The present disclosure relates to an ultrasonic device for real-time and nondestructive assessment of extracellular matrix stiffness, and the method of making and using the novel ultrasonic device.

There are provided an ultrasonic transducer and methods for designing and manufacturing the same. The ultrasonic transducer includes a piezoelectric composite layer configured to be in acoustic communication with a sample and having at least partially decoupled acoustic impedance and electrical impedance properties. The piezoelectric composite layer includes an array of spaced-apart piezoelectric regions, each being made from a piezoelectric material, a filler material positioned between adjacent spaced-apart piezoelectric regions, the filler material comprising a polymer matrix and a non-piezoelectric material in contact with the polymer matrix. In some embodiments, the ultrasonic transducer includes an electrically insulating non-piezoelectric composite layer extending over the piezoelectric composite layer for electrically insulating the piezoelectric composite layer from the sample, the electrically insulating non-piezoelectric composite layer being acoustically matched to the piezoelectric composite layer and the sample.

A cooling system and method for using the cooling system are described. The cooling system includes a plurality of individual piezoelectric cooling elements spatially arranged in an array extending in at least two dimensions, a communications interface and driving circuitry. The communications interface is associated with the individual piezoelectric cooling elements such that selected individual piezoelectric cooling elements within the array can be activated based at least in part on heat energy generated in the vicinity of the selected individual piezoelectric cooling elements. The driving circuitry is associated with the individual piezoelectric cooling elements and is configured to drive the selected individual piezoelectric cooling elements.

Various methods and systems are provided for a multi-frequency transducer array. In one example, the transducer array is fabricated by forming an interdigitated structure from a first comb structure with a first sub-element and a second comb structure with a second sub-element. The interdigitated structure is coupled to a base package, a matching layer, and a backing layer to form a plurality of multi-frequency transducers.

A method of fabricating and controlling a thick-film transducer array for steering and focusing ultrasonic waves within a substrate volume is provided. A ceramic film composition can be coated on a substrate volume in one or more layers. The ceramic film can be masked with a plastic sheet out of which an electrode pattern is cut. Conductive electrode material can be applied to the pattern to create a transducer array that can be polarized with an applied electric field. A method of controlling a thick-film transducer array comprises exciting one or more array elements to generate a wavefield in a substrate volume, the wavefield can be reflected by features within the substrate volume, one or more array elements can receive reflected wavefield signals, and images of the insonified substrate volume can be generated.

An ultrasound sensor includes a frame, wherein the frame includes an outer perimeter, an inner perimeter, and a midsection, wherein the midsection extends across the inner perimeter. The sensor further includes two or more transducer elements, wherein the two or more transducer elements are located within the inner perimeter, and include one or more membranes that include a bottom portion that includes a first piezoelectric layer and second piezoelectric layer, wherein the two or more transducer elements are each separated from the midsection, wherein the two or more transducer elements are configured to each activate a transmit mode and receive mode, wherein the transmit mode is configured to transmit a signal and the receive mode is configured to receive a signal, wherein a first transducer element activates the transmit mode when a second transducer element does not activate the transmit mode.

An ultrasonic oscillator unit including an ultrasonic oscillator array in which a plurality of ultrasonic oscillators are arranged; an electrode part having a plurality of electrodes electrically connected to the plurality of ultrasonic oscillators, respectively; a circular-arc backing material layer disposed on a rear surface of the ultrasonic oscillator array; three or more wiring boards electrically connected to the plurality of electrodes of the electrode part; and three or more connectors to which a plurality of cables are connected, respectively. The three or more wiring boards are respectively mounted to the three or more connectors and electrically connect the plurality of electrodes of the electrode part to the plurality of cables. The three or more connectors are arranged on a rear surface side of the backing material layer in a width direction.

In one embodiment, a transducer comprises a first piezoelectric stack comprising a piezoelectric material; a first layer in contact with the piezoelectric stack; and a base structure beneath the first layer. The first layer has a first displacement between a first portion of the base structure and the first layer, and the first displacement is configurable by a first bias voltage received by the transducer.

An ultrasound transducer, wherein the ultrasound transducer includes a membrane including a top portion and a bottom portion, wherein the membrane is configured to vibrate and generate an ultrasound in response to voltage applied the transducer, wherein the membrane includes a perimeter including a plurality of sides and a top surface and a bottom surface with one or more feet extending away from the bottom surface; and a support member that attaches to and connects to the membrane and supports the membrane, wherein the support member includes one or more platforms extending to and attaching to the membrane and a substrate, wherein a first end of the platform connects to the membrane and includes a support portion, wherein the support portion away from the platform, wherein the platform includes the one or more piezoelectric layers, wherein the one or more platforms support and surround the membrane.

Multifunctional ultrasound systems and methods for body section registration and mapping of microbubble dynamics. A system is provided that includes one or more micromachined ultrasonic transducer arrays (MUTAs) configured to capture a high-resolution image of at least a portion of a body section using ultrasound and monitor microbubble activity during ultrasound treatment. The system includes an image registration module configured to spatially register the high-resolution image with a reference image. The system includes electronics configured to control one or more of drive signal amplitude, frequency filtering, multiplexing, and DC bias voltage. The system can be configured to control ultrasound treatment based on the monitoring of the microbubble activity during treatment.