A manual mixer serves to facilitate mixing and agitating materials for use during surgery. For example, the manual mixer includes a body portion defining an interior area, a mixing assembly provided in the interior area of the body portion, a crank assembly for actuating the mixing assembly, and a valve assembly. The mixing assembly serves to mix and agitate the materials provided in the interior through rotation of a plunger portion and a spring attached thereto, and through upwards and downwards movement of the plunger portion in the interior area. Rotation of the crank assembly serves to rotate the plunger portion and the spring attached thereto, and effectuate upwards and downwards movement of the plunger portion. The valve assembly can be opened to facilitate dispensing of the materials from the interior area.

The application relates to a vacuum mixing device for bone cement, where the monomer is pressed into a mixing container due to the surrounding vacuum and a gas volume present in the monomer container.

An injecting machine includes an injection cylinder, a plunger, a plunger moving mechanism, and a mixing mechanism. The plunger is reciprocally received in the injection cylinder for moving between an advanced position and a retracted position, with the injecting a liquid mixture of two different liquid materials as the plunger moves to the advanced position. The plunger moving mechanism causes the plunger to move between the advanced position and the retracted position. The mixing mechanism is disposed on the injection cylinder for mixing the two different liquid materials together to feed the liquid mixture into the injection cylinder. The plunger includes a front portion having a helical groove formed on an outer circumferential surface thereof to allow the liquid mixture fed from the mixing mechanism to pass through the helical groove for collecting in a forward space formed forward of the front portion of the plunger.

A device for mixing bone cement material, the device comprising a mixing body having a chamber, and wherein the mixing body has an open end; a lid arranged to be fitted to the open end; means for mixing bone cement material in the chamber, the means for mixing comprising a rod extending through the lid and into the chamber, wherein the rod has a frangible portion; said lid comprising a cap moveable to a first position covering the frangible portion of the rod, and to a second position revealing the frangible portion.

A container for bone cement includes a first member defining a chamber, which contains a first ingredient. The chamber also includes a second member movably coupled to the first member. The second member includes a mixing device that is movably disposed within the first chamber, and the second member defines a second chamber containing a second ingredient. The container additional includes an opening device that selectively opens the second chamber and allows the second ingredient to enter from the second chamber into the first chamber. The mixing device is movable within the first chamber to promote mixing of the first ingredient and the second ingredient to prepare the bone cement. A corresponding method of preparing bone cement also disclosed.

One aspect relates to a device for mixing a polymethyl methacrylate bone cement formed of two starting components and for storing the starting components of the bone cement. The device has a tubular cartridge with a cylindrical interior. A powder is contained in a front of the cartridge and a container containing a monomer liquid is arranged in a rear of the cartridge. A discharge piston is arranged between the container and the powder, and a conveying piston is on the side of the container opposite the discharge piston. The discharge piston and the conveying piston are arranged in the interior of the cartridge movably in the longitudinal direction. A conduit is provided that connects the front part and the rear part of the interior of the cartridge to one another in a manner permeable for the monomer liquid and for gases and which is impermeable for the powder.

An assembly for preparing and dispensing a paste, preferably bone cement, includes a cylinder containing a powder and a receptacle containing a liquid. A piercing device is configured to open the receptacle to allow liquid to flow into the cylinder to be mixed with the powder. The receptacle is collapsed by a differential pressure between the cylinder and the receptacle.

The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.

The present invention involves the use of a small profile device for preparation and/or delivery of cold slurry into the human body. The cold slurry can be generated within the device itself or within a separate small chamber, both of which produce a cold slurry using a cooling source and an injectable fluid. The delivery device provides continued agitation to the fluid/slurry through rotation and/or vibration of blades within the device. The fluid/cold slurry is cooled/kept cool through the use of an external cooling device, such as a cooling sleeve, that at least partially surrounds the delivery device. The cooling sleeve can cool or maintain the temperature of the cold slurry through a number of mechanisms. The cold slurry can be delivered using a device in accordance with the present invention to any tissue inside the body, including subcutaneous fat, visceral fat, and brown fat.

A mixing device comprises a mixing space for mixing bone cement, at least one mixing element supported in the mixing space such that it can rotate, a gear for rotating the at least one mixing element, and at least one elastically deformable energy-storing element that is connected to the gear such that the gear can be driven by an elastic energy from the energy-storing element and such that the at least one mixing element can be rotated in the mixing space by means of the gear upon the release of elastic energy from the energy-storing element. Additionally, a vacuum mixing system and mixing method comprise the mixing device for mixing the bone cement.