The present invention relates to a chiral spiro phosphine-nitrogen-sulfur (PNS) tridentate ligand, preparation method and application thereof. The PNS tridentate ligand is a compound represented by Formula I or Formula II, their racemates, optical isomers, or catalytically acceptable salts thereof. The ligand has a primary structure skeleton characterized as a chiral spiro indan skeleton structure with a thio group. The chiral spiro phosphine-nitrogen-sulfur tridentate ligand can be synthesized by reacting racemic or optical active compound 7-diary/alkyl phosphine-7-amino-1, 1-spiro-dihydro-indene compound having a spiro-dihydro-indene skeleton as the starting material. The chiral spiro PNS tridentate ligand being complex with transition metal salt can be used in an asymmetric catalytic hydrogenation reaction for catalyzing carbonyl compound. In particular, in asymmetric hydrogenation reaction process, being complex with iridium for catalyzing -alkyl--keto ester can obtain a high catalytic activity (a catalyst amount of 0.0002% mol) and high enantioselectivity (up to 99.9% ee) result. So the present invention has a practical value for industrial and commercial production. ##STR00001##

The present disclosure provides a method for efficiently producing and providing compounds having a spirooxindole skeleton, for example compounds having a spirooxindole skeleton and having antitumor activity that inhibit the interaction between Mdm2 protein and p53 protein, or intermediates thereof, using an asymmetric catalyst. Compounds having optically active tricyclic dispiroindole skeletons are obtained through catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid.

A catalyst for a hydrogenation reaction including a polymer support and a catalytic component supported on the polymer support. The polymer support consists of a repeating unit represented by any one of Formulae 5 and 7 to 13.

A slurry-phase catalyst composition may include a disulfide oil and a first metal complex. The first metal complex may include at least one transition metal selected from the group consisting of molybdenum, cobalt, nickel, tungsten, iron, and combinations of these. The first metal complex may also include a plurality of ligands bonded to the at least one transition metal. The plurality of ligands may include at least one first ligand selected from the group consisting of dim ethyl sulfide, dimethyldisulfide, diethyl sulfide, diethyldisulfide, methyl ethyl sulfide, methylethyldisulfide, and combinations thereof, and the transition metal may be bonded to a sulfur atom of the at least one first ligand.

The present invention relates to ligands based on calixarenes, metal complexes including such ligands and their use as homogeneous or heterogeneous catalysts.

The invention provides a method for synthesizing musk macrocycles comprising contacting an easily accessible diene starting materials bearing a Z-olefin moiety and performing a ring closing metathesis reaction in the presence of a Group 8 olefin metathesis catalyst.

The present invention relates to a selective reduction of specific aldehydes and ketones to their corresponding alcohols.

The present invention relates to a catalyst system comprising a transition metal compound on a solid carrier which is a surface-reacted calcium carbonate. The invention further relates to a method for manufacturing said catalyst system and to its use in heterogeneous catalysis.

A 4,4-divinylazoarylene-bridged diruthenium complex with a general formula [{Ru(CO)(L-?.sup.2[N,S].sup.?)(P.sup.iPr.sub.3).sub.2}.sub.2(?{CH?CHC.sub.6H.sub.2(.sup.iPr).sub.2-2,6}.sub.2N?N-4,4)], its synthesis, and its use as an catalyst in inorganic processes.

Embodiments in accordance with the present invention encompass an organoruthenium compound of the formula I: (I) wherein X, Y, L.sub.1, L.sub.2, L.sub.3, R.sub.1 and R.sub.2 are as defined herein. Also disclosed herein are the use of organoruthenium compound of the formula I as (pre)catalysts for the olefin metathesis reactions, as well as to the process for carrying out the olefin metathesis reaction.

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