A syringe-based device includes a housing, a pre-sample reservoir, and an actuator. The housing defines an inner volume between a substantially open proximal end portion and a distal end portion that includes a port couplable to a lumen-defining device. The pre-sample reservoir is fluidically couplable to the port to receive and isolate a first volume of bodily fluid. The actuator is at least partially disposed in the inner volume and has a proximal end portion that includes an engagement portion and a distal end portion that includes a sealing member. The engagement portion is configured to allow a user to selectively move the actuator between a first configuration such that bodily fluid can flow from the port to the pre-sample reservoir, and a second configuration such that bodily fluid can flow from the port to a sample reservoir defined at least in part by the sealing member and the housing.

A multi-channel pipetting assembly includes a linkage member and a plurality of pipetting structures arranged in parallel. Each pipetting structure includes a pipette body, a piston rod, a piston tube, and an elastic element. The pipette body has a plurality of air chambers with different inner diameters, and the air chambers are arranged axially and communicate with each other. The piston rod is fixed to the linkage member. The piston tube is sleeved on the piston rod. The piston rod and the piston tube are located in the pipette body, and are axially and reciprocatingly movable in the pipette body. The piston rod matches the air chamber with the smallest inner diameter, and the piston tube matches the remaining air chambers. The elastic element is telescopically sleeved on the piston rod and corresponds to the piston tube. Therefore, a plurality of volume ranges meeting the accuracy requirements can be provided.

A syringe-based device includes a housing, a pre-sample reservoir, and an actuator. The housing defines an inner volume between a substantially open proximal end portion and a distal end portion that includes a port couplable to a lumen-defining device. The pre-sample reservoir is fluidically couplable to the port to receive and isolate a first volume of bodily fluid. The actuator is at least partially disposed in the inner volume and has a proximal end portion that includes an engagement portion and a distal end portion that includes a sealing member. The engagement portion is configured to allow a user to selectively move the actuator between a first configuration such that bodily fluid can flow from the port to the pre-sample reservoir, and a second configuration such that bodily fluid can flow from the port to a sample reservoir defined at least in part by the sealing member and the housing.

A syringe-based device includes a housing, a pre-sample reservoir, and an actuator. The housing defines an inner volume between a substantially open proximal end portion and a distal end portion that includes a port couplable to a lumen-defining device. The pre-sample reservoir is fluidically couplable to the port to receive and isolate a first volume of bodily fluid. The actuator is at least partially disposed in the inner volume and has a proximal end portion that includes an engagement portion and a distal end portion that includes a sealing member. The engagement portion is configured to allow a user to selectively move the actuator between a first configuration such that bodily fluid can flow from the port to the pre-sample reservoir, and a second configuration such that bodily fluid can flow from the port to a sample reservoir defined at least in part by the sealing member and the housing.

A pipette for sampling an extended range of volumes of liquid includes a fixed pipette body. An operating rod is movable in translation relative to the pipette body, along a longitudinal axis of the pipette. The pipette includes a suction chamber and a set of N concentric pistons, wherein N corresponds to an integer greater than or equal to 2. Each of the pistons contributes to delimiting the suction chamber. A coupling module couples the operating rod with the set of N concentric pistons. The module is configured in such a way as to be able to be brought into N distinct configurations in which it respectively couples the operating rod with 1, 2, . . . , N pistons.

Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.

A pipette holder that includes: (i) a base; (ii) a recess made in the base, which can removably house a well support; (iii) a pipette support comprising a first housing into which can be inserted a pipette equipped with one or more tubular pipette cones that each comprise a tip intended for pipetting liquid, the first housing opening out onto the recess of the base, the pipette support being translationally mobile relative to the base in a direction parallel to an axis of the pipette cones and mobile between a first position in which the tip of each pipette cone is inserted in a well of the well support and at least one second position in which the tip is outside the well; and (iv) a second housing which can removably house a magnetized part.

An apparatus and a system for filtering a liquid sample in a sample well (310) by transferring the liquid out of the sample well (310) through a filter member (320) situated at a bottom part of the sample well (310). The apparatus and the system include a syringe (100), and a seal member (200) arranged around a nozzle (140) of the syringe (100) in such a way that the syringe (100) is adjustable in connection with an upper part of the sample well (310) in a substantially airtight manner. A method for filtering a liquid sample and use of the system for filtering eluted blood are also disclosed.

The present disclosure provides device for use with a pipette, the device comprising a body comprising one or more sample ports, each sample port comprising a cavity, a bottom, a registration feature comprising a tip landing zone and a guiding path for guiding a pipette tip from the tip landing zone to a tip target location. The invention also features a cassette for use in parallel electrophoretic assays, the cassette comprising a lid comprising the device. The present disclosure also provides methods for making same.

The invention relates to a device (32) for the bottom part of a multichannel pipetting system, comprising two sampling-cone-holding end pieces (6) and also two aspiration chambers (36a, 36b) that engage respectively with the two end pieces, the two aspiration chambers (36a, 36b) being concentric.