A fluidic network for carrying out, in parallel, a plurality of analyses of biological samples is disclosed. The network has a flow cell array with a plurality of reaction chambers. The reaction chambers each have a first channel connection and a second channel connection. The first channel connections are connected to a first supply channel and the second channel connections are connected to a second supply channel. The first supply channel and the second channel connection are interconnected by a circulation line. At least one component is connected to the circulation line so that component test reagents can be introduced into the reaction chambers of the flow cell array.

A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyzes. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyzes requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyzes.

A one-to-many parallelized millireactor system capable of high throughput production in millireactors. Also disclosed is a method for carrying out multi-phase reactions.

The present disclosure relates to a method of depositing a fluid onto a substrate. In some embodiments, the method may be performed by mounting a substrate to a micro-fluidic probe card, so that the substrate abuts a cavity within the micro-fluidic probe card that is in communication with a fluid inlet and a fluid outlet. A first fluidic chemical is selectively introduced into the cavity via the fluid inlet of the micro-fluidic probe card.

An improved apparatus for oligonucleotide synthesis that reduces reagent consumption and increase yield, typically comprising one or more synthesis vessels, each having a waste emitting end, a drain block located below and operably coupled to the synthesis vessel(s), a sealing device disposed between the synthesis vessel(s) and the drain block, one or more waste collection reservoirs located inside of the drain block, one or more equilibration holes, each equilibration hole penetrating an exterior of the drain block and the waste collection reservoir(s), one or more waste tubes leading from the waste collection reservoir(s), each waste tube comprising a waste valve. In some embodiments the sealing device may comprise one or more sealing blocks, and the equilibration holes may be located in the sealing blocks in lieu of in the drain block. In some embodiments, each equilibration hole may be operably coupled to a solenoid or flow control valve.

Provided is a full-automatic radiopharmaceutical production apparatus including a synthesis device. The synthesis device includes a synthesis cassette and a main synthesis unit. The synthesis cassette includes a synthesis cassette body. The synthesis cassette body includes a first common pipe extending in a left-right direction. The first common pipe is located between three-way valves that are adjacent in the left-right direction. The main synthesis unit includes a main synthesis unit frame. The first common pipe is detachably fixed at a front housing of the main synthesis unit frame by a first fixing assembly.

A reactor system is disclosed. The reactor system includes a vessel configured to contain a solid support, the vessel including: a vessel wall defining a reaction chamber, the reaction chamber having a first end and a second end opposite the first end; a piston operatively arranged at the first end and configured to translate within the reaction chamber; a force measuring device coupled to the piston and configured to measure a load on the piston; a piston driver coupled to the piston; and a processor operably coupled to the force measuring device and the piston driver, the processor configured to: measure a load on the piston using the force measuring device, and adjust a position of the piston using the piston driver based on measuring the load on the piston.

Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.

The present invention relates to a method of manufacturing a diester-based compound, and, more particularly, to a method of manufacturing a diester-based compound, which is performed using a continuous process including a reaction part in which a total of n reaction units spanning from a first reaction unit to an nth reaction unit are connected in series, wherein each of the reaction units includes a reactor, and the method includes: supplying a feed stream including a dicarboxylic acid and an alcohol into the first reactor; esterifying the feed stream to prepare a reaction product; and supplying a lower discharge stream including the reaction product into the reactor of the rear reaction unit. In this case, a conversion rate of the esterification reaction in the first reactor is controlled in a range of 50 to 80%.

Provided is a method of preparing a diester-based material, more particularly, a method of preparing a diester-based material, which is carried out by a continuous preparation process of a diester-based material including a reaction part in which a total of n reaction units from a first reaction unit to an nth reaction unit are connected in series, the reaction unit including a reactor which esterifies dicarboxylic acid and alcohol, including: esterifying dicarboxylic acid and alcohol in a reactor of the first reaction unit to produce a reaction product, and supplying a lower discharge stream including the reaction product to a reaction unit at a rear end through a lower discharge line; and supplying a liquid material through a liquid supply line connected to a lower discharge line of the reactor of the first reaction unit.