The combination plunger includes a mixing plunger and a delivery plunger and a biasing means. The mixing plunger is slidably located in the outer chamber and translated by coordinated depression of the delivery plunger to transfer a first substance from the outer chamber to mix with a second substance in the inner chamber. After the mixing stage is complete, the delivery plunger is disengaged from the mixing plunger and permitted, such as by rotation, to be further depressed in the axial direction to deliver fluid contents of the mixing syringe to a recipient. The mixing syringe needle is then retracted as result of engagement by the delivery plunger and activation of the biasing means.

A method for controlling fluid ratio accuracy during a dual flow injection with a powered injection system is described. The method includes predicting a first capacitance volume of a first syringe comprising a first medical fluid and a second capacitance volume of a second syringe comprising a second medical fluid with a first capacitance correction factor and a second capacitance correction factor, respectively, selecting a ratio of the first medical fluid and the second medical fluid to be administered to a patient in the dual flow injection, determining a relative acceleration ratio of a first piston of the first syringe and a second piston of a second syringe based on the predicted first capacitance volume and the predicted second capacitance volume, wherein the relative acceleration ratio is selected to maintain the selected ratio of the first medical fluid and the second medical fluid during the dual flow injection, and injecting a mixture of a first medical fluid and a second medical fluid having the selected ratio with the powered injection system.