Recently, we have introduced 3D-micro-patterned pharmaceutical dosage forms for enhancing the efficacy, safety, convenience, and cost-effectiveness of drug therapies. Presented herein is an apparatus for the manufacture of such dosage forms. The apparatus comprises at least a first extruder and at least a second extruder. The first extruder comprises an extruder channel having an exit port with a valve mated to an input port of a second extruder. Said second extruder comprises a translatable piston for extruding plasticized fiber at controlled speed. The apparatus further comprises a stage movable at the controlled speed of the extruded fiber for depositing said fiber to a three dimensional structural framework.

An encapsulant compound apparatus, includes a mechanical operator, and an insert disposed on a surface of the mechanical operator. The insert operates to capture foreign material in the encapsulant compound.

Provided is a die lip opening/closing device capable of preventing wear and damage on an actuator of a pusher. According to the present invention, there is provided a die lip opening/closing device, the device including an opening/closing structure configured to open and close a die lip of a T-die in response to a linear motion of a pusher, and an actuator configured to actuate the pusher to move linearly, wherein the pusher includes a plurality of sub-pushers disposed along a longitudinal direction of the die lip, and the actuator is provided for each of the sub-pushers.