Determining the consistency of a mixture during a mixing process based on feedback from the mixer. The feedback may be indicative of the torque exerted on a motor shaft of the mixer. The consistency of the mixture may be determined based on the amount of torque, rate of change of torque, change in the rate of change of torque and/or a comparison of the torque information to a stored torque profile. The torque may be determined based on the current in the coils of a motor of the mixer (e.g., by measuring the voltage across a precision resistor in series with the coils). Alternatively, the feedback may be indicative of the angular velocity of the motor shaft, sound output by the mixer, vibration of the mixer, color of the mixture, or opacity of the mixture.

The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.

An arrangement (2; 32) for adding a first fluid component into a flow system (1; 31), said arrangement comprising: a first pump (3; 33) provided in a first component adding fluid line (5; 35) which is connecting a first system fluid line (9; 39) of the flow system (1; 31) with a first fluid component source (7; 37) comprising the first fluid component to be added into the flow system; and a second pump (13; 43) provided in a second component adding fluid line (15; 45) connected in parallel with the first component adding fluid line (5; 35), said second component adding fluid line (15; 45) connecting the first system fluid line (9; 39) of the flow system with a first fluid component source (7; 47) comprising the first fluid component to be added into the flow system.

A system for preparing a medicament for use by a medicament user includes a proportioning machine with a controller and pumping and clamping actuators to engage a fluid circuit having pumping and clamping portions that engage with respective actuators of the proportioning machine. The fluid circuit includes a mixing container that is initially empty and later filled with two different concentrated medicaments from different concentrate containers and with purified water. The proportioning machine is configured to receive purified water and to mix it with the concentrated medicaments to produce a medicament and to output the medicament to a medicament consumer in such a way that to the medicament consumer the medicament appears to be provided from a bag of medicament. Custom mini batches of medicament may be produced by varying the amount of the concentrates and water.

The present invention relates to a mixing system for a bioreactor, comprising a plurality of supply units (10), each being able to hold media for use in a bioreactor a mixing unit (30) for creating a uniform mixing of media a first feeding mechanism (20), arranged to feed media from the supply units (10) into the mixing unit (30), a control unit (40) operatively connected to the first feeding mechanism (20) and the mixing unit (30), said control unit (40) being configured to control the first feeding mechanism (20) to feed predetermined amounts of media from the plurality of supply units (10) to the mixing unit (30), and further being configured to control the mixing unit (30) to create a uniform mixing of media. The invention also relates to a method for mixing media for use in a bioreactor.

A method is provided for monitoring a flow behavior of mixed components without requiring additional instrumentation or sampling. The method is carried out by determining ratios of the power required to rotate a mixing impeller at different rotational speeds and then comparing the ratios. Characteristics about the mixed components are determined based on differences between the ratios.

A diluted solution production method of the present invention is a diluted solution production method of producing a diluted solution of a second liquid by adding the second liquid to a first liquid, the method including feeding the first liquid to a first pipe; and controlling pressure in a tank that stores the second liquid to add, through the second pipe that connects the tank to the first pipe, the second liquid to the first liquid in the first pipe. Adding the second liquid includes measuring a flow rate of the first liquid or the diluted solution that flows through the first pipe; measuring a component concentration of the diluted solution; and controlling the pressure in the tank, based on the measured values of the flow rate and the component concentration, so as to adjust the component concentration of the diluted solution to a specified value.

Embodiments of the present disclosure involve methods, devices, and systems for hydrating polymers using multiple mixing chambers. Adjacent mixing chambers may be coupled using an under-over baffle, and each mixing chamber may be generally rectangular with rounded corners.

This disclosure features methods of forming chemical compositions. The method includes (1) mixing a plurality of continuous material flows in a mixing tank to form a chemical composition, each continuous material flow including at least one component of the composition; and (2) moving a continuous flow of the chemical composition to a packaging station downstream of the mixing tank. The mixing and moving steps are performed continuously. This disclosure also features systems that can be used to perform such methods.

A method for operating a mixing apparatus of a manufacturing plant comprises supplying multiple powdered products to the mixing apparatus. An inlet mass flow rate of the multiple powdered products into the mixing apparatus and a weight of the multiple powdered products in the mixing apparatus are measured. The multiple powdered products in the mixing apparatus are mixed to form a mixed product. The weight of the multiple powdered products in the mixing apparatus and an outlet mass flow rate of the mixed product from the mixing apparatus are predicted based on the measured inlet mass flow of the multiple powdered products. The predicted outlet mass flow rate of the mixed product from the mixing apparatus is corrected based on the measured weight of the multiple powdered products in the mixing apparatus. The mixed product is processed into final products