Systems and methods for improving tire uniformity include identifying at least one candidate process harmonic and corresponding period. A set of uniformity waveforms is then collected for each test tire in a set of one or more test tires. To provide better data for analysis, the collection of waveforms may include multiple waveforms including measurements obtained before and/or after cure, in clockwise and/or counterclockwise rotational directions, and while the tire is loaded and/or unloaded. The uniformity waveforms may be re-indexed to the physical order of the at least one candidate process harmonic, and selected data points within the waveforms may optionally be deleted around a joint effect or other non-sinusoidal effect. The re-indexed, optionally partial, waveforms may then be analyzed to determine magnitude and azimuth estimates for the candidate process harmonics. Aspects of tire manufacture may then be modified in a variety of different ways to account for the estimated process harmonics.