The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Described herein are methods for purification of biological material using high gradient magnetic separation. For example, a method includes: providing a ferromagnetic matrix surrounded by a separation column, the separation column including an elongate body defining a lumen having an inlet and an outlet; applying an external magnetic field to the separation column; saturating unspecific binding sites in the ferromagnetic matrix by applying a buffer solution to the ferromagnetic matrix; and introducing biological material into the lumen of the separation column. In some embodiments, the ferromagnetic matrix is uncoated, and the buffer solution includes at least one macromolecule. In some embodiments, the method further includes incubating the ferromagnetic matrix with the buffer solution for at least three minutes to equilibrate the ferromagnetic matrix.

Described herein are methods for purification of biological material using high gradient magnetic separation. For example, a method includes: providing a ferromagnetic matrix surrounded by a separation column, the separation column including an elongate body defining a lumen having an inlet and an outlet; applying an external magnetic field to the separation column; saturating unspecific binding sites in the ferromagnetic matrix by applying a buffer solution to the ferromagnetic matrix; and introducing biological material into the lumen of the separation column. In some embodiments, the ferromagnetic matrix is uncoated, and the buffer solution includes at least one macromolecule. In some embodiments, the method further includes incubating the ferromagnetic matrix with the buffer solution for at least three minutes to equilibrate the ferromagnetic matrix.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Disclosed herein are methods and systems for recovery of ancylite, a rare earth mineral comprising strontium carbonate, from rare earth ore. In many embodiments, the disclosed methods and systems provide for recovery of greater than 50% of the ancylite from an ancylite containing ore. In many embodiments, the ore is subjected to flotation in the presence of an acid, for example a hydroxamic acid, such as octanohydroxamic acid. The ore may also be subjected to magnetic separation, for example wet high intensity magnetic separation.

Disclosed herein are methods and systems for recovery of ancylite, a rare earth mineral comprising strontium carbonate, from rare earth ore. In many embodiments, the disclosed methods and systems provide for recovery of greater than 50% of the ancylite from an ancylite containing ore. In many embodiments, the ore is subjected to flotation in the presence of an acid, for example a hydroxamic acid, such as octanohydroxamic acid. The ore may also be subjected to magnetic separation, for example wet high intensity magnetic separation.

A system for removing iron ore particles adhered by magnetic hysteresis to a magnetic matrix of a vertical magnetic separator, the vertical magnetic separator having a separation ring with a magnetic matrix; an ore feed inlet an ore accumulation vessel positioned in the lower portion of the magnetic matrix and having an outlet for low magnetic-susceptibility material; a magnetic field-generating device adapted to generate a magnetic field in the region of the accumulation vessel; at least one collection tray positioned internally to the magnetic matrix and adapted to collect material with greater magnetic susceptibility detached from the magnetic matrix; and a collecting container adapted to receive the material with greater magnetic susceptibility from at least one collecting tray. The system further includes a demagnetizer; a mechanical device for cleaning the magnetic matrix positioned at a position subsequent to the demagnetizer; and at least one device generating jets of compressed air.

A system for removing iron ore particles adhered by magnetic hysteresis to a magnetic matrix of a vertical magnetic separator, the vertical magnetic separator having a separation ring with a magnetic matrix; an ore feed inlet an ore accumulation vessel positioned in the lower portion of the magnetic matrix and having an outlet for low magnetic-susceptibility material; a magnetic field-generating device adapted to generate a magnetic field in the region of the accumulation vessel; at least one collection tray positioned internally to the magnetic matrix and adapted to collect material with greater magnetic susceptibility detached from the magnetic matrix; and a collecting container adapted to receive the material with greater magnetic susceptibility from at least one collecting tray. The system further includes a demagnetizer; a mechanical device for cleaning the magnetic matrix positioned at a position subsequent to the demagnetizer; and at least one device generating jets of compressed air.

The invention relates to a magnetic matrix for high intensity magnetic separator which is fed with a pulp containing magnetic and non-magnetic particles, the magnetic matrix (8) comprising a series of grooved metal plates (7) on both sides thereof, the grooved plates being arranged in rows parallel to and spaced apart from each other from the same spacing (6) within a housing, each face of each metal grooved plate (7) having the ridges aligned with the valleys of the face facing it of the grooved plate (7), and a corrugated expanded sheet (12) is disposed at each spacing (6) between adjacent grooved plates (7), with corrugations of the corrugated expanded sheets (12) accompanying the ridge-valley alignments of the respective grooved plates (7).