Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm.sup.3 and about 0.15 g/cm.sup.3, and/or a specific surface area (SSA) of at least 18 m.sup.2/g, 20 m.sup.2m/g, 25 m.sup.2/g, 30 m.sup.2/g, 32 m.sup.2/g, 34 m.sup.2/g, or 35 m.sup.2/g. Methods for making and using such compositions are also provided.

A fluid atomizer is provided, and the fluid atomizer is used to atomize the fluid into a spray of droplets, and transform the fluid into spray dispersion in the form of intertwined inner conical film and outer conical film layer by atomizing the fluid. The fluid atomizer includes a plurality of inlet channels, at least one swirl chamber, at least one contracting channel, at least one flow passage channel, at least one internal outlet channel, at least one external outlet channel, and at least one channel holder.