The present disclosure relates to a consumable sample partition device and it assembly and use. The sample partition device can be used to test a sample for absence of microorganisms (sterility) and/or for concentration of said organisms (bio-burden). The sample partition device partitions the sample input volume into multiple discrete measurement zones with little or no loss of sample (e.g., zero-loss) and with little operator involvement, thereby reducing operator- and environment-based false positives.

Multiwell devices and methods of filtration using the multiwell devices are disclosed.

An integrated nucleic acid processing apparatus includes a first operation area, a second operation area and a separation wall. The first operation area includes multiple carrying boards for placing objects and reagents for processing nucleic acids in samples, and multiple operation modules for performing operations of nucleic acid processing. The second operation area includes two extraction regions for respectively performing nucleic acid extractions. The separation wall separates the first operation area from the second operation area and includes two openable door sheets spatially corresponding to the two extraction regions. Nucleic acid extraction plates can be moved from the first operation area to the second operation area by means of the carrying boards as the two openable door sheets are opened, and be isolated in the second operation area for performing nucleic acid extractions as the two openable door sheets are closed.

A cap assembly includes a base cap, a chemical resistant sheet, and a closure assembly. The closure assembly is configured for carrying the chemical resistant sheet. The closure assembly is mounted in the base cap. The base cap and the closure assembly together define a central cap assembly aperture therethrough.

This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.

According to one embodiment of the present invention, a tube opening and closing device capable of opening and closing a lid of a tube and comprising a container, a lid coupled to the container so as to enable the container to be blocked, and a joint part for connecting the container and a first side of the lid comprises: a tube supporting rack having a plurality of openings formed on one surface thereof, wherein the containers of the tubes can be inserted into each of the plurality of openings; an opening and closing part positioned at an upper part of the tube supporting rack, rotating around a first rotary shaft and having a coupling groove in which a second side of the lid, which faces the first side of the tube, can be accommodated; and a driving part for rotating the opening and closing part, wherein the lid can be opened and closed with respect to the container through the rotation of the opening and closing part.

The invention relates to a method and a device for optically exciting a plurality of analytes (12) in an array of reaction vessels (14) and for sensing fluorescent light from the analytes (12), wherein excitation light from an excitation light source (38) is supplied to the analytes (12) and wherein fluorescent light from the analytes (12) is simultaneously supplied to a fluorescent detector (34), wherein a plurality of beams (30) of the excitation light is directed into the reaction vessels (14) below the cover (28) through an array of holes (26) in a cover (28) arranged above the array of reaction vessels (14) and a plurality of beams (32) of the fluorescent light from the reaction vessels (14) reaches the fluorescent detector (34). According to the invention it is suggested that the main beams (76) of the plurality of beams (30) of the excitation light diverge within and below the holes (26) into the reaction vessels (14) and/or that the main beams (78) of the plurality of beams (32) of the fluorescent light converge within and above the holes (26) toward the fluorescent detector (34).

A system for biological assay includes a first plate having a plurality of protrusions, a second plate configured for mating with said first plate, the second plate including a plurality of receptacles, each receptacle being configured to receive at least a portion of a corresponding one of said protrusions upon mating of the first plate with the second plate, wherein each protrusion includes a gate electrode configured for facing the respective receptacle upon mating of the first plate with the second plate, and wherein each receptacle further includes at least one source-drain channel operatively associated to a gate electrode carried by a respective protrusion upon mating of the first plate with the second plate.

Provided is a multi-well-based rapid cell culture test device designed such that fluid films with a uniform thickness are formed. The rapid cell culture test device has an array structure of a plurality of aligned well units, each of which includes a first sub-well in which a first fluid is accommodated and a barrier structure surrounding the first sub-well to define the area of the first sub-well. A capillary channel recessed from the bottom surface of the first sub-well while traversing the bottom surface is formed to accommodate the first fluid and the barrier structure is divided into a barrier portion A located adjacent to one end of the capillary channel and a barrier portion B located adjacent to the other end of the capillary channel. The barrier portion A is greater in height than the barrier portion B such that when the barrier portion A is wetted with the first fluid introduced into the first sub-well along its inner wall, a change in the level of the first fluid at the other end of the capillary channel depending on the amount of the first fluid dispensed is minimized.

A heat sealing product suitable for sealing one or more individual containers, said heat sealing product comprising: (i) a plurality of individual heat seals set out in a configuration substantially corresponding to the shape and configuration of the container(s) to be sealed, the size and shape of the individual heat seals corresponding substantially to the size and shape of the tops of the individual container(s) to be sealed; (ii) a peelable support film layer coated on one side with a low tack adhesive, the low tack adhesive serving to hold the individual heat seals in place on the support film layer in the desired configuration prior to the sealing process; (iii) alignment points in the sealing product adapted to enable the heat sealing product and therefore the individual heat seals of the heat sealing product to be aligned substantially exactly with respect to the individual containers to be sealed.