A vacuum manifold for filtration microscopy includes a manifold top having multiple openings, and a capture membrane positioned above and spaced apart from the manifold top, where the capture membrane is configured to deflect into contact with a surface of the manifold top when a negative pressure is applied to the multiple openings. A method for filtration microscopy includes the steps of providing a vacuum manifold including a manifold top having a plurality of openings, and a capture membrane positioned above and spaced apart from the manifold top; applying sample drops to sample spots on the membrane, the sample spots positioned above the plurality of openings; applying a negative pressure to the openings such that the capture membrane contacts a surface of the manifold top; and optically imaging particulates on the capture membrane.

Disclosed here are kits comprising pre-packed stabilizing solutions for stabilizing combinations of biomarkers at room temperature. Such kits can be better adapted for sample collection at a subject's dwelling, thus easing the burdensome requirement of sample collection.

Disclosed herein are devices, apparatus, systems, methods and kits for collecting and storing a fluid sample from a subject. A device for collecting the fluid sample can include a housing comprising a recess having an opening, a vacuum chamber in the housing and in fluidic communication with the recess, and one or more piercing elements that are extendable through the opening to penetrate skin of the subject. The vacuum chamber can be configured for having a vacuum that draws the skin into the recess. The recess can be configured having a size or shape that enables an increased volume of the fluid sample to be accumulated in the skin drawn into the recess.

Provided are valveless microfluidic flowchips comprising fluid flow barrier structures or configurations. Further provided are systems and methods having increased fluid transfer control in a valveless microfluidic flowchip. The systems and methods can be used in the present valveless microfluidic flowchips as well as in currently available valveless microfluidic flowchips.

Systems, methods, and apparatus are disclosed for recovering one or more target cells from a fluid sample. A first chamber aligned with a first surface of a removable filter receives the fluid sample. The removable filter defines a plurality of pores configured to retain the one or more target cells on the first surface and/or in the plurality of pores, each pore of the plurality of pores having a first diameter smaller than a diameter of the one or more target cells in the first surface and a second diameter greater than the first diameter in a second surface of the removable filter. A second chamber comprises a hydrophilic microporous wick structure configured to contact the second surface of the removable filter and capillarize any non-target cells and fluid from the fluid sample, drawing them into the second chamber.

An apparatus for patterning biological cells, and a method of patterning and coculturing biological cells using the apparatus. The apparatus includes a fluidic structure having an outlet and a plurality of inlets, the fluidic structure is arranged to facilitate a flow of a plurality of different cells in a cell suspension therethrough, wherein each of the plurality of inlets is arranged to facilitate a loading of the plurality of different cells from a plurality of supplies into the fluidic structure; and a flow controlling device arranged to control the flow of the plurality of different cells through the fluidic structure and/or the loading of the plurality of different cells from the plurality of supplies through the plurality of inlets; wherein the fluidic structure is further arranged to facilitate a simultaneous observation of the plurality of different cells arranged in a predetermined pattern in the fluidic structure.

Disclosed in one aspect is a method for performing a complete blood count (CBC) on a sample of whole blood by metering a predetermined amount of the whole blood and mixing it with a predetermined amount of diluent and stain and transferring a portion thereof to an imaging chamber of fixed dimensions and utilizing an automated microscope with digital camera and cell counting and recognition software to count every white blood cell and red blood corpuscle and platelet in the sample diluent/stain mixture to determine the number of red cells, white cells, and platelets per unit volume, and analyzing the white cells with cell recognition software to classify them.

Provided are devices, systems and methods for evaluation of hemostasis. Also provided are sound focusing assemblies.

This automated analyzer 100 comprises: a sample probe 11a for dispensing a substance to be dispensed into a plurality of reaction vessels 2 for causing a sample to be analyzed to react with a reagent, a measurement unit (light source 4a, spectrophotometer 4, and control device 21) for measuring a reaction liquid produced from the sample and reagent in a reaction vessel 2, a cleaning tank for probe cleaning, and a control device 21 for controlling the operation of the probe, measurement unit, and cleaning tank 13. The cleaning tank 13 comprise a cleaning pool 36 for storing cleaning water for immersing and cleaning the probe and a drying tank 37 for sucking up the cleaning water on the surface of the probe after the probe has been immersed in the cleaning water of the cleaning water pool 36 and cleaned. As a result, it is possible to reduce the amount of cleaning water used to clean the probe.

The liquid suction tool, liquid supply unit and automated analyzer can reduce an amount of the liquid remaining in the suction conduit while maintaining the strength of the suction conduit. The liquid suction tool 12 has a rod-like suction conduit 31 and a connecting member 32. The suction conduit 31 is inserted into the storage bag 21. A groove 34 is formed on a side surface of the suction conduit 31 to pass the liquid.