A chemical reactor and method for operation. The reactor enables N pairwise fluid contacts among k chemical fluids, with k2 and N4 and comprises: a reaction layer extending in a plane subtended by two directions; N chemical cells, each including two circuit portions, designed for enabling circulation of two of the k chemical fluids, respectively, the two circuit portions intersecting each other, thereby enabling one pairwise fluid contact for the two of the k chemical fluids; and a fluid distribution circuit comprising: k sets of inlet orifices sequentially alternating along lines parallel to one of the two directions, for respectively dispensing k chemical fluids to the reaction layer; and k sets of outlet orifices sequentially alternating along lines parallel to the inlet orifices, for respectively collecting k chemical fluids from the reaction layer, and wherein, each circuit portion connects an inlet orifice to an outlet orifice.

This specimen treatment chip includes: a first fluid module having a first flow channel for performing a first treatment step on an object component in a specimen; a second fluid module having a second flow channel for performing a second treatment step on the object component subjected to the first treatment step; a substrate; and a connection flow channel for connecting the first fluid module and the second fluid module disposed on the substrate.

The invention relates to a flow element for transferring fluids comprising a capillary cartridge (1) having an integrated capillary line (3). The capillary cartridge according to the invention (1) has a ring-shaped channel (8) and securing grooves (6, 6), wherein the flow element is characterized in that the capillary line (3) is arranged in the ring-shaped channel (8). The ends of the capillary lines (3) are connected to connection elements (9) in which securing grooves (6, 6) are secured in a positive locking manner. The flow elements according to the invention contribute toward improved manageability and effectiveness of components. In a preferred embodiment, the flow elements are used as a distribution system in the form of a plurality of capillary cartridges (1-1, 1-2, . . . ). Such distribution systems are of technical importance in the field of catalyst testing apparatuses with reactors arranged in parallel.

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

A drug provision system includes a slot to which a kit can be attached and detached, the kit including a raw ingredient space into which a raw ingredient of a drug is filled and a reactor for mixing the raw ingredient that flows from the raw ingredient space with another raw ingredient; a raw ingredient feeding mechanism that moves the raw ingredient within the raw ingredient space to the reactor in the kit in which a blocking unit has been released to mix the raw ingredients within the kit; and a collection mechanism that collects a drug within the reactor prepared by mixing the raw ingredients from the kit.

A fluid transport apparatus includes a pressure chamber to which a fluid is supplied, N drive elements that deliver the fluid to a channel by changing pressure of the fluid within the pressure chamber, and a control section that supplies a drive signal to each of the drive elements. The control section controls the N (N2) drive elements such that phases of drive signals which are supplied to each of the drive elements are different from each other. Therefore, by changing the pressure of the fluid within the pressure chamber while suppressing an amplitude of the drive elements as a whole, pulsation of the fluid is effectively suppressed.

A method of performing a reaction is disclosed comprising flowing a reaction mixture (50) comprising HF past a compression seal (40) within a flow reactor (20), wherein the compression seal (40) includes an O-ring or gasket (30, 32) and where the O-ring or gasket (30, 32) comprises fluoroelastomer (to include fluoroelastomers and perfluoroelastomers), while maintaining the reaction mixture comprising HF at a temperature of 50 C. or greater [generally at a temperature in the range of from 50 C. and greater (60, 70, 80, 90, 100, 120, 150, and 180 C.) up to 220 C.], using O-rings or gaskets (30, 32) that comprise a fluoroelastomer having a pre-use tensile strength in the range of from 0.1 to 14 MPa measured according to IS037, and desirably further having a compressive set in the range of from 0 to 12% measured according to IS0815.

A check-valve comprises: a thin sheet and a thick sheet; flow paths for flowing fluid which are formed by penetrating the thin sheet and the thick sheet; a flow-in chamber and a flow-out chamber which are connected to the flow paths; a partition sheet which is bonded to the thin sheet and the thick sheet while being sandwiched therebetween, and has a flexible inner flange which projects in cavities of the flow-in chamber and the flow-out chamber and does not close the flow-out valve chamber by flexing toward the flow-out valve chamber in a normal flow, and closes the flow-in valve chamber by flexing toward the flow-in valve chamber in a reverse flow; and a through-pass hole which is opened at the partition sheet and connects the both valve chambers.

A one-to-many parallelized millireactor system capable of high throughput production in millireactors. Also disclosed is a method for carrying out multi-phase reactions.

The present invention relates to an automated radiosynthesis device adapted for enhanced automatic disconnection of a disposable kit once a radiosynthesis has been carried out. The automated radiosynthesis device of the invention therefore reduces the time to remove the disposable kit from the radiosynthesis device and reduces radiation exposure to the operator.