A method is provided including coupling magnetic beads to a population of cells in a fluid sample to form magnetically-labeled cells, magnetically separating the magnetically-labeled cells from non-magnetically-labeled cells in the fluid sample, and separating target cells from non-target cells of the magnetically-labeled cells based on a size difference between the magnetically-labeled target cells and the magnetically-labeled non-target cells. A microfluidic device is provided including a fluidic pathway traversing a magnetic isolation region and a size-based isolation region. The magnetic isolation region includes a magnet positioned to separate magnetically-labeled cells from non-magnetically labeled cells in the magnetic isolation region. The size-based isolation region includes a separator configured to separate cells less than a threshold size from cells greater than a threshold size.

The present invention is directed towards an apparatus and methods for a precise, fast and easy to use manipulation of beads. This method is particularly useful to carry out separation between the beads and the remaining supernants present in the fluid, maximizing the collection and purification efficiencies in tips for liquid handling.

A magnet apparatus for generating a high gradient and/or high strength magnetic field, comprises: two permanent magnets (2, 4) located side-by-side with oppositely oriented magnetic field polarities and end surfaces of opposite polarities next to one another, wherein the magnetic anisotropy of the magnets exceeds the magnetic induction of the material of the magnets; and a mask (6) or masks (6) on a first end of each of the adjacent permanent magnets (2, 4), the mask(s) 6 comprising a non-retentive material covering adjacent end surfaces of the two permanent magnets (2, 4) with a gap (8) along a joining line between the two permanent magnets (2, 4) to form a zone of high-gradient magnetic field above the joining line; wherein the mask(s) (6) are embedded within the magnets (2, 4) and/or have a varying thickness and wherein the mask(s) (6) each have a maximum thickness greater than a tenth of the thickness of the respective magnet (2, 4).

A method and apparatus for removing magnetic beads together with molecular targets of interest from a fluid is described. A consumable bead collection probe is placed in a vessel containing magnetic beads suspended in the fluid. A magnet outside the vessel concentrates magnetic beads on a surface of the collection probe so they may be manipulated in and out of vessels during washing or processing steps without transferring the fluid into or out of a vessel. In a further embodiment, a vibrational source is attached to the collection probe such that, in combination with the magnet in a position external to the vessel, beads may be washed without releasing them from the collection probe.

A filter for treating a fluid in a piping of a heating and/or cooling system, in particular of domestic and/or industrial type, includes: a main body internally having at least one chamber, a first mouth and a second mouth respectively comprising a first duct and a second duct allowing the fluid to enter and/or exit the at least one chamber, wherein the first mouth has a first longitudinal axis and the second mouth has a second longitudinal axis, in particular the second mouth being positioned on the main body in such a way that its second longitudinal axis is substantially perpendicular to the first longitudinal axis of the first mouth; a filtering element for treating the fluid, housed at least partially in the chamber, in particular the filtering element having at least one magnetic element adapted to intercept and trap the ferrous impurities that are present in the fluid to be treated.

A process. The process includes forming a slurry comprising electrode active material particles of one or more lithium-ion electrochemical cells, magnetizing the electrode active material particles and separating the magnetized electrode active material particles from the slurry.

A magnetic assembly for use in a device for conducting assays is disclosed. The magnetic assembly comprises a pole piece having a longitudinal shaft interposed between at least two magnetic elements, each of the at least two magnetic elements having a north magnetic pole and a south magnetic pole; the at least two magnetic elements being orientated such that each north magnetic pole or each south magnetic pole is aligned inwardly towards the shaft; and wherein the pole piece comprises a cap at one end of the shaft which extends at least partially over a lateral surface of each of the at least two magnetic elements. Also disclosed is a device for conducting assays and a method of operating the device.

A pipeline strainer having a body with a straining element therein. One or more magnets are removably inserted into the straining element and configured to be removed from the body without causing liquid within the cavity to drain from the pipeline strainer. A drywell is used to house the magnets. The movement of withdrawing the magnets pulls metal particles along the outer surface of the drywell toward a debris drain. A baffle is disposed at the end of the drywell that is adjacent or near the debris drain to reduce turbulence from the fluid flow within the pipeline strainer.

The present invention concern a method and a device for the isolation of non-magnetic cells from a heterogeneous sample solution containing biological material including desired and undesired cells. The method comprises the steps of: —adding magnetic or magnetizable particles to the sample, wherein said particles have sizes in a range from 100 nm to 4 μm and exhibit surface components which support specific association with target cells, wherein said target cells comprise are either said desired or said undesired cells; —decreasing said external magnetic field gradient; —incubating said sample solution with said magnetic particles to obtain a magnetized cell fraction; —washing said magnetized cell fraction using a washing solution to reduce non-specific binding; —increasing said external magnetic field gradient; —separating said magnetized cell fractionation of target cells from said sample; wherein said sample solution is subjected to an external magnetic field gradient throughout said adding, incubating, washing and separating steps, and wherein said sample solution is rotated at least during said adding, incubating and washing steps.

A system for reducing dust emissions resulting from tire abrasion, comprising a collecting unit (1), arranged at a distance from the tread (4) of a tire (5) and has at least one first electromagnet and/or permanent magnet (2). At least the material with which the tread (4) of the tire (5) is formed is magnetic or is ferromagnetically, ferrimagnetically or anti-ferromagnetically magnetisable, so that the tire abrasion particles (6) created as a result of abrasion of the tread (4) are magnetic or are ferromagnetically, ferrimagnetically or anti-ferromagnetically magnetisable. The at least one first electromagnet and/or permanent magnet (2) is designed to magnetise tire abrasion particles (6) and to accumulate the magnetized tire abrasion particles (6) detached from the material of the tread (4) in a collection point (3), arranged on a vehicle.