Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.

A method for crystallizing calcium nitrate from an aqueous calcium nitrate composition including from 6 to 12 weight % nitric acid, from 11 to 17 weight % phosphoric acid, and from 36 to 49 weight % dissolved calcium nitrate, which aqueous composition is optionally directly obtainable from digesting phosphate rock in nitric acid. The method includes filling at least one vertical crystallizing tank through an inlet with the aqueous calcium nitrate composition. The crystallizing tank includes a vertical cylindrical section, a first inlet, a first outlet, a second inlet, three concentric banks of cooling coils, an agitator, and a temperature measurement device. The method includes circulating through the banks of cooling coils a cooling fluid, having an initial temperature ranging from 40 C. to 5 C., and rotating the agitator such that a minimum average heat transfer of 400 W/m.sup.2.Math.K is achieved on the cooling coil the most distant from the agitator.

Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.

A homogenous mixing apparatus is provided that includes a circulation unit, a dynamic mixing unit, wherein a feeding port of the first-stage dynamic mixing device communicates with the discharging end of the circulation unit, a discharging port of the third-stage dynamic mixing device communicates with the feeding end of the circulation unit, and each of the dynamic mixing devices includes a dynamic mixer; and a control unit, configured to be capable of controlling the dynamic mixing unit, so that the dynamic mixers of the first-stage, second-stage, and third-stage dynamic mixing device are capable of being independently started and shut down and operated at independent rotating speeds, wherein the dynamic mixers each includes a stator and a rotor, rotating speed ranges of the dynamic mixers of the first-stage, second-stage, and third-stage dynamic mixing device increase in sequence, and distances between the rotors and the stators decrease in sequence.

The systems and methods disclosed herein provide for the efficient generation of fine bubbles. In particular, systems and methods for use in bioreactors are disclosed herein providing a superior means to produce useful fermentation products by the biological fermentation of fine bubble waste substrates injected into a liquid broth containing a microorganism culture.

Methods for the production of foamed sclerosant compositions are provided. Containers include a container body including one or more sidewalls extending between a top and a bottom of the container body and a bottom surface, a foaming space being defined in an interior of the container body. The foaming space contains a sterile gas and a mixing element configured to be operatively coupled with a rotatable actuator without the actuator entering into the foaming space. The container includes a female coupling member for mating with a syringe, and a pressure equalizer for equalizing a pressure inside the foaming space with a pressure outside the foaming space. Systems and kits including such containers are also provided. Also disclosed are methods for the preparation of a sclerosant foam which may include a pressure release before extraction of the foam and/or a continued rotation of the actuator while the foam is being extracted.

The invention relates to a mixing conveyor for an injection molding system, in particular a thixomolding injection molding system, or the like for conveying a granule-powder mixture, comprising the following: a mixing container (10), with at least one feed (11, 13) for granular material (12) and/or powdery material (14); and at least one mixing device (13a, 13b, 13c, 13d) which is designed to mix the granular material (12) and the powdery material (14) to form a granule-powder mixture; and a mixing container outlet (15), which can be arranged in particular in the vicinity of a melting area (51) of the injection molding system (50) or the like, and is designed to discharge the granule-powder mixture or to feed it to the injection molding system (50) or the like for at least partial melting.

A reciprocating motion disk for mixing wastewater in a tank of a treatment plan is optimized for geometry, along with cycling speed and stroke length, to cause effective mixing velocity throughout the tank.

Bioreactors are provided that include a vessel and a jet mixer disposed in the vessel. Methods that utilize the bioreactors are provided, involving placing a microorganism or cells and a fluid medium in the bioreactor.

The present disclosure relates to a process for the preparation of polyethylene by polymerizing in a slurry ethylene and optionally one or more C.sub.3 to C.sub.10 alpha-olefins. In some embodiments, the polymerization is carried out in a cylindrical polymerization reactor equipped with an agitator for mixing the contents of the reactor and inducing a flow of the slurry, the ethylene is fed into the reactor by an ethylene injection system comprising one or more injection nozzles which project through the bottom reactor head or through the reactor wall and extend from 0.02-0.5 times the inner diameter D into the reactor, and the ethylene exits the injection nozzle with an exit velocity from 10-200 m/s.