A chew resistant dog toy securely contains and retains a replaceable lickable treat. The toy facilitates the predictable, gradual, and prolonged ingestion of the treat by an animal's licking of an available surface of the lickable treat. The dog toy has a chew resistant body (typically made of a tough polymer or a hard rubber material) and a channel having an elongated opening along a major surface of the toy. The channel is adapted to receive and securely hold and retain the treat. The treat may or may not contain one or more active ingredients that are useful for promoting a calming effect on the dog, including active agents (such as theanine, Relora, SAMe, GABA, ashwagandha, tryptophan, turmeric, Boswellia serrata, panax ginseng, Methylsulfonylmethane, 5-HTP, etc.), other botanicals that facilitate sleep and relaxation (such as Valerian root, Chamomile, Lemon balm, Passion flower, Kavakava, Tulsi-Holy basil (Ocimum tenuiflorum)) and cannabinoids (such as CBD, CBN, etc.).

Mycotoxin-deactivating aptamers, especially DNA aptamers, bind to mycotoxins in feed and feed ingredients resulting in the reduction or elimination of toxic and carcinogenic effects of mycotoxins. The invention also discloses a composition comprising a mycotoxin-deactivating aptamer, a binding agent, a biotransforming agent and an antioxidant for detoxifying mycotoxins in feeds. In addition, the invention teaches the methods of preparing the mycotoxin-deactivating aptamer-based composition and also the methods of using it as a feed additive. Furthermore, the invention relates to the use of the mycotoxin-deactivator/s alone, or in a composition comprising the aptamers and other mycotoxin-detoxifying agents, in feeds and feed ingredients for detoxifying the major mycotoxins such as aflatoxins, deoxynivalenol, zearalenone, fumonisins and ochratoxin A.

Mycotoxin-deactivating aptamers, especially DNA aptamers, bind to mycotoxins in feed and feed ingredients resulting in the reduction or elimination of toxic and carcinogenic effects of mycotoxins. The invention also discloses a composition comprising a mycotoxin-deactivating aptamer, a binding agent, a biotransforming agent and an antioxidant for detoxifying mycotoxins in feeds. In addition, the invention teaches the methods of preparing the mycotoxin-deactivating aptamer-based composition and also the methods of using it as a feed additive. Furthermore, the invention relates to the use of the mycotoxin-deactivator/s alone, or in a composition comprising the aptamers and other mycotoxin-detoxifying agents, in feeds and feed ingredients for detoxifying the major mycotoxins such as aflatoxins, deoxynivalenol, zearalenone, fumonisins and ochratoxin A.

A traditional Chinese medicine polysaccharide extract freeze-drying protective agent, a direct-to-vat starter and preparation methods thereof are disclosed, which belong to the technical field of feed starter. The compound traditional Chinese medicine polysaccharide extract freeze-drying protective agent includes Poria cocos polysaccharide extract, Atractylodes macrocephala polysaccharide extract, Radix codonopsis polysaccharide extract, L-tyrosine, α-cyclodextrin and polyethyleneimine. Its application in the freeze-drying protection of direct-to-vat starter of aquatic fermentation feed can reduce the damage to the cells caused by freeze-drying, improve the survival rate of the cells in the starter after freeze-drying, effectively prolong the storage period of the starter, and ensure that the fermentation activity remains at a high level during storage.

A traditional Chinese medicine polysaccharide extract freeze-drying protective agent, a direct-to-vat starter and preparation methods thereof are disclosed, which belong to the technical field of feed starter. The compound traditional Chinese medicine polysaccharide extract freeze-drying protective agent includes Poria cocos polysaccharide extract, Atractylodes macrocephala polysaccharide extract, Radix codonopsis polysaccharide extract, L-tyrosine, α-cyclodextrin and polyethyleneimine. Its application in the freeze-drying protection of direct-to-vat starter of aquatic fermentation feed can reduce the damage to the cells caused by freeze-drying, improve the survival rate of the cells in the starter after freeze-drying, effectively prolong the storage period of the starter, and ensure that the fermentation activity remains at a high level during storage.

The invention relates to a method for producing, amongst other things, amino-acid and/or hydroxycarboxylic-acid metal chelates, a solvent-free mixture of at least one metal oxide, metal hydroxide, metal carbonate or oxalate, and the solid organic acid is subjected to intensive mechanical stress. According to the invention, this is done in that the reaction partners are introduced in particle form into a fluid stream of a fluid-bed countercurrent mill operating without grinding elements, wherein mechanical activation of at least one of the reaction partners is effected by collision processes within a reaction chamber formed in a region of the fluid stream, and a solid body reaction to form the metal chelate is triggered. The novel method operates very energy-efficiently and with a high specific yield. It leads to a product having compact particles in the small, single-digit micrometer range having a comparatively narrow particle sizc distribution and a large surface. The product is homogenous and very pure. Thermal loading or decomposition of the organic chelate ligands, in particular of the amino acids, is likewise avoided, as are contaminants from milling and grinding element abrasion.

The invention relates to a method for producing, amongst other things, amino-acid and/or hydroxycarboxylic-acid metal chelates, a solvent-free mixture of at least one metal oxide, metal hydroxide, metal carbonate or oxalate, and the solid organic acid is subjected to intensive mechanical stress. According to the invention, this is done in that the reaction partners are introduced in particle form into a fluid stream of a fluid-bed countercurrent mill operating without grinding elements, wherein mechanical activation of at least one of the reaction partners is effected by collision processes within a reaction chamber formed in a region of the fluid stream, and a solid body reaction to form the metal chelate is triggered. The novel method operates very energy-efficiently and with a high specific yield. It leads to a product having compact particles in the small, single-digit micrometer range having a comparatively narrow particle sizc distribution and a large surface. The product is homogenous and very pure. Thermal loading or decomposition of the organic chelate ligands, in particular of the amino acids, is likewise avoided, as are contaminants from milling and grinding element abrasion.

Disclosed provides a compound nutrient capable of repairing damaged intestinal tract of piglets and application thereof. The compound nutrient comprises the following components in weight percentage: organic acid 30-50%, amino acid 20-30%, enzyme preparation 8-15%, Bacillus subtilis 5-15%, mineral element 4-6%, glucose 5-20%. The enzyme preparation includes amylase, lipase and protease, and the weight ratio of amylase, lipase and protease is 1-2:1:1-2. The compound nutrient can repair the intestinal health of piglets with diarrhea, reduce the rate of diarrhea, and improve the growth performance.

Disclosed provides a compound nutrient capable of repairing damaged intestinal tract of piglets and application thereof. The compound nutrient comprises the following components in weight percentage: organic acid 30-50%, amino acid 20-30%, enzyme preparation 8-15%, Bacillus subtilis 5-15%, mineral element 4-6%, glucose 5-20%. The enzyme preparation includes amylase, lipase and protease, and the weight ratio of amylase, lipase and protease is 1-2:1:1-2. The compound nutrient can repair the intestinal health of piglets with diarrhea, reduce the rate of diarrhea, and improve the growth performance.

The present disclosure provides a feed additive for domesticated animals that is capable of stimulating muscle function and health, as well as associated methods for promoting muscle function and health and zootechnical performance in domesticated animals. The animal feed additive provided contains Ribes alpinum, or an extract thereof. The present disclosure also describes methods for improving muscle function and health via the dietary inclusion of Ribes alpinum, or an extract thereof.