A microfluidic device for detecting a target gene according to the present invention comprises a plurality of capillary tubes which are partially immersed in a sample container containing sample solution and in which the sample solution flows by capillary phenomenon, and microbead packings arranged at one part in each capillary tube to be arranged on a flow path of the sample solution, wherein each of the microbead packings comprises: a packing tube arranged at the capillary tube so as to partially constitute the flow path of the sample solution, a plurality of microbeads contained in the packing tube and being in close contact with each other to form voids between the microbeads, and probe linkers formed on a surface of each microbead, wherein the probe linkers are configured to amplify a target gene in the sample solution by complementary bonding with the target gene, thereby detecting the target gene.

An object of the present invention is to provide a dispensing device that can inhibit a dead volume from occurring and can dispense a liquid of a small quantity with a high degree of accuracy while reducing the variation of dispensing quantities. A dispensing device according to the present invention has a detachable dispensing tip and the dispensing tip has a configuration of arranging a plunger in a hollow part of a metal pipe (refer to FIG. 2).

A method of obtaining a numerical model is disclosed. The numerical model correlates estimated line width values to minimum pressure for gas bubble generation (MPGBG) values. An MPGBG value of each capillary tube in the reference group is measured for a liquid. A nanoparticle composition is deposited, under standard conditions, on substrate(s) from each respective reference capillary tube, to form nanoparticle lines. A line width of each of the nanoparticle lines deposited using each respective reference capillary tube is measured by a microscope apparatus. A numerical model that correlates estimated line width values to MPGBG values for the liquid is calculated.

In a capillary of a pipette, first and second ends in a longitudinal direction are opened. A pressure chamber communicates through the second end with an internal portion of the capillary. A driving part changes a volume of the pressure chamber. A control part outputs a first signal driving the driving part so that the volume of the pressure chamber increases and liquid is suctioned from the first end. A suction signal in the first signal drives the driving part so that the volume of the pressure chamber increases from a volume before suction of the liquid by a first increase amount to become a post-suction volume. A brake signal is output following the suction signal and drives the driving part so that the volume of the pressure chamber is reduced from the post-suction volume by an amount which is smaller in absolute value than the first increase amount.

An adapter assembly for receiving a capillary includes a passage, into which the capillary is or can be received. The adapter assembly has an adapter cone which is configured for being received in or on a correspondingly configured counter cone. The adapter cone, at least over a section for bringing the adapter cone into contact with the counter cone, includes an elastic material that is more elastic than the material of the counter cone. The invention further relates to a counterpart for connecting to the adapter, to an apparatus and to a method for automatically exchanging capillaries.

A handheld solids dispenser. The dispenser includes a housing defining an inlet passage and an outlet passage. A delivery mechanism is supported within the housing and is positioned between the inlet passage and the outlet passage. Actuation of the delivery mechanism causes the delivery mechanism to transport a desired amount of solids material from the inlet passage to the outlet passage. The delivery member may be in the form of a plunger slidably positioned within the housing. The delivery mechanism may be in the form of a screw conveyor driven by a drive motor.

The capillary blood pipette tip system of the present invention includes a pipette tip for collecting capillary blood including a sampling unit having a capillary tube having a first diameter so as to sample a capillary blood; a sample storage unit having a first extension end formed from a distal end of the capillary tube of the sampling unit so as to have a larger area than the sampling unit; a sealing unit closely adhered to a distal opening of the sample storage unit and broken by a quantitative syringe introduced from the outside; a shielding wall surrounding the sealing unit to prevent the sample from splashing from the sample storage unit to the outside when the sealing unit is broken by the quantitative syringe; and a handle unit which is held by a user to sample using the sampling unit; an immunoassay cartridge having at least one pipette tip mounting well having a plunger that presses a sample of a sampling unit of the pipette tip from the bottom to the top when the pipette tip is coupled to the top; and a quantitative syringe for quantitatively sampling the capillary blood collected in the upper part thereof by approaching through the upper part of the pipette tip, when the capillary blood from the sampling unit is collected in the upper part by the pressurization of the plunger during the coupling of the pipette tip to the immunoassay cartridge.

Devices and methods for detecting one or more characteristics of cells with patch clamp electrodes, wherein the used patch clamp electrodes are cleaned by application of ultrasonic vibrations.

The present disclosure relates to the field of liquid handling and dispensing systems in combination with additive manufacturing. In particular, it relates to temperature-controlled units, i.e. dispensing heads and source well holders, for receiving, holding and releasing liquid and semi-liquid material, liquid-handling and dispensing systems, apparatuses and methods for applying temperature-sensitive liquids. A temperature-controlled unit (1) comprises at least one Peltier element (3), each Peltier element having opposite first and second surfaces (4a, 4b). The unit (1) further comprises at least one cooling element (5). The at least one Peltier element (3) is arranged to have each respective first surface (4a) facing a reservoir block (2) of the unit (1). The at least one cooling element (5) is thermally connected to the Peltier element (3) and arranged to transfer heat generated by the at least one Peltier element (3) and dissipate the transferred heat away from the at least one Peltier element (3).

A liquid evaluation system can include a cartridge including a channel configured to pull a liquid into the channel by capillary action. The cartridge can include an upper plate and a lower plate located in close proximity to the upper plate. The lower plate includes a deposition region for dispensing liquid. The extent of the deposition region in one or more directions can be defined by a repellant barrier, such as a boundary with a set of areas configured to be repellant to the liquid. An internal facing surface of each plate can include a corresponding region forming the channel. Each of the regions can be configured to have an affinity for the liquid. The close proximity of the plates and the regions having an affinity for the liquid cause the liquid to be pulled into the channel by capillary action.