Production systems for producing a radioactive drug product include a hot cell having a radiation isolating shielding and a dispensing unit positioned within the hot cell. The dispensing unit includes a manipulator arm for manipulating a closure component of a vial. The system further includes a pneumatic line extending from the manipulator arm and through the radiation isolating shielding to a location outside of the hot cell and a pressure sensor connected to the pneumatic line and positioned outside of the radiation isolating shielding. The pressure sensor is operable to detect air pressure within the pneumatic line.

A plant (1) for filling and closing cans (2) under hygienic conditions which comprises a hygienic compartment (3), a lid applying device (7) and an inlet (30) for a filling material. The lid applying device (7) is arranged in the hygienic compartment (3) and the inlet (30) is formed on the hygienic compartment (3). When used as intended, one or more cans (2) can be assigned to the hygienic compartment (3) and the hygienic compartment (3) can be moved together with the can(s) (2) in the system (1).

A method of closing an open end of a receptacle having a wall with an inner wall surface. The method includes providing an end element including an internal portion thereof formed for at least partial engagement thereof with the wall. One or more heating elements are provided, for heating a heated layer of the internal portion to a hot working temperature in an inert atmosphere. When the heated layer is at the hot working temperature, an engagement part of the heated layer is engaged with a preselected part of the wall. One or both of the receptacle and the end element are subjected to an engagement motion relative to the other while the engagement part and the preselected part are engaged for plastic deformation thereof, to at least partially bond the heated layer and the wall of the receptacle together to form a gastight container assembly.

A system for assembling a container and closure comprising an expanding collet which has a plurality of pivoting collet segments, each configured to simultaneously pivot radially outward about a pivot point. The collet comprises a lip that is engageable with the rim of the open end of the container and an angled tip positioned radially inward from the lip and shaped to press a countersink portion of the closure against an interior wall of the container as the collet segments pivot radially outward. As the container and the chuck are brought together, the rim engages with the lips of the collet segments and causes the angled tips of the collet segments to pivot outward toward the interior wall of the container, thereby pushing the countersink portion of the closure against the interior wall of the container.

A method of closing an open end of a receptacle having a wall with an inner wall surface. The method includes providing an end element including an internal portion thereof formed for at least partial engagement thereof with the wall. One or more heating elements are provided, for heating a heated layer of the internal portion to a hot working temperature in an inert atmosphere. When the heated layer is at the hot working temperature, an engagement part of the heated layer is engaged with a preselected part of the wall. One or both of the receptacle and the end element are subjected to an engagement motion relative to the other while the engagement part and the preselected part are engaged for plastic deformation thereof, to at least partially bond the heated layer and the wall of the receptacle together to form a gastight container assembly.