A cold brew coffee extraction device for adjusting the sonic vibration based on the sound signal includes: a current support extended in one direction and configured to apply an alternating current in a tangential direction of an outer peripheral portion; a magnetic vibrator accommodating one end of the current support therein, and configured to generate a magnetic field in a direction of crossing over the current support to be vibrated in a longitudinal direction of the current support due to a change in a polarity of the alternating current; a plate coupled to the magnetic vibrator to transmit the vibration to a fluid including a particulate matter; and a vibration adjustment circuit configured to, in a first mode, adjust the vibration only based on setting information inputted through a user interface, and in a second mode, to adjust the vibration based on the setting information and an external sound source.

Disclosed are mixing apparatus adapted to provide mixing of components in an automated analyzer. The mixing apparatus includes a reservoir configured to contain a coupling liquid, a transducer configured to be driven at a frequency and communicate with the coupling liquid, and a signal generation unit configured to provide a phase modulatable drive signal to the transducer. In some embodiments, improved patient sample and reagent mixing may be provided. Systems and methods are provided, as are other aspects.

A disposable fluid transfer and mixing device is disclosed and includes an injector support surface for receiving an injection device thereon. A lyophilized drug vial, a diluent vial and a syringe are also attached to the device. The device features fluid passageways and a manual valve that may be manipulated so that the syringe may be used to transfer diluent from the diluent vial to the lyophilized drug vial, for reconstitution of the drug. The valve may also be configured so that the reconstituted drug is transferred from the lyophilized drug vial to the injection device. An automated transfer and mixing device receives an injection device, a lyophilized drug vial and a diluent vial and transfers diluent from the diluent vial to the lyophilized drug vial and shakes or vibrates the lyophilized drug vial to reconstitute the drug. The device then transfers the reconstituted drug from the lyophilized drug vial to the injection device.

A reciprocating motion disk for mixing wastewater in a tank of a treatment plan is optimized for geometry, along with cycling speed and stroke length, to cause effective mixing velocity throughout the tank.

An automated transfer and mixing device receives an injection device, a lyophilized drug vial and a diluent vial and transfers diluent from the diluent vial to the lyophilized drug vial and shakes or vibrates the lyophilized drug vial to reconstitute the drug. The device then transfers the reconstituted drug from the lyophilized drug vial to the injection device.

Embodiments provide a wet disperser for dispersing particulates in a mixture containing at least a dispersing medium and particulates. According to various embodiments, the wet disperser includes a through channel extending from an inflow port to an outflow port, and a mixture-passing plate having at least one passing hole defined. In the wet disperser, the through channel includes, on a downstream side of the through channel from a position provided with the mixture-passing plate, a dispersion part having a vibration body provided such that vibration causes at least a part of the vibration body to come into contact with at least a part of an opening periphery of the passing hole, and an inside surface defining the passing hole of the mixture-passing plate.

Embodiments disclose an apparatus and methods for biological sample processing enabling isolation and enrichment of microbial or pathogenic constituents from the sample. A vessel for sample containment and extraction is further disclosed for engagement with a transducer capable of efficient sample disruption and lysis. Together these components provide a convenient and inexpensive solution for rapid sample preparation compatible with downstream analysis techniques.

A microfluidic device and a system comprising such a microfluidic device or chip and a method for mixing and distributing fluids using said chip or system, wherein the microfluidic device for mixing and distributing fluids, formed by bonding of a first substrate and a second substrate, wherein open formations on bonded the first and second substrate form at least part of a microfluidic channel network comprising at least one microstructure comprising a single receiving chamber which is connected by at least one first channel extending from said single receiving chamber leading into an at least first target chamber, wherein the at least one first channel extends clockwise or counter clockwise from the single receiving chamber and is bowed in a clockwise or counter clockwise direction.

The invention provides a method for producing prion protein having an aggregated conformation by contacting native conformation prion protein with aggregated conformation prion protein in a liquid preparation and subjecting this to at least one cycle or to a number of cycles of application of shear-force for fragmenting aggregates of prion protein, wherein the shear-force applied is precisely controlled. In addition to this process for amplification of aggregated state prion protein from native conformation prion protein, the invention relates to the aggregated state prion protein obtained by the amplification process, which aggregated state prion protein has one conformation, which is e.g. identical within one batch and reproducible between batches, e.g. as detectable by proteinase resistance in a Western blot.

The disclosure describes methods and devices with which to process and analyze difficult chemical, biological, environmental samples including but not limited to those containing bulk solids or particulates. The disclosure includes a cartridge which contains a separation tube as well as one or more valves and cavities for receiving raw sample materials and for directing and containing various fluids or samples. The cartridge may contain a separation fluid or density medium of defined density, and structures which direct particulates toward defined regions of the cartridge. Embodiments can include a rotational device for rotating the cartridge at defined rotational rates for defined time intervals. Embodiments allowing multiple assays from a single sample are also disclosed. In some embodiments, this device is used for direct processing and chemical analysis of food, soil, blood, stool, motor oil, semen, and other samples of interest.