Provided herein are gas mixing systems, comprising a gas inlet for receiving two or more gases and a mixing chamber with a static mixer for mixing the gases. Preferred mixing chambers further comprise a reduced pressure compartment downstream of the static mixer that is in fluid communication with the gas inlet. A gas outlet is in fluid communication with the mixing chamber, and one or more sensors are coupled to the reduced pressure compartment and are configured to continuously sense various parameters such as barometric pressure and the percentage of oxygen in the gas mixture moving through the mixing device. Most typically, the readings of the sensor are pre-compensated for temperature, pressure, and humidity. Also provided herein are methods for using the same.

A method and device for mixing plastic from liquid components in a mixer (8) and conveying it through a line (10) into a mould (12), in particular for vacuum infusion, characterised in that the components are each pumped by means of a pump (24) from their own respective component container (22) into a mixer (8) and are mixed therein, that these volume flows are controlled by a controller (26) in such a manner that they supply the components to the mixer (8) in a specific ratio, that the pressure loss in the line (10), between a pressure sensor in one of the component supply lines (32) leading to the mixer (8) and the mould (12), is determined, and that the pressure is measured by the pressure sensor and supplied to a controller (26) which, taking into consideration the determined pressure loss, controls the volume flows such that the pumps (24) supply the components to the mixer (8) at a pressure that is greater than the ambient pressure or than another specific pressure that should not be exceeded in the mould (12) by at most the pressure loss.

There is provided an inline saturator system and method for gas exchange with an aqueous-phase liquid. The system includes a pressure vessel, configured to receive a first liquid and a first gas from external sources and to discharge a second liquid and a second gas from the pressure vessel, and a gas infusion device situated within the pressure vessel. The gas infusion device is configured to receive the first liquid and first gas, to facilitate gas exchange therebetween, producing the second liquid and the second gas, and to discharge the second liquid and second gas into the pressure vessel. The system further includes a recirculation system configured to direct a portion of liquid within the pressure vessel back into the saturator device, where injection of the redirected liquid into the gas infusion device forces the first liquid into the gas infusion device for the gas exchange.

An exemplary process air recirculation system, and an electric heater mixing apparatus is disclosed herein. Exemplary process air recirculation systems comprise the electric heating mixing apparatus. An exemplary electric heating mixing apparatus comprises: walls defining a first chamber having a first upstream opening and a first downstream opening, and a second chamber having a first upstream opening and a first downstream opening, wherein the second chamber is adjacently disposed to the first chamber, a first inlet damper disposed at the first upstream opening, a second inlet damper disposed at the second upstream opening, and a resistance-type electric air heater disposed in the first chamber.

A dispersion device includes a stirring and mixing unit that mixes a powder with a liquid, a powder feed unit that feeds the powder to the stirring and mixing unit, and a dry gas generation unit that supplies a dry gas to the powder feed unit. The powder feed unit is sealable.

A small-scale, batch-wise device to simulate high-shear, short-duration emulsification of fluids from various industrial processes at elevated temperatures and pressures for the purpose of determining the quality and stability of those emulsions under different conditions and with different additives. A threaded, transparent tube capable high temperature and pressure is fitted with a threaded bearing with a shaft sealed gas tight at two points with spring-loaded, internally-facing, open rings. A socket head on the external end of the shaft held on a high-speed motor-drive rotates mixing blades on the internal end of the shaft. Process fluids and additives are added to the tube with a vaporizing liquid. The tube is sealed, heated to the process temperature under pressure, then inverted onto the motor drive, by which the blades are rotated at high-speed for a short duration. The tube is righted and the emulsion observed over time at process temperature under pressure.

A safety device for a single-use mixing or storage system (10), especially for use in a biopharmaceutical process, includes a flexible bag (12) made from a film material and a support structure (14) receiving and supporting the bag (12) in several directions. The support structure (14) allows an expansion of the bag (12) in an expansion direction. The safety device further includes a detection unit (20) adapted to detect an expansion of the bag (12) in the expansion direction, and a control unit (28) connected to the detection unit (20) and adapted to initiate a safety measure in response to the expansion of the bag (12) in the expansion direction exceeds a given threshold.

A method for the preparation of pharmaceutical products is provided that utilizes a machine having a containing liner, a dosing chamber for preparing at least one pharmaceutical product accommodated within the containing liner, and a pneumatic ventilation device for feeding two air flows through the dosing chamber and through the containing liner, respectively. Operation of the pneumatic ventilation device is selectively controlled so that the containing liner has inside a pressure lower than a pressure existing within the dosing chamber and than a pressure existing in the environment outside the containing liner itself.

A microfluidic apparatus includes a substrate defining a microchannel having inlet and an outlet defining a length of the microchannel. The microchannel has a main channel extending from the inlet to the outlet, and a plurality of side cavities extending from the main channel. The cavities are in fluid communication with the main channel. A method includes introducing a sample into the microchannel through the inlet to fill the entire microchannel, and then introducing a solvent into the microchannel through the inlet at a controlled flow rate and inlet pressure. A developed solvent front then moves along the main channel from the inlet to the outlet while displacing the sample in the main channel. Images of the microchannel are acquired as the front moves, and a miscibility condition is determined based on the images.

The present disclosure provides apparatuses and methods related to a high pressure processing device that is configured to simplify batch processing. In an embodiment, a high pressure processing device includes a processing module configured to reduce a particle size of a material or achieve a desired liquid processing result for the material, a pump configured to pump the material to an inlet of the processing module, a recirculation pathway configured to recirculate the material from an outlet of the processing module back to the pump, an input device configured to receive at least one user input variable, and a controller configured to (i) determine a number of pump strokes for the pump based on the user input variable, and (ii) control the pump according to the determined number of pump strokes so that the material makes a plurality of passes through the processing module.