The invention refers to a modular continuous flow device for automated chemical multistep synthesis under continuous flow conditions. The device comprises a plurality of different types of continuous flow modules and a valve assembly for connecting the continuous flow modules to each other in a parallel or radial manner. This arrangement allows conducting chemical reaction sequences by pre-synthesizing and intermediately storing or simultaneously synthesizing at least one intermediate product which is needed in the main synthetic reaction sequence in order to obtain the final product.

A structure having excellent rectification performance and durability and having a micro flow channel is provided. The structure has a flow channel in the inside, wherein the cross section of the flow channel has a shape in which a region surrounded by a substantially elliptical curve and a line segment is connected to a triangular region with the base being the line segment, the region surrounded by the line segment and the substantially elliptical curve is semielliptical or more, and the base angle of the triangular region is 45 degrees or more.

Provided is a fluid treatment system, including: a plurality of fluid channel devices arranged in series along a regular channel; a plurality of flow control valves each adjusting the flow rate of a treatment target fluid flowing into each of the plurality of fluid channel devices; a flow control valve provided on the upstream side of the plurality of fluid channel device and operable to change the flow rate of the treatment target fluid flowing into each of the plurality of fluid channel device; a bypass channel allowing the treatment target fluid to flow so as to bypass the fluid channel device in which abnormality has occurred, and a plurality of bypass selector valves selectable between a state of allowing the flow of the treatment target fluid in the bypass channel and a state of blocking the flow.

The present invention relates to an improved process for the preparation of trazodone. In particular, the present invention relates to a continuous process for the preparation of trazodone. More in particular, the present invention relates to a new method for the preparation of trazodone, said method comprising at least one step consisting of a continuous process performed in a flow reactor.

A flow reactor [10] includes a fluidic module [20] having an external surface [22], an internal process fluid path [24], and an input port [I] and an output port [O] connected to the process fluid path [24]. An upstream coupler [30] is connected to the input port [I], and a downstream coupler [40] is connected to the output port [O]. The upstream coupler [30] has a gasket [38] in a gasket groove [36] pressed against the fluidic module [22] and a hollow circular cylindrical post [35] protruding from the upstream coupler [32] and extending into the input port [I]. The downstream coupler [40] has a gasket [48] in a gasket groove [46] pressed against the fluidic module [20] and no hollow circular cylindrical post extending into the output port [O].

The present disclosure relates to a volume tailorable manufacturing system for quality assured manufacturing of biosafety level classified biopharmaceutical products and a method for tailoring a production volume capability of a manufacturing system. The volume tailorable manufacturing system comprises one or more multi-product suites and a control facility configured to control a unidirectional flow in a circulation system of the one or more multi-product suites. The circulation system is configured to interconnect the one or more multi-product suites and comprises separated supply and return systems. The supply system comprising at least one inlet, the return system comprising at least one outlet that is paired with the inlet and provided at a spatially predetermined position from the inlet, and each inlet/outlet pair comprises a seal when not connected to an adjacent multi-product suite.

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

A flow reactor [10] includes a fluidic module [20] having an external surface [22], an internal process fluid path [24], and an input port [I] and an output port [O] connected to the process fluid path [24]. An upstream coupler [30] is connected to the input port [I], and a downstream coupler [40] is connected to the output port [O]. The upstream coupler [30] has a gasket [38] in a gasket groove [36] pressed against the fluidic module [22] and a hollow circular cylindrical post [35] protruding from the upstream coupler [32] and extending into the input port [I]. The downstream coupler [40] has a gasket [48] in a gasket groove [46] pressed against the fluidic module [20] and no hollow circular cylindrical post extending into the output port [O].

Disclosed are modular chemical reaction systems and methods of using such chemical reaction systems. The disclosed systems can have a substrate layer and a plurality of modules selectively mounted to an outer surface of the substrate layer. The substrate layer can include flow connectors that cooperate with the modules to form a fluid flow pathway for performing at least one step of a chemical reaction. At least one of the modules can be a process module, such as a reactor or separator. The modules can also include at least one regulator module. The system can also include at least one analysis device that analyzes at least one characteristic of the chemical reaction as the reaction occurs. The system can also include processing circuitry that monitors and/or optimizes the chemical reaction based on feedback received from the analysis device or other system components.

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.