A chew resistant dog toy securely contains and retains a replaceable lickable treat. The toy facilitates the predictable, gradual, and prolonged ingestion of the treat by an animal's licking of an available surface of the lickable treat. The dog toy has a chew resistant body (typically made of a tough polymer or a hard rubber material) and a channel having an elongated opening along a major surface of the toy. The channel is adapted to receive and securely hold and retain the treat. The treat may or may not contain one or more active ingredients that are useful for promoting a calming effect on the dog, including active agents (such as theanine, Relora, SAMe, GABA, ashwagandha, tryptophan, turmeric, Boswellia serrata, panax ginseng, Methylsulfonylmethane, 5-HTP, etc.), other botanicals that facilitate sleep and relaxation (such as Valerian root, Chamomile, Lemon balm, Passion flower, Kavakava, Tulsi-Holy basil (Ocimum tenuiflorum)) and cannabinoids (such as CBD, CBN, etc.).

Methods of detecting the presence of one copy or 2 copies of a minor allele of one or more single nucleotide polymorphisms selected from the group consisting of SNP A3_117040611, SNP A3_117041908 and SNP A3_117081913 are disclosed. Methods of identifying a feline subject as being at an increased likelihood of developing cat kidney disease are disclosed. Methods of monitoring the health of a feline subject identified as having an increased likelihood of developing CKD are provided. Methods of monitoring the health of a feline subject and response to treatment for renal disease that comprise quantifying at 2PY present are provided. Methods of delaying onset and severity of cat kidney disease in a feline subject identified as having an increased likelihood of developing CKD and methods of treating cats that have CKD are provided.

A flavor composition comprising at least one compound that modulates, increases and/or enhances the activity of a GPR120 fatty acid receptor that can be used to enhance the fatty acid taste and/or palatability of pet food products is described herein. Also disclosed herein are methods for identifying said compounds.

A flavor composition comprising at least one compound that modulates, increases and/or enhances the activity of a GPR120 fatty acid receptor that can be used to enhance the fatty acid taste and/or palatability of pet food products is described herein. Also disclosed herein are methods for identifying said compounds.

Long lasting edible pet chews are disclosed. Processes of producing such pet chews are further disclosed.

The invention provides compositions and methods for treatment of epilepsy in an animal. In one embodiment, a method for treating epilepsy in a companion animal can comprise administering to the companion animal a food composition comprising a medium chain triglyceride (MCT), wherein the MCT is present in the food composition in an effective amount for reducing or preventing seizures when the food composition is administered to the companion animal.

A pet food containing naturally occurring copper that can be used as a prophylactic diet to prevent and/or reduce copper storage disease, dilated cardiomyopathy, adverse gastrointestinal food reactions, and/or food allergies in pets is provided. A method for forming this pet food containing naturally occurring copper includes: providing a formula selected from the group consisting of chicken meal, corn gluten, duck, rabbit, venison, fish, peas, potato, barley, rice, corn, and any combinations thereof; and adding one or more ingredients having a naturally occurring copper source to provide a naturally occurring copper concentration in the pet food composition from about 7.3 ppm to about 25.0 ppm, adjusted for a dry matter basis.

A pet food containing naturally occurring copper that can be used as a prophylactic diet to prevent and/or reduce copper storage disease, dilated cardiomyopathy, adverse gastrointestinal food reactions, and/or food allergies in pets is provided. A method for forming this pet food containing naturally occurring copper includes: providing a formula selected from the group consisting of chicken meal, corn gluten, duck, rabbit, venison, fish, peas, potato, barley, rice, corn, and any combinations thereof; and adding one or more ingredients having a naturally occurring copper source to provide a naturally occurring copper concentration in the pet food composition from about 7.3 ppm to about 25.0 ppm, adjusted for a dry matter basis.

Methods of preventing or decreasing PEDv and/or Salmonella bacteria in animal feed, feed ingredients, and pet food are provided. The methods utilize generally safe chemical mitigants, such as medium chain fatty acids, essential oils, and sodium bisulfate. The chemical mitigants are introduced to the feed or feed ingredients at inclusion rates selected so as to prevent or decrease PEDv and/or Salmonella bacteria in the animal feed, feed ingredients, or pet food. The methods are particularly suitable for use in post-processing treatment of animal feed, feed ingredients, or pet food that will be transported and stored for multiple days or weeks.

Methods of preventing or decreasing PEDv and/or Salmonella bacteria in animal feed, feed ingredients, and pet food are provided. The methods utilize generally safe chemical mitigants, such as medium chain fatty acids, essential oils, and sodium bisulfate. The chemical mitigants are introduced to the feed or feed ingredients at inclusion rates selected so as to prevent or decrease PEDv and/or Salmonella bacteria in the animal feed, feed ingredients, or pet food. The methods are particularly suitable for use in post-processing treatment of animal feed, feed ingredients, or pet food that will be transported and stored for multiple days or weeks.