A one-to-many parallelized millireactor system capable of high throughput production in millireactors. Also disclosed is a method for carrying out multi-phase reactions.

A flow control device, a system and a method are disclosed. The flow control device comprises a displaceable means (101) having a direction of displacement and being displaceable between a first position and a second position. The flow control device further comprises a body (110) comprising a first cavity (102) in fluid contact with a first side of the displaceable means (102) forming a first volume. The first cavity further comprising a first inlet (103), a primary outlet (104) with a primary flow resistance and arranged essentially parallel with the displacement direction, wherein the primary outlet comprises an inlet opening (105) facing the displaceable means at a first distance (106) from the displaceable means in the direction of displacement, a secondary outlet (107) with a secondary flow resistance, wherein the displaceable means is displaceable between a first position and a second position. In the first position, a first fluid path (108) between the first inlet (103) and the primary outlet (104) is provided, and a second flow path (109) between the inlet (103) and the secondary outlet (107) is provided; In the second position, the displaceable means is displaced at least the first distance and close the inlet opening (105) of the primary outlet, whereby the inlet opening (105) is blocked, and the second fluid path (109) between the first inlet (103) and the secondary outlet (107) is maintained.

The present invention provides improved automated systems and methods for synthesis of biopolymers including DNA and RNA. The automated systems and methods represent a number of improvements over existing systems for multiplex synthesis of biopolymers in a combinatorial fashion.

The present invention relates to a parallel synthesis method and synthesizer of a compound library, and more specifically provides a parallel synthesis method and synthesizer of a compound library, which uniformly distribute a first reactant and perform independent reactions in separate spaces, and since it is possible to confirm the results for various reaction variables at once, the synthesis time of the compound library can be reduced with a high synthesis yield of the product.

Multi-stage sample-recovery systems, including automated 2-stage and 3-stage sample-recovery systems, are provided. Such systems enable the rapid screening and recovery of samples, including viable cell-based samples, from high-throughput screening systems, including systems utilizing large-scale arrays of microcapillaries. In specific screening systems, each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be identified and recovered using the multi-stage systems disclosed herein.

The invention relates to an apparatus for analyzing reactions, comprising at least one reactor (1) and at least two sample vessels (13), wherein, in the case of an apparatus having one reactor (1), the reactor (1) is connected to at least two sample vessels (13), and, in the case of an apparatus having more than one reactor (1), each reactor (1) is connected to at least one sample vessel (13). The invention further relates to a method of analyzing reactions in such an apparatus.

The invention relates to an apparatus for analyzing heterogeneously catalyzed reactions comprising at least one reactor (3) through which a particulate catalyst flows and at least one reactant feed, wherein arranged downstream of each reactor (3) is a separation apparatus (17) for separating the particulate catalyst from a reaction product comprising condensable gases and arranged downstream of the separation apparatus (17) is a liquid separator (31) for separating liquid constituents from the reaction product, wherein the liquid separator (31) comprises a metallic tube (103) and a deflection body (119), wherein the metallic tube (103) is closed at its ends and the deflection body (119) is accommodated in the metallic tube (103) and the metallic tube (103) comprises a side feed (135) at a first end (105) and a gas outlet (113) at a second end (107) and the gas outlet (113) is connected to at least one sample vessel (37). The invention further relates to a process for analyzing heterogeneously catalyzed reactions in the apparatus.

Provided are a test device and a test method. In the test device, sample feeders feed samples to a catalyst at a preset flow rate, and each of multiple reaction vessels includes a catalyst layer filled with the catalyst. Feed side switching valves connect a feed flow path through which the samples are fed, to a feed destination reaction vessel, and an outflow side switching valve connects a sample flow path intended to collect the samples for analysis, to an outflow source reaction vessel through which the sample flows out of the catalyst layer. A control unit performs a switching control of the feed destination reaction vessel and the outflow source reaction vessel with the feed side switching valves and the outflow side switching valve, such that a reaction rate test is performed under at least three conditions having different residence times in the catalyst layer.

A system includes a nucleic acid amplification module configured to receive deoxyribonucleic acid (DNA) template and to generate a nucleic acid product from the DNA template utilizing an amplification reaction while performing real-time inline monitoring of the amplification reaction via a plurality of sensors. The system also includes a purification module configured to purify the nucleic acid product. The nucleic acid amplification module and the purification module are each automated and form a functionally closed system.