Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.

Disclosed is a venturi air-ammonia mixer 200 enabled for a two-burner system. The venturi air-ammonia mixer 200 comprises a venturi body 204 and an annular region 212. Further the venturi body 204 comprises a convergent section 204(a) comprising an air inlet feed 208 a cylindrical section 204(b) comprising an inner hollow member 202, and a divergent section 204(c) comprising an air-ammonia gas outlet 210. Further the cylindrical section 204(b) and the inner hollow member 202 comprises a first perforated region and a second perforated region. Further the cylindrical section 204(b) is enclosed in the annular region 212 and connected to an ammonia inlet feed 206. Further the ammonia inlet feed 206 fills the annular region 212 with dry ammonia gas which further flows into the venturi air-ammonia mixer 200 through the perforated regions thereby enabling uniform mixing of the ammonia gas with air from the air inlet feed 208.

A mixer configured for releasing large bubbles into wastewater is provided. The mixer can include a central draft tube, an upwardly-extending member surrounding the draft tube, and an accumulator surrounding both the upwardly-extending member and the draft tube. A lower end of the draft tube sidewall may be sealed and not include any openings beneath the lower end of the upwardly-extending member, so as to prevent liquid pumpage through the draft tube. A method for treating wastewater in a system that includes at least one large bubble mixer and at least one fine bubble diffuser is also provided. The large bubble mixer and fine bubble diffuser may be supplied gas independently from one another. The method can include multiple modes of operation wherein gas is either supplied to the mixer, to the diffuser, to neither the mixer or the diffuser, or to both the mixer or the diffuser.

An enzymatic processing plant for continuous flow-based enzymatic processing of organic molecules. The enzymatic processing plant including an enzymatic processing area, wherein the enzymatic processing area includes a turbulence-generating pipe with a repeatedly changing centre-line and/or a repeatedly changing cross-section, for generating turbulence to mix a reaction mixture and prevent sedimentation of particles as the reaction mixture is flowing through the turbulence-generating pipe. The enzymatic processing plant and the enzymatic processing area are arranged such that the reaction mixture is subjected to turbulence within the enzymatic processing area for a reaction time of 15 minutes or more.

The disclosure provides an apparatus for storing platelet-rich plasma (PRP). The apparatus is configured to reversibly receive a platelet-rich plasma (PRP) container. The apparatus comprises a platform defining at least one recess configured to receive the PRP container therein; and an agitator configured to move the platform, and thereby agitate PRP stored in the PRP container. The agitator is configured to move the platform in a circular motion at a frequency of between 10 and 10,000 revolutions per minute (RPM).

Embodiments relate continuous process for treating tailings that includes providing tailings for treatment having at least 20 wt % solids, providing a mixing apparatus having a first inlet for feeding the tailings, a second inlet for feeding flocculants, an outlet for a mixture of the tailings and flocculants, and a rotating disk, the first inlet being separate from the second inlet, the second inlet being above the rotating disk, and the rotating disk having a tip speed at least 2 m/s, continuously introducing into the mixing apparatus the tailings through the first inlet and the flocculants through the second inlet, allowing the tailings and the flocculants to mix on the rotating disk to form the mixture of the tailings and flocculants, continuously removing the mixture of the tailings and flocculants through the outlet to form a treated mixture, and flowing the treated mixture from the mixing apparatus for further treatment or to a disposal area.

A method for producing a sealant includes a weighing and mixing step, a kneading step, a stirring and defoaming step, and a filling step. In the weighing and mixing step, a main component and a curing agent are weighed and mixed together. In the kneading step, the mixture mixed in the weighing and mixing step is kneaded. In the stirring and defoaming step, the kneaded product kneaded in the kneading step is stirred and defoamed. In the filling step, the kneaded product defoamed in the stirring and defoaming step is filled into a container. In the stirring and defoaming step, the kneaded product is stirred under a condition wherein a stirring rotational speed at which the kneaded product is stirred and a stirring time for which the kneaded product is stirred are within a range from an arithmetic product lower limit value to an arithmetic product upper limit value.

Embodiments of the present application relate to commercial manufacturing processes for making bupivacaine multivesicular liposomes (MVLs) using independently operating dual tangential flow filtration modules.

Embodiments of the present application relate to commercial manufacturing processes for making bupivacaine multivesicular liposomes (MVLs) using independently operating dual tangential flow filtration modules.

Disclosed is a method for managing the operation of an apparatus for injecting oxygen into a purification basin. The oxygen notably being used by the biomass present in the purification basin to consume the pollution present in an effluent feedstock contained in the basin. The method comprises varying a rotational speed of the shaft by using a frequency variator, wherein an applied variation in speed is between plus 15% and minus 15% of the nominal speed of the shaft.