Provided are triaryl phosphine ligands, as shown in general formulae Ia and Ib, or a mixture thereof, and a preparation method therefor. The invention addresses the deficiencies of biaryl phosphine ligands invented by Buchwald et al. Also provided are a triaryl phosphine coordinated palladium complex, a system composed of triaryl phosphine ligand and a palladium salt or complex, and a use of the triaryl phosphine coordinated palladium complex in catalysing organic reactions, in particular a use in catalysis of coupling reactions involving (pseudo)halogenated aromatic hydrocarbon as substrate.

An organic light emitting material, a preparation method thereof, and an organic light emitting device are provided. The organic light emitting material includes oxadiazole-p-benzodioxazoles. The oxadiazole-p-benzodioxazoles has a large π-conjugated system, that is, it has good planarity and strong visible π-π* absorption. Also, it has high fluorescence quantum yield. Therefore, the oxadiazole-p-benzodioxazoles with a large π-conjugated system has a high-efficiency electron transport property, and it has a high-efficiency electron-withdrawing group to increase electron transport efficiency and improves its luminous efficiency.

The present invention relates to ligands based on calixarenes, metal complexes comprising such ligands and their use as homogeneous or heterogeneous catalysts.

The invention relates to a material in the form of a cellular solid monolith consisting of an inorganic oxide polymer. Said monolith comprises macropores which have an average size d.sub.A of 4 μm to 50 μm, mesopores that have an average size d.sub.E of 20 to 30 Å, and micropores which have an average size d.sub.1 of 5 à 10 Å, said pores being interconnected. The inorganic oxide polymer has organic groups R of formula —(CH.sub.2).sub.n—R.sup.1, wherein 0≤n≤5, and R.sup.1 is selected from among a thiol group, a pyrrole group, an amino group having one or more optional, optionally substituted alkyl, alkylamino, or aryl substituents, an alkyl group, or a phenyl group optionally having an alkyl-type substituent R.sup.2. The disclosed material can be used as a substrate for a metal catalyst and for decontaminating liquid or gaseous media.

An amphiphilic fusion protein has a formula S/I—X—H.sub.1—H.sub.2, wherein S— is a solubilizing moiety, I— is an insolubilizing moiety, —X— is a peptide sequence comprising a proteolytic or chemical cleavage site, —H.sub.1— is a hydrophilic peptide, and —H.sub.2 is a hydrophobic peptide.

Sulfonyl hydroxamic acid compounds have the following general formula: ##STR00001##
Ring A and B are aryl, heteroaryl, cycloalkyl, fused aryl or fused alkyl group, and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl, aryl, heteroaryl, halogen, hydroxy, alkoxy, aryloxy, nitro, cyano, ester, or aldehyde. The compounds are HDAC inhibitors. Processes can be used for preparation of these indole-based sulfonyl hydroxamic acid derivatives.

The disclosure includes high purity compounds having CCR5 and/or CCR2 antagonism, or salts thereof, high purity intermediates thereto and processes for synthesizing the same.

The present invention relates to an improved method of preparing metal complexes, in particular carbene-metal complexes. The method comprises the step of subjecting a salt of formula Z.sup.+—X.sup.− and a non-ionic metal salt of formula ML.sub.n or subjecting a metallate of formula Z.sup.+ . . . ML.sub.nX.sup.− to a mechanical mixing process in the presence of a base. The method allows to formation of heterocyclic carbene metal complexes such as a nitrogen-containing heterocyclic carbene (NHC)-metal complexes. The invention also relates to the use of metal complexes, in particular carbene-metal complexes such as heterocyclic carbene-metal complexes obtainable by the method according to the present invention as catalysts.

A process for producing an aromatic compound in high yield and a palladium complex are provided. The palladium complex is represented by formula (D) or formula (D′): ##STR00001##
In formula (D), X represents a chlorine atom, A represents an alkyl group having 1 to 3 carbon atoms, B represents an alkyl group having 4 to 20 carbon atoms or a cycloalkyl group having 5 to 10 carbon atoms, R.sup.4 and R.sup.5 each independently represent a hydrogen atom, a fluorine atom, or an alkoxy group having 1 to 20 carbon atoms, and R.sup.6, R.sup.7 and R.sup.8 represent a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms or a heteroaryl group having 4 to 20 carbon atoms. ##STR00002##
In formula (D′), X, A, B and R.sup.4 to R.sup.8 are the same as defined above.

The present disclosure relates to the field of pharmaceutical chemistry, in particular to a class of PARP/PI3K double-target inhibitors (I) containing structures of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine and phthalazin-1(2H)-one and a preparation method thereof. As proved by pharmacodynamic tests, the compounds of the present disclosure have PARP/PI3K double-target inhibitory activity and can be used for anti-tumor.